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myel/o
bone marrow or spinal cord
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AIDS
acquired immunodeficiency syndrome
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ALT
alanine aminotransferase (enzyme)
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AST
aspartate aminotransferase (enzyme)
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BMP
basic metabolic panel
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CMP
comprehensive metabolic panel
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ESR
erthrocyte sedimentation rate
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HIV
human immunodeficiency virus
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MCH
mean corpuscular (cell) hemoglobin
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MCHC
mean corpuscular (cell) hemoglobin concentration
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MCV
mean corpuscular (cell) volume
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PET
positron-emission tomography
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PMN
polymorphonuclear (leukocyte)
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PTT
partial thromboplastin time
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RBC
red blood cell; red blood count
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WBC
white blood cell; white blood count
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plasma
liquid portion of the blood and lymph; contains water, proteins, and cellular components
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serum
liquid portion of the blood that remains after clotting
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erythrocyte
red blood cell; transports oxygen and carbon dioxide
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hemoglobin
the protein-iron cmpd in erythrocytes that transports oxygen and carbon dioxide
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leukocyte
white blood cell; protects the body from harmful invading substances
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granulocytes
a group of leukocytes containing granules in their cytoplasm
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neutrophil
a granular leukocyte, named for the neutral stain of its granules, that fights infection by swallowing bacteria
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polymorphonuclear (PMN) leukocyte
another term for neutrophil, referring to the many segments in its nucleus
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eosinophil
a granular leukocyte, named for the rose-colored stain of its granules, that increases in allergic and some infectious reactions
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basophil
a granular leukocyte, named for the dark stain of its granules, that brings anticoagulant substances to inflamed tissues
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agranulocytes
a group of leukocytes w/out granules in their nuclei
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lymphocyte
an agranulocytic leukocyte that is active in the process of immunity; the three categories of lymphocytes are T cells (thympus-dependent), B cells (bone marrow-derived), and natural killer (NK) cells
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monocyte
an agranulocytic leukocyte that performs phagocytosis to fight infection
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platelets
thrombocytes; cell fragments in the blood that are essential for blood clotting
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thymus
primary gland of the lymphatic system, located within the mediastinum, that helps to maintain the body's immune response by producing T lymphocytes
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spleen
organ between the stomach and the diaphragm that filters out agin blood cells, removes cellular debris by performing phagocytosis, and provides and environment for lymphocytes to initiate immune repsonses
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lymph
fluid that is circulated through the lymph vessels
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lymph capillaries
microscopic vessles that draw lymph from tissues to the lymph vessels
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lymph vessels
vessels that receive lymph from the lymph capillaries and circulate it to the lymph nodes
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lacteals
specialized lymph vessels in the small intestine that absorb fat into the bloodstream
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chyle
white or pale yellow substance in lymph that contains fatty substances absorbed by the lacteals
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lymph nodes
many small, oval structures that filter lymph from the lymph vessels; major locations include the cervical, axillary, and inguinal regions
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lymph ducts
collecting channels that carry lymph from the lymph nodes to the veins
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right lymphatic duct
receives lymph from the right upper party of the body
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thoracic duct
receives lymph from the left side of the head, neck, chest, abdomen, left arm and lower extremities
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immunity
process fo disease protection induced by exposure to an antigen
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antigen
a substance that, when introduced into the body, causes the formation of antibodies against it
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antibody
a substance produced by the body that destroys or inactivates an antigen that has entered the body
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active immunity
a long-lasting immunity that results from stimulation the body to produce its own antibodies; developed either naturally, in response to an infection, or artificially, in response to the administration of a vaccine
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passive immunity
a short-lasting immunity that results from foreign antibodies that are conveyed either naturally, through the placenta to a fetus, or artificially, by injection of a serum containing antibodies
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microcytosis
presence of small red blood cells
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macrocytosis
presence of large red blood cells
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anisocytosis
presence of red blood cells of unequal size
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poikilocytosis
presence of large, irregularyly shaped red blood cells
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reticulocytosis
an increased number of immature erythrocytes in the blood
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erythropenia
an abnormally reduced number of red blood cells
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lymphocytopenia
an abnormall reduced number of lymphocytes
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neutropenia
a decreased number of neutrophils
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thrombocytopenia
an abnormally decreased number of platelets in the blood impairing the clotting process
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hemolysis
breakdown of the red blood cell membrane
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immunocompromised
impaired immunologive defenses caused by an immunodeficiency disorder or by therapy with immunosuppressive agents
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immunosuppression
impaired ability to provide an immune response
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lymphadenopathy
enlarged (diseased) lymph nodes
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splenomegaly
enlargement of the spleen
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acquired immunodeficiency syndrome (AIDS)
a syndrome caused by HIV that renders immune cells ineffective, permitting opportunistic infections, malignancies, and neurologic diseases to develop; transmitted sexually or through contaminated blood.
