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6 classes of hormonal therapy for CA
- SERMS
- Aromatase Inhibitors
- Progestins and Androgens
- Gonadotropin-Releasing Hormone Analogs
- Antiandrogens
- Somatostatin Analogs
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4 classes of differentiation agents for CA
- Retinoids
- Histone Deacetylase (HDAC) Inhibitors
- DNA Methyltransferase (DNMT) Inhibitors
- Arsenic Trioxide
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4 Classes of angiogenesis inhibitors for CA
- Endogenous inhibitors
- VEGFR inhibitors
- Integrin inhibitors (alphavB3)
- Matrix metalloproteinase inhibitors (MMPI)
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Classes and subclasses of protein processing inhibitors for CA
- Post-Translational ModificationsTyr kinase inhibitors (EGFR, BCR-ABL, VEGF)
- Ser/Thr kinase inhibitors (mTOR)
- Farnesyl transferase inhibitors (FTIs)
- Protein DegradationProteasome inhibitors
- Matrix metalloprotease inhibitors (MMPIs)
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4 Classes of Biotherapeutics for CA
- Enzymes
- Mabs
- Cytokines (interferons, interleukins, hematopoietic growth factors)
- Vaccines
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7 Miscellaneous Classes of Cancer Drugs
- Photosensitizers
- Hydroxyurea
- Amifostine
- Bisphosphonates
- COX Inhibitors
- Pgp Inhibitors
- Unknown mechanism
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Pharmacophore model for HDAC inhibitors
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What element do HDAC inhibitors chelate?
Zinc
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Rate limiting enzyme in estradiol biosynthesis.
Aromatase
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MOA of arsenic trioxide
generates reactive oxygen species leading to cell death
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3 Classes of tyrosine kinase inhibitors
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Integren antagonist (AvB3)
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