MED-Methylprednisolone

Corticosteroid

• Intermediate-acting, synthetic adrenal corticosteroid.
• Decreases inflammation by reversing increased capillary permeability
• Suppresses migration of leukocytes and fibroblasts to the site of injury.
• Stabilizes lysosomes

• Severe asthma
• Anaphylaxis
• COPD

None in anaphylaxis

• Patients with peptic ulcer disease
• CHF
• TB

• HTN
• CHF
• Delayed wound healing
• Hyperglycemia
• Hypokalemia
• Headache
• Peptic ulcer
• Circulatory collapse
• N/V
• CNS depression

Use with caution in pts on salicylates, phenytoin, rifampin, theophylline, furosemide, thiazide diuretics

• Adult: 125-250 mg IVP/IM
• Pedi: 1 mg/kg IVP