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- Osteosarcoma
- Neoplastic spindle cells seen making pick osteoid here
- Osteiod production by a sarcoma is diagnostic of osteosarcoma
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- Ductal carcinoma of the breast
- Central area of desmoplasia
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- Fibroadenoma compressing ducts surronded by fibrous stroma
- Lesions would be likely found as breast lump on exam of young women.
- Discrete, rubbery masses that are freely movable
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- Squamous cell carcinoma
- Disorderly growth of squmous epithelial cells in these large nests with pink keratin in the center
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- Normal cervical squamous epithelium at left
- Dysplastic squamous epithelium at right (cells more disorderly)
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- Normal cervial squamous epithelium on left
- Dysplastic squamous epithelium at right
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- NHL - large cell lymphoma
- Cells large, prominant nucleoli, abundant cytoplasm
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- On left is normal liver tissue with portal tract
- On right is hepatic adenoma composed of cells that closely resemble normal hepatocytes
- Neoplastic liver tissue disorganized, normal lobular architecture not present
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- Malignant cells of hepatocellular carcinoma on right
- Well differentiated and interdigitate with normal, larger hepatocytes on left (normal)
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Metastatic adenomcarcinoma in lymph node
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- Squamous cell carcinoma with nests of polygonal cells with pink cytoplasm and distinct cell borders
- Nuclei hyperchromatic and angular
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- Renal cell carcinoma
- Neoplastic cells have clear cytoplasm and are arranged in nests with intervening blood vessels
- "clear cell carcinoma"
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- Malignant melanoma
- Large polygonal cells (or spindle cells) havce pleiomorphic nuclei which contain prominent nucleoli
- Neoplasm is making brown melanin pigment
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- the normal colonic epithelium at the left contrasts with the atypical epithelium of the adenomatous polyp at the
- right. Nuclei are darker and more irregularly sized and closer together in the adenomatous polyp than in the normal mucosa. However, the overall difference between them is not great, so this benign neoplasm mimics the normal tissue quite well and this, therefore, well-differentiated.
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