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AML M0
- Blasts have no differentiating features morph, no visible granules in blast cytoplasm
- PDX & SBB: negative
- CD13+, CD33+, CD34+,CD117+
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AML M1
- No maturation beyond blasts, >90% blast in marrow space, pro,myelo, n auer mayb present
- Myeloperoxidase & SBB: positive
- CD13+, CD33+, CD34+, CD117+
- Usually adults and <1 yrs old
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AML M2
- >20% Myeloblasts of nonerythroid cell in marrow, large blast mayb w/ azurophilic granules
- See maturation to promyelo and beyond
- Auer rods mayb seen, mayb Phi bodies
- Adults are common
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APL M3
- Promyelocyte are dominant
- Intense azurophilic granulation
- May see Auer rods
- Myeloperoxidase & SBB: intensely positive
- t(15;17) affects retinoicacid receptor: Retinoic acid therapy (ATRA)may induce maturation ofcells
- DIC possible: by granular procoagulants
- Young adults, elderly (women more)
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