-
Location of splenic vein (with respect to splenic artery)
Posterior, inferior
-
Organ that is the largest producer of IgM
Spleen
-
Filter for aged or damaged RBCs
Red pulp
-
Removal of abnormalities in RBC membranes (job of the spleen)
Pitting
-
Nuclear remnants in RBCs
Howell Jolly bodies
-
Hemoglobin deposits in RBCs
Heinz bodies
-
Portion of spleen containing lymphocytes and macrophages
White pulp
-
Site of spleen that does bacterial clearance (that lack pre-existing antibodies)
White pulp
-
Blood supply to spleen
Splenic artery, short gastrics, left gastroepiploic
-
An opsonin that facilitates phagocytosis
Tuftsin
-
An enzyme that activates alternative complement pathway
Properdin
-
Most common location for accessory spleen
At splenic hilum
-
Most common nontraumatic condition requiring splenectomy
ITP
-
Disease with antiplatelet antibodies, petechiae, gingival bleeding, bruising
ITP
-
Medical treatments for ITP
Steroids, plasmapheresis, gammaglobulin (if steroid resistant)
-
Disease with loss of platelet inhibition leading to thrombosis and infarction plus thrombocytopenia, fevers, mental status changes, renal dysfunction
TTP
-
Treatment of TTP
Plasmapheresis, steroids, ASA
-
Bacteria causing postsplenectomy sepsis syndrome (3)
S. pneumoniae, H. influenzae, N. meningitides
-
Vaccines needed before splenectomy
Pneumococcus, meningococcus, H. influenzae
-
Changes in CBC post splenectomy
Inc RBCs, inc WBCs, inc platelets
-
Most common splenic tumor
Hemangioma
-
Most common malignant splenic tumor
nonHodgkin's lymphoma
-
indication for removal of splenic cysts
symptomatic, >10cm
-
causes of secondary hypersplenism
inc venous pressure (portal HTN, CHF), cancer (leukemia), chronic inflammatory disease (Felty's syndrome, SLE, sarcoid), myeloproliferative disease, amyloidosis, AIDS, hemolytic anemias, polycythemia vera
-
indications for splenectomy associated with hypersplenism
ANY primary hypersplenism (rare), CLL, CML, NHL, Hodgkin's, hairy cell, hemolytic anemia, sarcoid
-
Rheumatoid arthritis, hepatomegaly, splenomegaly
Felty's syndrome
-
Lipid metabolism disorder leading to splenomegaly
Gaucher's disease
-
Most common congenital hemolytic anemia requiring splenectomy
Spherocytosis
-
Spectrin defect causing deformed RBCs and splenic sequestration
Spherocytosis
-
Treatment of spherocytosis
Splenectomy
-
Spectrin and protein 4.1 deficit causing deformed RBCs and splenic sequestration
Elliptocytosis
-
Congenital hemolytic anemia causing altered glucose metabolism
Pyruvate kinase deficiency
-
Congenital hemolytic anemia precipitated by infection, certain drugs, and fava beans
G6P deficiency
-
Replacement of HgbA with HgbS, causes splenic auto-infarction
Sickle cell anemia
-
Persistent fetal HgbF causing anemia, pallor, growth retardation, head enlargement
Thalassemias
-
Hodgkin's disease class A
Asymptomatic
-
Hodgkin's disease class B
Symptomatic (night sweats, fever, weight loss)
-
Hodgkin's disease with 2 noncontiguous areas on the same side of diaphragm
Stage II
-
Hodgkin's disease with involvement on both sides of the diaphragm
Stage III
-
Most common subtype of Hodgkin's disease
Nodular sclerosing
-
Cells seen on cytology for Hodgkin's
Reed Sternberg cells
-
Most common subtype of NonHodgkin's lymphoma
B cell lymphoma (90%)
-
Treatment of NHL
XRT, chemotherapy (vincrisine, cyclophosphamide, prednisone, Adriamycin)
-
Treatment of Hodgkin's lymphoma
XRT, chemotherapy (vincristine, cyclophosphamide, prednisone, procarbazine)
-
Causes of spontaneous splenic rupture (6)
Mononucleosis, malaria, sepsis, sarcoid, leukemia, polycythemia vera
-
Splenic implants, often caused by trauma
Splenosis
-
Most common cause of splenic artery or splenic vein thrombosis
Pancreatitis
|
|