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anemia
a condition of reduced numbers of red blood cells, hemoglobin, or packed red cells in the blood, resulting in a diminished ability of red blood cells to transport oxygen to the tissues
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aplastic anemia
a normocytic-normochromic type of anemia characterized by the failure of bone marrow to produce red blood cells
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iron deficiency anemia
a microcytic-hypochromic type of anemia characterized by a lack of iron that affects the production of hemoglobin and is characterized by small red blood cells containing low amounts of hemoglobin
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pernicious anemia
a macrocytic-normochromic type of anemia characterized by an inadequate supply of vitamin B12, causing red blood cells to become large, varied in shape, and reduced in number
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autoimmune disease
any disorder characterized by abnormal function of the immune system that causes the body to produce antibodies against itself, resulting in tissue destruction or loss of function, rheumatoid arthritis and lupus are examples of autoimmune diseases
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erythroblastosis fetalis
a disorder that results from the incompatibility of a fetus with Rh-positive blood and a mother with Rh-negative blood, causing red blood cell destruction in the fetus; a blood transfusion is necessary to save the fetus
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Rh factor
presence or lack of antigens on the surface or red blood cells, which causes a reaction between Rh-positive blood and Rh-negative blood
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Rh positive
presence of antigen
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Rh negative
absence of antigens
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hemochromatosis
hereditary disorder with an excessive buildup of iron deposits in the body
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hemophilia
a group of hereditary bleeding disorders cuased by a defect in clotting factors necessary for the coagulation of blood
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leukemia
chronic or acute malignant (cancerous) disease of the blood-forming organs, characterized by an abnormal leukocytes in the blood and bone marrow
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myelodysplasia
disorder within the bone marrow characterized by a proliferation of abnormal stem cells (cells that give rise to different types of blood cells); usually develops into specific type of leukemia
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lymphoma
any neoplastice disorder of lymph tissue, usually malignant, as in Hodgkin disease
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metastasis
process by which cancer cells are spread by blood or lymph circulation to a distant organ; plural form, metastases, indicates spreading to two or more distant sites
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mononucleosis
condition caused by the Epstein-Barr virus and characterized by an increase in mononuclear cells (monocytes and lymphocytes) in the blood along with enlarged lymph nodes (lymphadenopathy), fatigue, and sore throat (pharyngitis)
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polycythemia
increased number of erythrocytes and hemoglobin in the blood
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septicemia
systemic disease caused by infection with microorganisms and their toxins in circulating blood
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phlebotomy/ venipuncture
incision into or puncture of a vein to withdraw blood for testing.
