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What is selective toxicity?
- Drugs should have selective toxicity. Drugs that kill the pathogen and not the host.
- Bacteria - target cell wall (peptidoglycan), ribosomes (70s) and enzymes.
- Fungi - target engostreal in the cell membrane.
- viral - use our cells to reproduce making it hard to come up with drugs to fight them. Drugs target cell enzymes.
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What are the classifications of drugs?
- Cidal - kills the pathogen.
- Static - slows down, stops or slows reproduction of pathogen.
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What do bacterial drugs do?
- Stop cell wall synthesis
- cell walls protect from osmotic pressure, made of peptidoglycan.
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What drugs prevent cell wall synthesis?
- β-lactams which bind to enzymes to the crosslinks for peptidoglycans. R- []
- (inhibit the protien cross links between NAM)
- Binds to Penicillin Binding Proteins (PBS are enzymes for cell walls)
- NAG - NAM NAG - NAM
- - *->@--*->@--*->@--*->@
- NAG - NAM - NAG - NAM
- * = enzymes that put cell wall together
- @ = β lactam that binds to enzymes and stops it.
- This causes cell wall to explode.
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