-
antidote for coumadin (anticoagulant warfarin)
vitamin k
-
deficiency primarily in chronic alcoholism
thiamine (vitamin B1)
-
given to prevent neurotoxicity
vitamin B6
-
antidote for iron
- deforoxamine (Desferal)
- *iron meds "ferrous" IRON-Fe
-
chelating agents
antagonists to metals, treat overdose/poisoning
-
antacids
- calcium->constipation
- magnesium->diarrhea
-
what decreases acid release?
histamine (H2) antagonists "tidine" family
-
what decreases HCL secretions more effectively?
- proton-pump inhibitors
- "prazole" family
-
Mucosa protectives
- carafate; dissolve, don't crush for NG
- cytotec-prevent NSAID induced ulcers
-
GI stimulant (prokinetic agent)
- SE: drowsiness, fatigue
- Reglan used as antiemetic
-
bismuth (primary ingredient in pepto bismol)
- antibiotic therapy for PUD
- -ulcer due to H.Pylori
-
Primary SE of antiemetic:
drowsiness
-
Nausea
- Antiemetics used to TREAT it
- serotonin used to PREVENT it
- (serotonin-"estrons" family)
-
Miscallaneous anti-emetics
- dronabil (Marino) contains THC
- scopolamine ("Scop Patch")-used to prevent motion sickness with anticholinergic effects
-
tegaserod (Zelnorm)
used for constipation IBS
-
ocetreotied (Sandostatin)
growth hormone suppressor that also suppresses GI -> antidiarrheal effect (used for severe diarrhea)
-
stool softener/surfactant
daily dose to prevent, not treat, constipation
-
contact/stimulant
treat constipation
-
bulk forming laxative
freq. used by elderly
-
osmotic laxative
- hypertonic substance that pulls flud into GI
- Milk of Magnesia
- Fleets enema
-
polyethylene glycol
requires 4L q 10min. (of fluids)
-
hepatic failure results in:
- hypoproteinemia, increased pressure within portal circulation, and increased levels of aldosterone->results in fluid retention(ascites)
- treat w/ potassium sparing diuretic
-
what regulates Na (sodium)?
aldosterone
-
lactulose
- 2-4Xdaily to get rid of ammonia
- once daily as a laxative
-
cholestyramine (Questran) "Bile Acid Sequestrant"
- lowers cholesterol
- be sure to let powder "settle" before stiring
-
normal urine output
- 2-21/2 L/day
- 1mL/kg/hr
- 60mL/hr
- BAD-<30ml/hr
-
most diuretics act on what system?
tubular->interferes w/ reabsorption of Na and Cl, thus excreting Na and H20
-
loop diuretics
- inhibit electrolye reabsorption in loop of Henle
- venodialate-so drug of choice for HF
-
furosemide (Lasix)
SE: ototoxicity, hyperglycemia, hyperuricemia (problems w/ gout pts) hypokalemia
-
thiazide & thiazide like diuretics
- 1st line recommendation for treatment for HTN
- hydrochlorothiazide "thiazide" family
-
osmotic diuretics
- mannitol *dissolve crystals before administration
- used to decrease cerebral fluid and manage intracranial pressure
-
carbonic anhydrase inhibitor diuretic
- decreases pressure in eye (glacoma)
- management of pt w/ metabolic alkalosis
-
potassium sparing
- SE: hyperkalemia
- diuretic of choice in liver failure pts
-
aquaretics
treatment of SIADH -syndrome of antidiuretic hormone
-
hyperkalemia
- kayexalate will wash it out
- give enemas to get kayexalate back
-
hyperphosphatemia
aluminum hydrodroxide antacids-rids of phosphorous
-
what rids phosphate?
calcium
-
sodium bicarb (NaHCO3)
helps w/ pts who have metabolic acidosis
-
urinary retention
alpha blocker prescribed
-
UTI's
- "azo" for dysuria ->will cause reddish-orange discoloration of urine
- "sulfa" antibiotics->anti-infective
-
IVP (Intravenous Pyelogram)
most commonly used radiological test to evaluate the urinary system
-
MRI
- 3-D (better pic.)
- NO metal objects allowed in room
-
Cation/anion balance
- extracellular: NA+, CL-
- intracellular: K+, Phosphate-
-
normal serum osmality
approximately 300 mOsm/L
-
hypertonic
- greater concentration of solutes (particles)
- pulls water into vascular compartments
- dehydrates cells
-
hypotonic
- less concentration of solutes
- pushes water out of intravascular compartments
- hydrates cells
-
lactated ringers
- isotonic fluid
- similar to plasma
-
albumin
- #1 protein in body
- must maintain normal amount
-
requires filters
blood, manitol, and parental nutrition
-
-
Calcium
8.5-10mg/dL or 4.5-5.5 mEq/L
-
-
-
hypercalcemia
- HYPOneuromuscular activity-muscle weakness, constipation, risk for kidney stones
- hyperparathyroidism-long term or high doe of antacid use
-
hypocalcemia
- HYPERneuromuscular activity-muscle spasms, seizures
- hypoparathyrodism
- complication of renal failure, panctreatitis, rapid blood transfusion, vitamin D deficient
-
hypomagnesemia
- malnutrition (chronic alcoholism)
- prolonged diarrhea
- HYPERneuromuscular activity
-
hypermagnesemia
- poor renal function
- intake of magnesium containing antacids
- HYPOneuromuscular activity
-
Antidote for Magnesium toxicity
calcium
-
hyperphosphatemia
- chronic renal failure
- HYPERneuromuscular
- treat w/ aluminum antacids
-
hypophosphatemia
- malnutrition
- hyperparathyroidism
- HYPOneuromuscular activity
-
Barium
- for GI X-rays
- turns stool chalky white
- make sure pt is excreting it
-
contrast dyes
- kidney dysfunction
- encourage fluids
-
metformin
diabetic pt. stop taking prior to recieving contrast dyes to decrease risk of lactic acidosis
-
positive TB
- indiration of 10mm or more in immunocompromised pt.
