WHO AML Classification

  1. AML with Recurrent Abnormal Karyotypes
    • -AML w/t(8;21)(q22;q22), AML1(CBFa/ETO)
    • -AML w/ t(15:17)(q22;q12), (PML/RARa)
    • -AML w/ inv (16)9p13q22) or t(16:16)(p12:q22), (CBLb/MYH11)
    • -AML w/ 11q23 (MLL) abnormalities
  2. AML with Multilineage dysplasia
    AML with Multilineage dysplasia
  3. AML as a Result of Previous Therapy
    AML as a Result of Previous Therapy
  4. AML Not Otherwise Categorized
    FAB M0-M7 Except of M3
  5. Acute Leukemia of Ambiguous Lineage
    Acute Leukemia of Ambiguous Lineage
  6. AML with Recurrent Abnormal Karyotypes
    • AML w/t(8;21)(q22;q22), AML1(CBFa/ETO): Looks like AML with maturation, Myeloblasts, Auer Rods
    • AML w/ t(15:17)(q22;q12), (PML/RARa): Acute promyelocytic leukemia
    • AML w/ inv (16)9p13q22) or t(16:16)(p12:q22), (CBLb/MYH11): like acute myelomonocytic leukemia with immature, abnormal eosinophils in the marrow
    • AML w/ 11q23 (MLL) abnormalities: Morphologically associated with monocyte abnormalities
Author
missnguyen
ID
38258
Card Set
WHO AML Classification
Description
Heme AML
Updated