1. Home
2. Flashcards
3. Preview

Oncogenes, Mode of Activation, and Associated Human Tumors

Home Get App Take Quiz Create growth factor  PDGF-β what proto-oncogene? PDGFB fibroblast growth factors what proto-oncogene? HST1 FGF3 growth factor TGF-α what proto-oncogene? TGFA growth factor HGF what proto-oncogene? HGF EGF receptor family what proto-oncogene? ERBB1 (EGFR) ERBB2 (HER) FMS-like tyrosine kinase 3 what proto-oncogene? FLT3 Receptor for neurotrophic factors what proto-oncogene? RET PDGF receptor what proto-oncogene? PDGFRB Receptor for KIT ligand what proto-oncogene? KIT ALK receptor what proto-oncogene? ALK GTP-binding (G) proteins what proto-oncogene? KRAS HRAS NRAS GNAQ GNAS Nonreceptor tyrosine kinase what proto-oncogene? ABL RAS signal transduction what proto-oncogene? BRAF Notch signal transduction what proto-oncogene? NOTCH1 JAK/STAT signal transduction what proto-oncogene? JAK2 Transcriptional activators what proto-oncogene? MYC NMYC Cyclins what proto-oncogene? CCND1 cyclin-dependent kinase what proto-oncogene? CDK4 proto-oncogene: PDGFB what activation and tumor? Overexpression Astrocytoma proto-oncogene: HST1 what activation and tumor? Overexpression Osteosarcoma proto-oncogene: FGF3 what activation and tumor? Amplification Stomach cancer Bladder cancer Breast cancer Melanoma proto-oncogene: TGFA what activation and tumor? Overexpression Astrocytomas proto-oncogene: HGF what activation and tumor? Overexpression  Hepatocellular carcinoma  Thyroid cancer proto-oncogene: ERBB1 (EGFR) what activation and tumor? Mutation Adenocarcinoma of lung proto-oncogene: ERBB2 (HER) what activation and tumor? Amplification Breast cancer proto-oncogene: FLT3 what activation and tumor? Point mutation or small duplications Leukemia proto-oncogene: RET what activation and tumor? Point mutation Multiple endocrine neoplasia 2A and B Familial medullary thyroid carcinomas proto-oncogene: PDGFRB what activation and tumor? Amplification, translocation Gliomas,  Leukemias proto-oncogene: KIT what activation and tumor? Point mutation Gastrointestinal stromal tumors, seminomas, leukemias proto-oncogene: ALK what activation and tumor? Translocation: Adenocarcinoma of lung, Lymphomas Point mutation: Neuroblastoma proto-oncogene: KRAS what activation and tumor? Point Mutation Colon, lung, and pancreatic tumors proto-oncogene: HRAS what activation and tumor? Point Mutation bladder and kidney tumors proto-oncogene: NRAS what activation and tumor? Point Mutation Melanomas, hematologic malignancies proto-oncogene: GNAQ what activation and tumor? Point mutation Uveal melanoma proto-oncogene: GNAS what activation and tumor? Point mutation pituitary adenoma, endocrine tumors proto-oncogene: ABL what activation and tumor? Translocation Chronic myelogenous leukemia Acute lymphoblastic leukemia proto-oncogene: BRAF what activation and tumor? Point mutation Melanomas, leukemia, colon carcinoma proto-oncogene: NOTCH1 what activation and tumor? Point mutation, translocation Leukemias, lymphomas, breast carcinoma proto-oncogene: JAK2 what activation and tumor? Point mutation, translocation Myeloproliferative disorders Acute lymphoblastic leukemia proto-oncogene: MYC what activation and tumor? Translocation Burkitt lymphoma proto-oncogene: NMYC what activation and tumor? Amplification Neuroblastoma proto-oncogene: CCND1 (Cyclin D1) what activation and tumor? Translocation: Mantle cell lymphoma, multiple myeloma Amplification: Breast and esophageal cancers proto-oncogene: CDK4 what activation and tumor? Amplification or point mutation  Glioblastoma, melanoma, sarcoma

Author eayilat_alghabat ID 365799 Card Set Oncogenes, Mode of Activation, and Associated Human Tumors Description Updated 2024-09-21T05:11:26Z Show Answers