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Pain and Corticosteroids
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Mineralocorticoid (MC)
Na+ retaining
Increased Na+ = increased H20 = increased volume
Endogenous = aldosterone
Synthetic = fludrocortisone
Glucocorticoid (GC)
Glucose retaining
Endogenous = cortisol
Regulation of fat, carbs, protein metabolism
Naturally occurring = hydrocortisone and cortisone
Synthetic = prednisone
Corticosteroid: Mechanism of action
Intracellular binding leads to DNA transcription--> effect lags behind dosage (takes a while to elicit a response)
GC decreases inflammation and immune response by:
Inhibiting macrophage accumulation in inflamed areas
Decreased capillary permeability and edema formation
Antagonize histamine activity
Decrease immunoglobulins and passage of immune complexes via basement memb
Prevent release of destructive acid hydrolases from leukocytes
Fentanyl
Opioid agonist
:
Duragesic
Fentora
Actiq
Hydrocodone/Acetaminophen
Opioid agonist
:
Vicodin
Lorcet
Lortab
Hydromorphone
Opioid agonist
:
Dilaudid
Meperidine
Opioid agonist:
Demerol
Methadone
Opioid agonist
:
Dolophine
Morphine
Opioid agonist
:
MS Contin
Oramorph
Kadian, Avinza
Oxycodone
Opioid agonist:
OxyContin
Oxycodone/acetaminophen
Opioid agonist
:
Percocet
Endocet
Propoxyphene
Darvon
Propoxyphene/acetaminophen
Darvocet
Buprenorphine/Naloxone
Opioid Partial Agonist/Antagonist
:
Suboxone
Tramadol
Centrally acting analgesic
:
Ultram
Ryzolt
Methylprednisolone
GC
:
Medrol
Depo-Medrol
Solu-Medrol
Cortisone/ Hydrocortisone
GC
:
Short acting
T1/2 8-12 hrs
Na+ retaining
No anti-inflammatory
Equiv=25mg / 20 mg
Prednisone: Prednisolone
GC
:
Intermediate acting
T1/2 18-36 hrs
Moderate Na+ retaining (1)
Mod anti-inflamm (4)
Equiv=5mg
Triamcinolone
GC:
Intermediate acting
T1/2 18-36 hrs
No Na+ retaining
Moderate anti-inflamm (5)
Equiv=4mg
Methylprednisolone
GC
:
Intermediate acting
T1/2 18-36 hrs
No Na+ retaining
Moderate anti-inflamm (5)
Equiv = 4mg
Dosepak (TAPER)
Dexamethasone / Betamethasone
GC
:
Long-acting
T1/2 36-55 hrs
No Na+ retaining
HIGH anti-inflamm (20-30)
Equiv=0.75
CYP 450 enzyme induction
Decreased substrate in blood (drug removal)
CYP 450 enzyme inhibition
Increased substrate in blood (no breakdown)
P-glycoprotein (P-gp)
Efflux transporter
Excretion (decreased absorption)
Author
HuskerDevil
ID
40592
Card Set
Pain and Corticosteroids
Description
Pain and Corticosteroids
Updated
2010-10-08T02:05:45Z
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