1. Cholesterol is a precursor for what three components?
    • Cell membrane
    • Vitamin D
    • Steroid hormones
  2. What are the three methods of cholesterol influx?
    • Dietary
    • extrahepatic synthesis
    • de novo synthesis
  3. What are the 3 methods for cholesterol excretion?
    • Bile salts/acids
    • VLDL
    • free cholesterol in bile
  4. What are the two methods in activating the RLE, HMG CoA Reductase?
    • Low cholesterol
    • Insulin
  5. What are the two jobs on intestinal flora on bile salts?
    • Deconjugate = back to bile acids (cholic, chenodeoxycholic)
    • Dehydroxylate = secondary bile acids (deoxycholic, litholic)
  6. What are the two conjugates added to bile acids to form bile salts?
    • Glycine = glycocholic acid
    • Taurine = taurochenodeoxycholic acid
  7. What percentage of bile salts secreted into the intestine are reabsorbed as mixed bile salts/acids?
  8. What is the job of a resin during cholsterol control?
    to block reabsorption of bile salts so the liver has to use more cholesterol to synthesize more bile salts for use
  9. What is cholelithiasis?
    • Gallstones from cholesterol deposition
    • not enough bile acids to help solubilize the bile salts, overproduction of bile salts, too much cholesterol
Card Set
cholesterol synthesis