- indiration of 5mm is considered positive
-
radioactive substances
body fluids may be radioactive
-
lymph node mapping
- injection of dye to identify lymph node involement in metastatic cancer
- dye turnes urine bright turquoise
-
plasma-interstitial: edema
- ^venous hydrostatic pressure
- decreased plasma oncotic pressure
- ^interstitial oncotic pressure
- decreased lymphatic outflow
-
interstitial to plasma
- ^plasma osmotic-oncotic pressure
- ^tissure hydrostatic pressure: TED hose
- hypovolemic shock
-
hydrostatic pressure at arterial end
40mmHg
-
oncotic pressure (a.k.a. colloidal osmotic pressure)
-
hydrostatic pressure at venous end
10mmHg
-
factors that increase release of ADH
- increased plasma osmolality
- decreased circulating volume
- decreased stress and pain
- medications/surgery
- positive pressure ventilators
-
factors that decrease ADH
- decreased plasma osmolarity
- increased effective circulating volume
- increased BP
- medications (Dilantin)
-
Hyponatremia
- lack of aldosterone-^ renal sodium loss
- lack of cortisol- ^release of ADH
- thiazide (NSAID's)-decrease Na+
-
Hypernatremia
- kayexalate has ^Na+
- diabetic pts can't excrete Na+
-
in Hypokalemia ALKALOSIS
hydrogen ions shift out of cells and potassium from ECF shifts into cells
-
Trousseu's sign
muscle spasm (in arm)
-
Chvostek's sign
cheek spasm
-
thiazide & lithium
decreases renal calcium excretion
-
-
-
-
metabolic acidosis
- SX: disorientation
- kussmal resp.
- muscle twitching
- changes in LOC
- decreased pH
- decreased HCO3
-
metabolic alkalosis
- SX: nausea & vomiting
- diarrhea
- restlessness
- slow resp.
- arrhythmias
- ^pH
- ^HCO3
-
respiratory acidosis
- SX: rapid, shallow resp.
- dyspmea
- disorientation
- muscle weakness
- decreased pH
- ^pCO2
-
respiratory alkalosis
- SX: tingling of extremities
- confusion
- deep-rapid breathing
- seizures
- ^pH
- decreased pCO2
-
ROME
- R espiratory
- O pposite
- M etabolic
- E qual
-
Colloids
*volume expanders*
- Albumin 5% or 25%
- Hetastarch
- Dextran
-
-
beta 2 selective
abluterol-most common used inhaler
-
Xanthines (methlyxanthine)
- similar to caffeine effects (bronchodialating)
- "phylline" family
- therapeutic level 10-20 mcg/mL **
-
leukotriene antagonists
- asthma prophylaxis
- "lukast" family
- inhibits inflammation
-
intranasal gluccocorticoids
most effective for allergic rhinitis
-
antihistamines
anticholinergic (short acting)
-
peripheral acting histamines
- non-sedating
- "ine" family
-
First Line Drug:
INH (isoniazid)
- SE: neurotoxicity
- B6 given to prevent
-
First Line Drug:
rifampin
turns body fluids reddish orange
-
-
beta adrenergic
long acting
-
serevent
- short acting
- alupent, proventil, maxair
-
ventilation
mechanism of body to inspire and expire air
-
respiration
involves a 3 phase process
-
atmospheric pressure
- 760mmHg
- +4 for expiration (764)
- -6 for inspiration (754)
-
atmospheric air
- 21% Oxygen
- 78% Nitrogen
- 1% other gases
-
-
-
-
-
Respiratory sounds
- vesicular: I>E
- bronchovesicular: I=E
- bronchial: I<E
-
compliance (distensibility)
amount of movement of chest when breathing
-
diffusion
gases moving from higher to lower concentration
-
-
platelet count norms
150,000-400,000/mm3
-
glucose norms
70-110 mg/dL
-
-
Creatinine norms
- M: 0.6-1.2 mg/dL
- F: 0.5-1.1 mg/dL
-
-
-
normal ejection rate
- 60-70%
- 70 bpm
- 70 mL of blood
- =4.9 L CO (cardiac output)
-
loss of water
- isotonic: normal loss
- hypotonic: less than 135mEq/dL-loss of Na & H2O
- hypertonic: more than 145mEq/dL-excess Na, decreased H2O
-
what most likely causes FVE (fluid volume excess)?
blood
-
what is the main sign of FVE?
SOB
-
calcium and phosphorous are interrelated
- ^calcium, decrease phosphorous
- decrease calcium, ^phosphorous
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