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Antimicrobial Drugs
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Antibiotics
A substance produced by a microbe that inhibits the growth of other microbes
Most antibiotic-producing microbes have a sporulation process
Antibiotic Sensitivity
Sensitivity depends upon:
LPS
: helps exclude large or hydrophobic molecules
Porins
: exclude large hydrophobic molecules
Antibiotics can inhibit normal intestinal flora
Can lead to a proliferation of other microbes
Superinfection
Penicillin
Penicillin is a Competitve Inhibitor
Penicillinase breaks the B-lactam ring
Gm- are resistant to Penicillin
Macrolides
Block the space (“tunnel”) through which mRNA feeds on ribosome
Inhibits protein synthesis
3. Injury to Plasma Membrane
Bacterial division requires elongation of plasma membrane
Inhibitors of fatty acid synthesis; inhibits growth
4. Inhibitors of Nucleic Acid Synthesis
DNA or RNA inhibitors
The topoisomerase makes it easier for the helicase to go through. Quinolones stop the topoisomerase.
5. Inhibiting Synthesis of Essential Metabolites
Usually competitive inhibitors
Drug Resistance
3 categories. Eflux Pump. Every bacteria cell has an eflux pump. It gets in but the pump pumps it back out.
Antibiotic degrading enzyme breaks up the antibiotic
Antibiotic altering enzyme alters the structure of the antibiotic which makes it useless
Mechanisms of Resistance
Enzymatic Destruction or Inactivation of drug
Prevention of penetration to target site within microbe
Alteration of drug target site (e.g. surface protein)
Rapid efflux of antibiotics
Author
bamerb07
ID
38332
Card Set
Antimicrobial Drugs
Description
Svinth Micro quiz
Updated
2010-09-29T14:02:50Z
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