ACP Dimenhydrinate

Gravol, Dramamine

• antiemetic,
• antihistamine
• anticholinergic
• antivertigo

Antiemetic/antivertigo: inhibits nausea and vomiting by centrally depressing sensitivity to the labyrinth apparatus that relays stimuli to the chemoreceptor trigger zone and stimulates the vomiting center of the brain

Nausea, vomiting

• Hypersensitivity (contains benzyl alcohol)
• Seizures
• Any condition which may be worsened by anti-cholinergic effects

• Can cause sedation
• dry mouth
• blurred vision
• urinary retention

Immediate

4-7 hours Peak :1-4 hours

• 25 – 50 mg slow IVP
• 50 – 10 mg IM
• Note: IV dose must be diluted with NS to 10 ml

• 1 mg/kg IM or slow IVP (diluted)
• 2 – 5 years do not exceed 25 mg
• 6 – 12 years do not exceed 50 mg

Route: IV, IM

• Seizure disorders
• Asthma
• Patients with increased intraocular pressure or angle-closure glaucoma.
• Undiluted solution is irritating to the veins and may produce sclerosis