Well-defirentiated cells resemble normal cells of the tissue from which the tumor originated.
Benign
Cells are undifferentiated and may bear little resemblance to the normal cells of the tissue from which they arose.
Malignant
Tumor grows by expansion and does not infiltrate the surrounding tissues; usually encapsulated.
Benign
Grows at the periphery and overcomes contact inhibition to invade and infiltrate surrounding tissues.
Malignant
Rate of growth is usually slow.
Benign
Rate of growth variable and depends on the level of differentiation; the more anaplastic the tumor, the faster its growth.
Malignant
Does not spread by metastasis.
Benign
Gains access to the blood and lymphatic channels and metastasize to other areas of the body or grows across body cavities such as the peritoneum.
Malignant
Usually localized phenomenon that does not cause generalized effects unless its location interferes with vital functions.
Benign
Often causes generalized effects, such as anemia, weakness, systemic inflammation, weight loss and CACS.
Malignant
Does not usually cause tissue damage unless its location interferes with blood flow.
Benign
Often causes extensive tissue damage as the tumor outgrows its blood supply or encroaches on blood flow to the area; may also produce substances that cause cell damage.
Malignant
Does not usually cause death unless its location interferes with vital functions.
Benign
Eventually causes death unless growth can be controlled.