pyrimidine nucleotide synthesis.txt

What is the first pyrimidine formed?

Orotate
What is the first pyrimidine nucleotide formed?

OMP
What activates and inhibits CPSII?
- active = ATP, PRPP
- inhibit = UTP
What type of ribonucleosides are needed for DNA synthesis?

diphosphates (ADP, GPD, CDP, UDP)
What substrates can bind at the four substrate spots on Ribonucleotide reductase?
- ATP, dATP, dTTP, dGTP
- ATP = active
- dATP = inhibition
Why is ADA such a problem?
- Converts Adenosine into ribo/deoxyribo through salvage
- makes dATP which inhibits R.R. = lack of DNA production
What is tetrahydrofolate utilized for (2 items)?
- All purines
- only dTMP for pyrimidines
Why is folate deficiency dangerous?

There is a link to cancer b/c of a lack of dTMP and more dUTP being incorporated into DNA
What is the function of methotrexate?

Inhibit DHFR
What is the function of 5-fluorouracil?

inhibit ThySyn by becoming f-dUMP and competing
How does AZT Triphosphate work?

Inhibits DNA replication by competing with dTTP
What is the function of Trimethoprim?

Inhibit bacterial DHFR

Author

kepling

43584

Card Set

pyrimidine nucleotide synthesis.txt

Description

pyrimidine nucleotide synthesis

Updated

2010-10-20T02:52:56Z

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