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What is the shelf life (closed and open) of whole blood
- closed: depends on preservative 21-42 days
- open:24 hours
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What is the shelf life (closed and open) of packed rbcs
- closed: depends on preservative (21-42 days)
- open: 24 hours
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What is the shelf life (frozen and thawed) of FFP
- frozen: 1 year
- thawed: 24 hours in 37 degree water bath
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What is the shelf life (frozen, thawed and single/pooled open) of cryoprecipitate?
- frozen: 1 year
- thawed and not entered: 6 hours
- open: 4 hours
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What is the shelf life (closed and open) of random platlets?
- single/random closed: 5 days
- open: 4 hours
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What is the shelf life (closed and open) of pheresis single donor platelets?
- closed: 5 days
- open: 4 hours
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What is the shelf life of pheresis granulocyte concentrates?
24 hours
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What is the storage and transportation temperature of granulocyte concentrates?
20-24 degrees on gel packs
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What is the storage and transportation temperature of cryoprecipitate?
- stored at -18 degrees
- thawed 20-24 degrees
- transport on dry ice for frozen and gel packs for thawed
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What is the storage and transportation temperature of random plts?
- stored 20-24 degrees with agitation
- transported 20-24 degrees in between 2 gel packs-max of 24 hours ( closed)
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What is the storage and transportation temperature of single donor plts?
opened or closed: 20-24 hours with agitation
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What is the storage and transportation temperature of FFP?
- frozen: -18 degree storage
- thawed: 1-6 degrees
- transport on dry ice -18 degrees (frozen)
- transport on wet ice 1-10 degrees (thawed)
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What is the storage and transportation temperature of whole blood?
- 1-6 degrees storage
- 1-10 degrees transport within 24 hours on wet ice.
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What is the storage and transportation temperature of packed rbc?
- store 1-6 degrees within 8 hours collection
- transport 1-10 degrees 24 hours on wet ice
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Therapeutic uses of whole blood
- rarely used
- in cases of symptomatic anemia with Large volume loss
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Therapeutic uses of packed rbc
- symptomatic anemia NOT corrected by specific meds
- blood loss
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Therapeutic uses of FFP
- 1. multiple coag factor deficiency : liver dz & DIC
- 2. TTP: thrombotic thromocytopenic purpura
3. Not for volume therapy or coagulopathy if treatable with meds
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Therapeutic uses of cryo
- control bleeding associated with:
- 1. hypofibrinogenemia
- 2. von willebrands dz
- 3. factorVIII deficiency-hemophilia A
- 4. Factor XIII deficiency
- 5. fibrin glue-topical
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Therapeutic uses of granulocyte concentrates
- 1. severe neutropenia
- 2. bacterial or fungal infection not treatable with antibiotics
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Therapeutic uses of random plts
- correct thromocytopenia due to decreased fxn, production or consumption
- bleeding
- dic
not for itp, ttp or sepsis--heat destroys plts
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Therapeutic uses of single donor plts
- correct thromocytopenia due to decreased fxn, production or consumption
- bleeding
- dic
not for itp, ttp or sepsis--heat destroys plts
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Expected therapeutic benifits of single donor plts
1 unit increases plt count 30-60,000 (equivalent to 6 randoms)
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Expected therapeutic benifits of random plts
1 unit increases plt count 5-10,000
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Expected therapeutic benifits of cyro
one IU increases factor VIII/Kg of body weight by 2%
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Expected therapeutic benifits of granulocytic concentrations
none listed
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Expected therapeutic benifits of whole blood
increases Oxygen and volume expansion
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Expected therapeutic benifits of packed RBCs
- increase oxygen
- 1 unit will increase Hgb by 1g/dL or by 3%
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Expected therapeutic benifits of FFP
increase factor levels by 20-30% per dose of 10-15 mL/Kg of body weight
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Compatibility testing and Administration of FFP
- no xmatch
- need ABO/plasma compatible
- Administer: thawed in 37 degrees within <4 hours
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Compatibility testing and Administration of whole blood
- must x match and ABO compatible
- admin: as fast as patient can tolerate with in 24 hours
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Compatibility testing and Administration of rbcs
- must be xmatched and ABO compatible
- Rh negs cells for Rh neg patients
- Admin: <4 hours as fast as patient can handle
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Compatibility testing and Administration of random plts?
- no xmatch
- abo compatible
- admin: <4 hours 1 unit/Kg of body weight
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Compatibility testing and Administration of single donor plts
- no xmatch, abo compatible
- maybe: HLA on plts may be match to pt, may need xmatch if containing . 5 mLs of RBCs
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Compatibility testing and Administration of cryo
- no xmatch, ABO compatible, Rh not required
- admin <4 hours in intervals
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Compatibility testing and Administration of granulocyte concentrates
- x match, abo compatible & irradiated '
- admin asap: 2-4 hours
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