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blood chemistry
test of the fluid portion of the blood to measure the amounts of its chemical constituents
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blood chemistry panels
specialized batteries of automated blood chemistry tests performed on a single sample of blood; used as a general screen for disease or to target specific organs or conditions
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basic metabolic panel (BMP)
battery of tests used as a general screen for disease; includes tests for calcium, carbon dioxide, chloride, creatine, glucose, potassium, sodium, and blood urea nitrogen (BUN)
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comprehensive metabolic panel (CMP)
tests performed in addition to the basic panel for expanded screening: albumin, bilirubin, alkaline phosphatase, protein, alanine aminotransferase (ALT), and asparate aminotransferase (AST)
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blood culture
test to determine if infection is present in the bloodstream by isolating a specimen of blood in an environment that encourages the growth of the microorganisms; the speciment is observed, and the organisms that grow in the culture are identified
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CD4 cell count
a measure of the number of CD4 cells in the blood; used in monitoring the course of HIV and in timing the treatment of AIDS; the normal adult range is 600-1500 cells in a given volume of blood
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erythrocyte sedimentation rate (ESR)
timed test that meausres the rate at which red blood cells settle through a volume of plasma
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partial thromboplastin time (PTT)
test to determine coagulation defects, such as platelet disorders
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thromboplastin
substance present in tissues, platelets, and leukocytes that is necessary for coagulation
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prothrombin time (PT)
test to measure activity of prothrombin in the blood
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prothrombin
protein substance in the blood that is essential ot the clotting process
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complete blood count (CBC)
a commom lab blood test performed as a screen of general health or for diagnostic purposes and typically includes the componenet tetsts that follow; test results are usually reported along with normal values so that the clinician can interpret the results based on the instrumentation used by the lab; normal ranges also may vary depending on the region and climate
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white blood count (WBC)
a count of the number of white blood cells in a given colume of blood obtained via manual or automated lab methods
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red blood count (RBC)
a count of the number of red blood cells in a given colume of blood obtained via manual or automated lab methods
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hemoglobin (HGB or Hgb)
a test to determine the blood level of hemoglobin (expressed in grams)
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hematocrit (HCT or Hct)
a measurement of the percentage of packed red blood cells in a given volume of blood
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blood indices
calculations of RBC, HGB, and HCT results to determine the avg size, hemoglobin concentration, and content of red blood cells to classify an anemia
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mean corpuscular (cell) columbe (MCV)
calculation of the volume (size) of individual red blood cells using HCT and RBC results MCV=HCT/RBC
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mean corpuscular (cell) hemoglobin (MCH)
calculation of the content (weight) of hemoglobin in the avg red blood cell using HGB and RBC results: MCH=HBG/RBC
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mean corpuscular (cell) hemoglobin concentration (MCHC)
calculation of the avg hemoglobin concentration in each red blood cell using HGB and HCT results: MCHC=HGB/HCT
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differential count
- determination of the number of each type of white blood cell (leukocyte) in a stained blood smear; each type is counted and reported as a percentage or the total examined
- lymphocytes 25-33%
- monocytes 3-7%
- neutrophils 54-75%
- eosinophils 1-3%
- basophils 0-1%
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red cell morphology
as part of identifying and counting the white blood cells, the condition, size, and shape of red blood cells in the background of the smeared slide are noted
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platelet count (PLT)
calculation of the number of thrombocytes in the blood; the normal adult range is 150,000-450,000 platelets in a given volume of blood
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bone marrow aspiration
needle aspiration of bone marrow tissue for pathologive examination
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bone marrow biopsy
pathologic examination of bone marrow tissue
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lymphangiogram
an x-ray image of a lymph node or vessel obtained after injection of a contrast medium
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computed tomography (CT)
full body x-ray CT images are used to detect tumors and cancers such as lymphoma
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positron-emission tomography (PET)
scanning technique combing nuclear mdicine and computed tomography technology to produce images of anatomy and metabolic function within the body; useful in determining the recurrence of cancers or to measure response to therapy; commonly used in evaluation lymphoma
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bone marrow transplant
transplantation of healthy bone marrow from a compatible donor to a diseased recipient to stimulate blood cell production
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lymphadenectomy
removal of a lymph node
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lymphadenotomy
incision into a lymph node
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lymph node dissection
removal of possible cancer-caryying lymph nodes for pathologic exam
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splenectomy
removal of the spleen
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thymectomy
removal of the thymus gland
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blood transfusion
introduction of blood products into the circulation of a recipient whose blood volume is reduced or deficient in some manner
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autologous blood
blood donated by and stored for a patient for future personal use
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homologous blood
blood voluntarily donated by any person for transfusion to a compatible recipient
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blood component therapy
transfusion of a specific blood component, such as packed red blood cells, platelets, or plasma
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cross-matching
method of matching a donor's blood to the recipient by mixing a sample in a test tube to determine compatibility
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chemotherapy
treatment of malignancies, infections, and other diseases with chemical agents to destroy selected cells or to impair their ability to reproduce
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immunotherapy
use of biologic agents to prevent or treat disease by stimulating the body's own defense mechanisms, as seen in the treatment of AIDs, cancer, or allergy
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plasmapheresis
removal of plasma from the body with separation and extraction of specific elements followed by reinfusion
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anticoagulant
a drug that prevents clotting of the blood
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hemostatic
a drug that stops the flow of blood within the vessels
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vasoconstrictor
a drug that causes a narrowing of blood vessels, thereby decreasing blood flow
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vasodilator
a drug that cuases dilation of blood vessels, thereby increasing blood flow
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