AA catabolism and Urea cycle.txt

Why do we need to remove Nitrogen from AA?

Nitrogen containing compounds can't be digested in the liver
Where does the urea cycle occur?

Liver only
What is the role of glutamate dehydro?
- Remove NH₃ from glutamate using NAD⁺
- Make Glutamate from alpha-ketoglut. using NADPH + NH₃
How many ATP required for one Urea molecule?

4 ATP
Where is CPS-1 found?

Liver
What mops up the extra ammonia after the Urea cycle is finished?
- Glutamine synthetase (to form glutamine)
- Low Vmax, Low Km
Why is Ammonia so dangerous?
- It can cross the BBB and can increase glutamine in the brain
- Leads to encephalopathy

Author

kepling

43807

Card Set

AA catabolism and Urea cycle.txt

Description

AA catabolism and Urea cycle

Updated

2010-10-20T21:43:55Z

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