-
growth factor
PDGF-β
what proto-oncogene?
PDGFB
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fibroblast growth factors
what proto-oncogene?
-
growth factor TGF-α
what proto-oncogene?
TGFA
-
growth factor HGF
what proto-oncogene?
HGF
-
EGF receptor family
what proto-oncogene?
-
FMS-like tyrosine kinase 3
what proto-oncogene?
FLT3
-
Receptor for neurotrophic factors
what proto-oncogene?
RET
-
PDGF receptor
what proto-oncogene?
PDGFRB
-
Receptor for KIT ligand
what proto-oncogene?
KIT
-
ALK receptor
what proto-oncogene?
ALK
-
GTP-binding (G) proteins
what proto-oncogene?
-
Nonreceptor tyrosine kinase
what proto-oncogene?
ABL
-
RAS signal transduction
what proto-oncogene?
BRAF
-
Notch signal transduction
what proto-oncogene?
NOTCH1
-
JAK/STAT signal transduction
what proto-oncogene?
JAK2
-
Transcriptional activators
what proto-oncogene?
-
Cyclins
what proto-oncogene?
CCND1
-
cyclin-dependent kinase
what proto-oncogene?
CDK4
-
proto-oncogene: PDGFB
what activation and tumor?
- Overexpression
- Astrocytoma
-
proto-oncogene: HST1
what activation and tumor?
- Overexpression
- Osteosarcoma
-
proto-oncogene: FGF3
what activation and tumor?
- Amplification
- Stomach cancer
- Bladder cancer
- Breast cancer
- Melanoma
-
proto-oncogene: TGFA
what activation and tumor?
- Overexpression
- Astrocytomas
-
proto-oncogene: HGF
what activation and tumor?
- Overexpression
- Hepatocellular carcinoma
- Thyroid cancer
-
proto-oncogene: ERBB1 (EGFR)
what activation and tumor?
- Mutation
- Adenocarcinoma of lung
-
proto-oncogene: ERBB2 (HER)
what activation and tumor?
- Amplification
- Breast cancer
-
proto-oncogene: FLT3
what activation and tumor?
- Point mutation or small duplications
- Leukemia
-
proto-oncogene: RET
what activation and tumor?
- Point mutation
- Multiple endocrine neoplasia 2A and B
- Familial medullary thyroid carcinomas
-
proto-oncogene: PDGFRB
what activation and tumor?
- Amplification, translocation
- Gliomas,
- Leukemias
-
proto-oncogene: KIT
what activation and tumor?
- Point mutation
- Gastrointestinal stromal tumors,
- seminomas,
- leukemias
-
proto-oncogene: ALK
what activation and tumor?
- Translocation: Adenocarcinoma of lung, Lymphomas
- Point mutation: Neuroblastoma
-
proto-oncogene: KRAS
what activation and tumor?
- Point Mutation
- Colon, lung, and pancreatic tumors
-
proto-oncogene: HRAS
what activation and tumor?
- Point Mutation
- bladder and kidney tumors
-
proto-oncogene: NRAS
what activation and tumor?
- Point Mutation
- Melanomas, hematologic malignancies
-
proto-oncogene: GNAQ
what activation and tumor?
- Point mutation
- Uveal melanoma
-
proto-oncogene: GNAS
what activation and tumor?
- Point mutation
- pituitary adenoma, endocrine tumors
-
proto-oncogene: ABL
what activation and tumor?
- Translocation
- Chronic myelogenous leukemia
- Acute lymphoblastic leukemia
-
proto-oncogene: BRAF
what activation and tumor?
- Point mutation
- Melanomas, leukemia, colon carcinoma
-
proto-oncogene: NOTCH1
what activation and tumor?
- Point mutation, translocation
- Leukemias, lymphomas, breast carcinoma
-
proto-oncogene: JAK2
what activation and tumor?
- Point mutation, translocation
- Myeloproliferative disorders
- Acute lymphoblastic leukemia
-
proto-oncogene: MYC
what activation and tumor?
- Translocation
- Burkitt lymphoma
-
proto-oncogene: NMYC
what activation and tumor?
- Amplification
- Neuroblastoma
-
proto-oncogene: CCND1 (Cyclin D1)
what activation and tumor?
- Translocation: Mantle cell lymphoma, multiple myeloma
- Amplification: Breast and esophageal cancers
-
proto-oncogene: CDK4
what activation and tumor?
- Amplification or point mutation
- Glioblastoma, melanoma, sarcoma
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