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ASA
Trade names:
Asprine, Alka Seltzer, Aspergum, Bayer, Cosprin....
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ASA
Class
- Anit-infammatory
- analgesic
- antipyretic
- platelet inhibitor
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ASA
Actions
- Anticoagulant:
- - at low doses, appears to impede clotting by blocking prostaglandin synthesis, which prevents
- formation of platelet-aggregating substance thromboxane A2
- Analgesia/anti-inflammatory:
- - inhibits the synthesis of prostaglandin, preventing or reducing pain (this is irreversible and can prolong bleeding time)
- Antipyretic:
- - acts on the hypothalamus to produce peripheral vasodilation causing sweating which leads to heat loss and cooling by evaporation
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ASA
Indications
Acute coronary syndroms suggestive of an acute myocardial infraction
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ASA
Contraindications
- Hypersensitivity
- GI bleeds
- ulcers
- asthma (May produce bronchoconstriction in asthmatics)
- unconsciousness
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ASA
Adverse effects
Heartburn, N/V, wheezing
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ASA
Duration
- Duration 1-4 hours,
- halflife 15-20min,
- peak effects 15min -2hrs
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ASA
Adult Dose
160mg - 325mg chewed as soon as possible
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ASA
Interactions-Precautions
- Anticoagulants increase risk of bleeding
- Impaired renal and hepatic function
- The effects of a single dose of aspirin persist for the life of the platelet (about 8 days)
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