What accumulates in adenosine deaminase (ADA) deficiency?
adenosine, which leads to accumulation of dATP (inhibitor off ribonucleotide reductase)
produces general deficienct of dNTPs leading to an ineffective immune system
What is methotrexate a analog to?
folate, competetive inhibitor for dihydrofolate reductase, lack of tetrahydrofolate inhibits thymidylate synthase
What is AZT used to treat and what does it compete with?
HIV, it competes with dTTP inhibiting DNA replication
What does trimethoprim inhibit?
bacterial dihydrofolate reductase, inhibiting bacterial growth
Lecture 47 pyrimidine biosynthesis