Vickroy Pharm drugs-ans

• muscarinic and nicotinic agonist (para and symp)
• side effects:
• Vasodilation, bradycardia, ↑ contractility, cramping, nausea, vomiting, defecation, urinary incontinence, bronchoconstriction,
• ↑ mucus secretion, CNS excitation

• Muscarinic agonist-cardiovasc. inhib
• feline bladder atony
• GI/urinary obstruction, questionable GI or UG wall integrity
• atropine

• mixed alpha and beta agonist
• anaphylactic shock, cardiopulmonary arrest, with local anesthetic for vasoconstriction, bronchiole dilation, reverse hypotension/maintain BP

• CHF, hypovolemic shock, hyperthyroidism, coronary dz, DO NOT GIVE TO ANIMALS THAT HAVE HAD ACEPROMAZINE
• alpha blocker (phentolamine); beta blocker (propanolol)

• Mixed alpha and beta 1 agonist
• maintain BP during acture hypotensive crisis
• shock, hypertension, hyperthyroidism, arteriosclerosis, coronary dz, nephritis

• alpha 1 antagonist
• vasodilation, urethral obstruction
• hypovolemic shock

• alpha 2 agonist
• sedative/analgesic (esp horses-CNS effects) emetic (esp cats)
• liver

• ventricular arrhythmias, seizures, foals, pregnant
• catecholamine-induced dysarrhythmias, depression of swallowing and gastric secretions, decrease BP=AV block
• Yohimbine

• Beta 1 agonist
• control arrhythmias, combo treatment for CHF, decrease HR
• AV block (bradyarrhythmia
• bradycardia=tx atropine

• muscarinic/nicotinic agonist
• hypotensive effect, rumen atony, equine colic, constipation/impaction
• NOT administered IV, resistant to cholinesterase hydrolysis
• atropine

Glycopyrrolate= less CNS penetration and tachycardia, longer half-life, more expensive, doesn't cross BBB, liver metabolism

• muscarinic antagonist
• antagonize Ach, preanesthetic-decrease secretions, prevent heart block by cardiac depressants, antispasmotic, organophosphate poisoning

• fever, colic, glaucoma
• dry as a bone, red as a beet, and mad as a hatter (similar to sympathetic hypersensitivity)

• mixed alpha agonist
• increased BP in hypotensive crisis w/o cardiastimulation
• hypertension, tachycardia

• mixed beta antagonist
• control arrhythmias, increase AV conduction
• bronchoconstriction (from beta 2)
• heart failure, asthma, insulin-dependent diabetes ** withdraw gradually-receptor upregulation

• alpha 2 antagonist
• xylazine and other alpha 2 agonist reversal
• seizure prone K9s, renal dz

• muscarinic antagonist, crosses BBB
• antagonize Ach, preanesthetic (decrease secretions, maintain HR)
• prevent heart block by cardiodepressants, Tx of organophosphate poisoning

• fever, colic, glaucoma
• dry as a bone, red as a beet, and mad as a hatter

• beta 1 agonist, similar to dopamine
• maintain BP, control localized bleedine/perfusion, **restore cardiac fxn, shock
• CHF, short half-life, not effective PO

• mixed beta agonist
• bronchoconstriction tx
• tachycardia, AV block
• increases HR, systolic P, decreases diastolic P=decrease BP

• mixed alpha antagonist
• decrease BP, xylazine reversal
• hypovolemic shock
• postural hypotension w/ reflex tachycardia, GI irritability, CNS depression/sedation, impotence

• beta 2 agonist
• asthma Tx, bradycardia Tx
• hypotension; rapid first pass effect

• short actine, reversible AChE inhibitor
• reversal of curare OD, dDx of muscle weakness, miosis, decrease IOP (glaucoma)

• AChE inhibitor
• CNS activity, glaucoma, treat myasthenia gravis, ruminal/GI stimulant, reverse muscle relaxants

• long lasting, reversible AChE Inhibitor
• glaucoma, treat myasthenia gravis, ruminal/GI stimulant, reverse muscle relaxants, doesn't cross BBB
• nausea, vomiting, diarrhea, salivation, sweating, miosis, hypotension, bradycardia, bronchospasm

• reactivates phosphorylated forms of AChE
• KNOWN organophosphate poisoning
• carbamate poisoning

• organophosphates inhibit the action of acetylcholinesterase.
• Txs: Praladoxime, glycopyrrolate,

• irreversible organophosphate AChE inhibitor
• organophosphate poisoning
• SLUD, Toxic