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What is the body's normal response to tissue damage from any source (may occur in any tissue or organ)?
- Inflammation
- (It is an attempt by the body to remove the damaging agent and repair the damaged tissue.)
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What are the Clinical Presentations (s/s) of Inflammation?
heat, edema (swelling), redness, and pain.
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What enzymes are required for prostiglandin production?
Cyclooxygenase (Cox enzymes)
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What are the 2 Forms of the Enzyme Cyclooxygenase?
& Where are they present?
- Cox-1 @ all tissues
- Cox-2 @ sites of injury
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What do the Cox enzymes promote?
Inflamation, pain, and fever
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What does the Cox-1 enzyme do?
Cox-1 supports platelets and protects the stomach
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What is the function of the Cox-2 enzyme?
Cox-2 promotes inflammation, synthesizes pain receptors, and mediates fever in the brain
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What medications block the Cox enzymes?
- NSAIDS (Non-Steriodal Anti-Inflammatory Drugs)
- Thus they block/reduce inflamation, pain, and fever
- & they can cause stomach ulcers b/c they lower prosteglandins
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The Cox-1 enzyme reduces _______ and promotes ________ & ________
Gastric acid secretion, Renal Blood Flow & platelet agrivation (clotting)
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What could happen if you inhibit the Cox-1 enzyme?
- Increased Bleeding
- Increased Gastric upset
- Decreased Renal function & clots
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What could happen if you inhibit Cox-2 enzymes?
Supress inflammation & theraputic effects of pain meds
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Which drugs Block or alter the chemical reactions associated with the inflammatory response?
Anti-inflammatory Agents
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Name 4 types of Anti-Inflammatory Agents.
- Corticosteroids
- Antihistamines
- Salicylates
- NSAIDS
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Which anti-inflammatory drug is used systemically (all over) to block the inflammatory and immune systems. (they block prostiglandins)
Corticosteroids
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Which anti-inflammatory drugs block the release of histamine in the initiation of the inflammatory response.
Antihistamines
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