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Pharmacology Exam 3
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Sympathetic Activation on HR
increases
Sympathetic Activation on BP
increases
Sympathetic Activation on BG
increases
Sympathetic Activation on pupil diameter
increases
Sympathetic Activation on cardiac contractility
increases
Sympathetic Activation on GI motility
decreases
Sympathetic Activation on Bronchi
dilation
Parasympathetic activation effect on HR
decrease
Parasympathetic activation effect on pupil diameter
decrease
Parasympathetic activation effect on GI motility
increase
Parasympathetic activation effect on bronchi
constriction
Parasympathetic effect on saliva
watery
sympathetic effect on saliva
thick
Metyrosine
inhibits tyrosine hydroxylase
carbidopa
inhibits dopamine production peripherally
reserpine
inhibits VMAT transporter storage of NE into vesicles
Cocaine
inhibits reuptake of NE
TCAs
inhibits reuptake of NE
Amphetamine
increases dopamine concentrations in nerve terminals
selegiline
inhibits MAO, decreasing degredation of catecholamines
Bretylium and guanethidine
inhibit vesicle protiens that help release NE
Patients lacking pseudocholinesterse
have longer effects of succinylcholine
Hemicholinium
inhibits the influx of choline
vesamicol
inhibits the uptake of ACH into vesicles
Botulinium toxin
inhibits SNAPs for vesicle formation
Latrotoxin
venom of black widow spider
stimulates ACH release
Neostigmine
used for myasthenia gravis
Hexamethonium
anti HTN crisis
Depolarizing drugs (ACH)
nicotine
stimulates blockade at high doses
Competitive ACH blockers
trimethaphane
TEA
Mecamylamine (low dose)
Non-competitive blockers
hexamethonium
mecamylamine (high dose)
predominant tone determined by sympathetics
arteries
veins
sweat glands
predominant tone determined by parasympathetics
heart
eye
GI
bladder
salivary glands
effect of ganglionic blockade on arteries and viens
dilation, hypotention
effect of ganglionic blockade on iris
mydriasis
effect of ganglionic blockade on ciliary muscles
cycloplegia
effect of ganglionic blockade on GI tract
constipation
effect of ganglionic blockade on bladder
urinary retention
effect of ganglionic blockade on salivary glands
xerostomia
effect of ganglionic blockade on sweat glands
anhidrosis
decrease peripheral resistance
increase HR
B2 adrinergic drugs
increase peripheral resistance
decrease HR
alpha adrenergic drugs
Author
Rx2013
ID
44284
Card Set
Pharmacology Exam 3
Description
Nervous System
Updated
2010-10-23T02:07:35Z
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