Oncogenes, Mode of Activation, and Associated Human Tumors

  1. growth factor 
    PDGF-β

    what proto-oncogene?
    PDGFB
  2. fibroblast growth factors
    what proto-oncogene?
    • HST1
    • FGF3
  3. growth factor TGF-α

    what proto-oncogene?
    TGFA
  4. growth factor HGF

    what proto-oncogene?
    HGF
  5. EGF receptor family

    what proto-oncogene?
    • ERBB1 (EGFR)
    • ERBB2 (HER)
  6. FMS-like tyrosine kinase 3

    what proto-oncogene?
    FLT3
  7. Receptor for neurotrophic factors

    what proto-oncogene?
    RET
  8. PDGF receptor

    what proto-oncogene?
    PDGFRB
  9. Receptor for KIT ligand

    what proto-oncogene?
    KIT
  10. ALK receptor

    what proto-oncogene?
    ALK
  11. GTP-binding (G) proteins

    what proto-oncogene?
    • KRAS
    • HRAS
    • NRAS
    • GNAQ
    • GNAS
  12. Nonreceptor tyrosine kinase

    what proto-oncogene?
    ABL
  13. RAS signal transduction

    what proto-oncogene?
    BRAF
  14. Notch signal transduction

    what proto-oncogene?
    NOTCH1
  15. JAK/STAT signal transduction

    what proto-oncogene?
    JAK2
  16. Transcriptional activators

    what proto-oncogene?
    • MYC
    • NMYC
  17. Cyclins

    what proto-oncogene?
    CCND1
  18. cyclin-dependent kinase

    what proto-oncogene?
    CDK4
  19. proto-oncogene: PDGFB

    what activation and tumor?
    • Overexpression
    • Astrocytoma
  20. proto-oncogene: HST1

    what activation and tumor?
    • Overexpression
    • Osteosarcoma
  21. proto-oncogene: FGF3

    what activation and tumor?
    • Amplification
    • Stomach cancer
    • Bladder cancer
    • Breast cancer
    • Melanoma
  22. proto-oncogene: TGFA

    what activation and tumor?
    • Overexpression
    • Astrocytomas
  23. proto-oncogene: HGF

    what activation and tumor?
    • Overexpression 
    • Hepatocellular carcinoma 
    • Thyroid cancer
  24. proto-oncogene: ERBB1 (EGFR)

    what activation and tumor?
    • Mutation
    • Adenocarcinoma of lung
  25. proto-oncogene: ERBB2 (HER)

    what activation and tumor?
    • Amplification
    • Breast cancer
  26. proto-oncogene: FLT3

    what activation and tumor?
    • Point mutation or small duplications
    • Leukemia
  27. proto-oncogene: RET

    what activation and tumor?
    • Point mutation
    • Multiple endocrine neoplasia 2A and B
    • Familial medullary thyroid carcinomas
  28. proto-oncogene: PDGFRB

    what activation and tumor?
    • Amplification, translocation
    • Gliomas, 
    • Leukemias
  29. proto-oncogene: KIT

    what activation and tumor?
    • Point mutation
    • Gastrointestinal stromal tumors,
    • seminomas,
    • leukemias
  30. proto-oncogene: ALK

    what activation and tumor?
    • Translocation: Adenocarcinoma of lung, Lymphomas
    • Point mutation: Neuroblastoma
  31. proto-oncogene: KRAS

    what activation and tumor?
    • Point Mutation
    • Colon, lung, and pancreatic tumors
  32. proto-oncogene: HRAS

    what activation and tumor?
    • Point Mutation
    • bladder and kidney tumors
  33. proto-oncogene: NRAS

    what activation and tumor?
    • Point Mutation
    • Melanomas, hematologic malignancies
  34. proto-oncogene: GNAQ

    what activation and tumor?
    • Point mutation
    • Uveal melanoma
  35. proto-oncogene: GNAS

    what activation and tumor?
    • Point mutation
    • pituitary adenoma, endocrine tumors
  36. proto-oncogene: ABL

    what activation and tumor?
    • Translocation
    • Chronic myelogenous leukemia
    • Acute lymphoblastic leukemia
  37. proto-oncogene: BRAF

    what activation and tumor?
    • Point mutation
    • Melanomas, leukemia, colon carcinoma
  38. proto-oncogene: NOTCH1

    what activation and tumor?
    • Point mutation, translocation
    • Leukemias, lymphomas, breast carcinoma
  39. proto-oncogene: JAK2

    what activation and tumor?
    • Point mutation, translocation
    • Myeloproliferative disorders
    • Acute lymphoblastic leukemia
  40. proto-oncogene: MYC

    what activation and tumor?
    • Translocation
    • Burkitt lymphoma
  41. proto-oncogene: NMYC

    what activation and tumor?
    • Amplification
    • Neuroblastoma
  42. proto-oncogene: CCND1 (Cyclin D1)

    what activation and tumor?
    • Translocation: Mantle cell lymphoma, multiple myeloma
    • Amplification: Breast and esophageal cancers
  43. proto-oncogene: CDK4

    what activation and tumor?
    • Amplification or point mutation 
    • Glioblastoma, melanoma, sarcoma
Author
eayilat_alghabat
ID
365799
Card Set
Oncogenes, Mode of Activation, and Associated Human Tumors
Description
Updated