Musculoskeletal Medications

  1. What is the body's normal response to tissue damage from any source (may occur in any tissue or organ)?
    • Inflammation
    • (It is an attempt by the body to remove the damaging agent and repair the damaged tissue.)
  2. What are the Clinical Presentations (s/s) of Inflammation?
    heat, edema (swelling), redness, and pain.
  3. What enzymes are required for prostiglandin production?
    Cyclooxygenase (Cox enzymes)
  4. What are the 2 Forms of the Enzyme Cyclooxygenase?
    & Where are they present?
    • Cox-1 @ all tissues
    • Cox-2 @ sites of injury
  5. What do the Cox enzymes promote?
    Inflamation, pain, and fever
  6. What does the Cox-1 enzyme do?
    Cox-1 supports platelets and protects the stomach
  7. What is the function of the Cox-2 enzyme?
    Cox-2 promotes inflammation, synthesizes pain receptors, and mediates fever in the brain
  8. What medications block the Cox enzymes?
    • NSAIDS (Non-Steriodal Anti-Inflammatory Drugs)
    • Thus they block/reduce inflamation, pain, and fever
    • & they can cause stomach ulcers b/c they lower prosteglandins
  9. The Cox-1 enzyme reduces _______ and promotes ________ & ________
    Gastric acid secretion, Renal Blood Flow & platelet agrivation (clotting)
  10. What could happen if you inhibit the Cox-1 enzyme?
    • Increased Bleeding
    • Increased Gastric upset
    • Decreased Renal function & clots
  11. What could happen if you inhibit Cox-2 enzymes?
    Supress inflammation & theraputic effects of pain meds
  12. Which drugs Block or alter the chemical reactions associated with the inflammatory response?
    Anti-inflammatory Agents
  13. Name 4 types of Anti-Inflammatory Agents.
    • Corticosteroids
    • Antihistamines
    • Salicylates
    • NSAIDS
  14. Which anti-inflammatory drug is used systemically (all over) to block the inflammatory and immune systems. (they block prostiglandins)
  15. Which anti-inflammatory drugs block the release of histamine in the initiation of the inflammatory response.
Card Set
Musculoskeletal Medications
Unit 5