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Salbutamol (Canada), albuterol sulfate
Trade name:
Ventolin
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Salbutamol
Class:
- bronchodilator
- beta2-selective adrenergic agonist (sympathomimetic)
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Salbutamol
Action:
- Selectively stimulates beta-adrenergic receptors of the lungs, uterus, and vascular smooth muscle
- Brochodilation results from relaxation of the vascular smooth muscles, which relieves bronchospasm and reduces airway resistance
- Higher doses will drive serum potassium (K+) into the cells.
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Salbutamol
Indications:
- Bronchospasm due to bronchial asthma
- chronic bronchitis and other chronic bronchopulmonary disorders
- Respiratory distress with bronchospasm
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Salbutamol
Contraindications:
Hypersensitivity
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Salbutamol
Adverse effects:
- Often dose-related and include
- restlessness, tremors dizziness, nausea, vomiting,
- palpitations, tachycardia, nervousness, peripheral vasodilation,
- hyperglycemia, increased blood pressure, and paradoxical bronchospasm.
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Salbutamol
Onset:
5-15 minutes
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Salbutamol
Duration
Duration: 3-4 hours Peak effect: in 30 minutes to 2 hours
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Salbutamol
Adult Dosage:
- 2.5 – 5.0 mg nebule – repeat q 10 minutes prn
- MDI minimum 6 puffs max 20
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Salbutamol
Pediatric Dosage:
- 0.15 mg/kg diluted to 2.5 ml saline via nebulizer
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- < 10 kg give 1.25 mg with NS to 2.5 ml
- 10-20 kg give 2.5 mg
- > 20 kg give 2.5 – 5.0 mg
- MDI pediatrics minimum 2 puff max 10
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Salbutamol
Route:
Nebulizer or metered dose inhaler
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Salbutamol
Interactions/Precautions:
- Should not be used with patients presenting with acute heart failure Cardiovascular disease – cardiac dysrhythmias, hypertension
- Diabetes mellitus – risk of drug induced hyperglycemia
- Hypokalemia – risk further reducing serum potassium levels and possible adverse cardiovascular events
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