What is the body's normal response to tissue damage from any source (may occur in any tissue or organ)?
- (It is an attempt by the body to remove the damaging agent and repair the damaged tissue.)
What are the Clinical Presentations (s/s) of Inflammation?
heat, edema (swelling), redness, and pain.
What enzymes are required for prostiglandin production?
Cyclooxygenase (Cox enzymes)
What are the 2 Forms of the Enzyme Cyclooxygenase?
& Where are they present?
- Cox-1 @ all tissues
- Cox-2 @ sites of injury
What do the Cox enzymes promote?
Inflamation, pain, and fever
What does the Cox-1 enzyme do?
Cox-1 supports platelets and protects the stomach
What is the function of the Cox-2 enzyme?
Cox-2 promotes inflammation, synthesizes pain receptors, and mediates fever in the brain
What medications block the Cox enzymes?
- NSAIDS (Non-Steriodal Anti-Inflammatory Drugs)
- Thus they block/reduce inflamation, pain, and fever
- & they can cause stomach ulcers b/c they lower prosteglandins
The Cox-1 enzyme reduces _______ and promotes ________ & ________
Gastric acid secretion, Renal Blood Flow & platelet agrivation (clotting)
What could happen if you inhibit the Cox-1 enzyme?
- Increased Bleeding
- Increased Gastric upset
- Decreased Renal function & clots
What could happen if you inhibit Cox-2 enzymes?
Supress inflammation & theraputic effects of pain meds
Which drugs Block or alter the chemical reactions associated with the inflammatory response?
Name 4 types of Anti-Inflammatory Agents.
Which anti-inflammatory drug is used systemically (all over) to block the inflammatory and immune systems. (they block prostiglandins)
Which anti-inflammatory drugs block the release of histamine in the initiation of the inflammatory response.