What is the mechanism of action for AcE inhibitors?
Blocks the ACE, which prevents the conversion of Angiotensin I to Angiotensin II
What effect does blocking Angiotensin II have?
relaxes and expands vessels thus reducing blood pressure
Where do ACE inhibitors work?
What do ACE Inhibitors do?
lower blood pressure, treat heart failure, protect kidneys from damage (in patients with diabetes and hypertension), prevents early death in patients with hypertension
What are the side effects of ACE inhibitors?
build up of bradykinin which causes dry hacking cough, elevation of potassium levels, dizziness, low blood pressure, headache, angioedema
what is angioedema?
non-pitting edema that occurs as large erythematous areas in skin and sc tissues
Why are some experts recommending these medications for middle-aged diabetic patients with type-II diabetes?
they may slow the progress of diabetic kidney disease
ACE inhibitors are all very similar, but how do they differ from each other?
how they are eliminated from the body, their doses, some need to be converted into an active form in the body before they work, some may work more on ACE that is found in tissues than on ACE that is present in the blood
What patients are not advised to take ACE inhibitors and why?
Pregnant women (can cause birth defects), patients with severe renal disease (will not be able to be eliminated properly), patients on NSAIDS (may dimish the antihypertensive effects)