Lecture 44.txt

What neurotransmitters are these amino acids converted into?
glutamate?
cysteine?
taurine?
serotonin?
tyrosine?
- glutamate-->GABA
- cysteine-->taurine
- tryptophan-->serotonin
- tyrosine-->catecholamines
What type of fibers is norepinephrine (NE) the principal neurotransmitter for?

sympathetic postganglionic fibers
What is alpha-methyldopa used to treat?

hypertension (create alpha-methylnorepinephrine a false neurotransmitter)
How are catecholamines released?

Calcium-mediated exocytosis
What is the function of DAT NET and SERT?

monoamine reuptake of dopamine, norepinephrine, and serotonin (they are all sodium dependent)
What is the function of VMAT-2?

vesicular monoamine transported, especially dopamine, stores returned catecholamines in vesicles (hydrogen ion antiport=catecholamine uptake is accompanied by a H+ exit)
What terminates the activity of norepinephrine?
- reuptake by NET
- dilution after leaving synaptic cleft
- metabolic tranformation (MOA and COMT)
What is the cause of Parkinson disease?
What is the treatment?
- Loss of dopaminergic neurons in the substantia nigra and corpus striatum
- Replace the missing dopamine (L-Dopa will cross the BBB and restore the missing dopamine)
What is the structural analog of L-dopa that helps to increase L-dopa's effectiveness?

Carbidopa

Author

cjharmon311

44441

Card Set

Lecture 44.txt

Description

Lecture 44 amino acid and catecholamine synthesis

Updated

2010-10-24T07:14:36Z

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