Whats the relationship between splenic vein and artery?
the splenic vein is posterior and inferior to the splenic artery
Name a function of the spleen (immunologic):
spleen serves as an antigen-processing center for macrophages; largest producer of IgM
Red pulp:
1) 85% of spleen
2) acts as a filter for aged or damaged RBCs
3) Pitting- is the removal of abnormalities in RBC membrane
-Howell- Jolly bodies- nuclear remnants
-Heinz bodies- hemoglobin
4) Culling- removal of less deformable RBCs
White pulp:
1) spleen is 15% white pulp
2) immunologic function; contains lymphocytes and macrophages
3) major site of bacterial clearance that lacks preexisting antibodies4) site of removal of poorly opsonized bacteria, particles, and cellular debris5) antigen processing occurs with interaction between macrophages and helper T cells
Tuftsin-
an opsonin, facilitates phagocytosis --> produced in spleen
Properidin:
activates alternative complement pathway- produced in the spleen
Hematopoesis
occurs in spleen before birth and in conditions like myeloid dysplasia
Accessory spleen
most commonly found at splenic hilum (20%)
Indication for splenectomy:
ITP far greater than TTP
- ITP most common nontraumatic condition requiring splenectomy