platelet adhesion to exposed collagen within the endothelial of the vessel wall. However, will be ineffective over time, requires 2nd response.
ezymatic activation of coagulation cascade which stabilizes fragile clot formed during primary hemostasis.
What component when initial response is vasoconstriction, reducing blood flow past site of injury.
What component when aggregation of platelets at injured site due to collagen exposure
What component when coagulation factors-coagulation cascade activated due to blood vessel injury.
What component is when stable clot is dissolved
What charge is endothelial cells?
negative-to repel platelets
What accelerates conversion of plasminogen to plasmin?
Tissue plasminogen activator (TPA)
About how long does platelets stay in circulation?
What is the normal peripheral count of platelets?
What is the function of the peripheral of platelets?
adhesion and aggregation
What is the function of sol-gel?
contraction and support
What is the function of the platelet organelle?
Storage and secretion of granule contents
What two glycoproteins are missing in BSS?
GPIb and GPV
What two plt glycoproteins are missing in Glanzmann's?
GPIIb and GPIIa
What systen in the Sol Gel zone causes surface membrane to increase to exocytose granule contents?
Open Canaliculi System
What protein allows for contraction of tubules?
What are the steps of platelet plug formation?
1. platelet adhesion
2. platelet aggregation
3. platelet plug
4. Fibrin stabilized
The release of what from dense bodies into sol gel causes contractile wave with release of ADP and serotonin resulting in plt aggregation and adhesion.
What does the endothelial cell release to act as a brigde between plt and subendotheium lining?
Where is thrombaxane produced from?
What step does aspirin inhibit in the thromboxane A2 pathway?
What type of disease is Inherited Hemorrhagic Telangietasia?
Inherited Vascular Disorder (characterized by many small thin walled capillaries and small veins in mucosa. Plt function test and coagulation tests are normal)