What neurotransmitters are these amino acids converted into?
What type of fibers is norepinephrine (NE) the principal neurotransmitter for?
sympathetic postganglionic fibers
What is alpha-methyldopa used to treat?
hypertension (create alpha-methylnorepinephrine a false neurotransmitter)
How are catecholamines released?
What is the function of DAT NET and SERT?
monoamine reuptake of dopamine, norepinephrine, and serotonin (they are all sodium dependent)
What is the function of VMAT-2?
vesicular monoamine transported, especially dopamine, stores returned catecholamines in vesicles (hydrogen ion antiport=catecholamine uptake is accompanied by a H+ exit)
What terminates the activity of norepinephrine?
reuptake by NET
dilution after leaving synaptic cleft
metabolic tranformation (MOA and COMT)
What is the cause of Parkinson disease?
What is the treatment?
Loss of dopaminergic neurons in the substantia nigra and corpus striatum
Replace the missing dopamine (L-Dopa will cross the BBB and restore the missing dopamine)
What is the structural analog of L-dopa that helps to increase L-dopa's effectiveness?
Lecture 44 amino acid and catecholamine synthesis