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Match the disease or use to the correct drug - abacavir (ABC).
NRTI HIV drug developed at University of Minnesota.
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Match the disease or use to the correct drug - amprenavir (AMP).
PI HIV drug. Most often used in combination with ritonavir.
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Match the disease or use to the correct drug - fosamprenavir (Lexiva, FAMP).
PI HIV drug. Prodrug of amprenavir with increased F. Contains sulfonamide. Check contraindications.
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Match the disease or use to the correct drug - atazanavir (ATV).
- PI HIV drug.
- Preferred in patients with elevated cholesterol or atherosclerosis and glucose intolerance.
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Match the disease or use to the correct drug - efavirenz (EFV).
- NNRTI HIV Drug.
- EFV + TDF + FTC (Atripla) is first-line option and most commonly used combination.
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Match the disease or use to the correct drug - emtricitabine (emtriva-FTC).
- NRTI HIV drug.
- Used only in combination with AZT.
- Also approved for treatment of chronic Hep B.
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Match the disease or use to the correct drug - enfuvirtide (Fuzeon).
- Entry inhibitor HIV drug.
- Salvage therapy.
- Will be used in combo with HAART therapy
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Match the disease or use to the correct drug - etravirine (Intelence, ETV).
- The newest NNRTI for HIV.
- Used only in combo with nucleoside analogs in patients harboring NNRTI resistant virus.
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Match the disease or use to the correct drug - fosamprenavir (FAMP).
PI HIV drug.
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Match the disease or use to the correct drug - lamivudine (3TC).
- NRTI HIV drug.
- Also approved for treatment of chronic Hep B.
- cytidine analog, 5'-triphosphate metabolite is the active drug.
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Match the disease or use to the correct drug - lopinavir/ritonavir (LOP).
PI HIV drug.
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Match the disease or use to the correct drug - mariviroc (Selzentry, MVC).
Entry inhibitor HIV drug.
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Match the disease or use to the correct drug - nelfinavir (NFV).
PI HIV drug.
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Match the disease or use to the correct drug - nevirapine (NVP).
- NNRTI HIV drug.
- Only use in combo with nucleoside analogs.
- More adverse events than with efavirenz.
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Match the disease or use to the correct drug - raltegravir.
- Integrase inhibitor HIV drug.
- raltegravir + TDF/FTC (truvada) is now recommended (2010) as a first line combination due to low potential for drug-drug interactions, low toxicity and minimal effects on lipids.
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Match the disease or use to the correct drug - ritonavir (RTV).
PI HIV drug.
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Match the disease or use to the correct drug - saquinavir (SQV HGC or SGC)
PI HIV drug.
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Match the disease or use to the correct drug - stavudine (d4t)
- NRTI HIV drug.
- not used very often.
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Match the disease or use to the correct drug - tenofovir DF (TDF).
- NtRTI HIV drug.
- Will be FDA approved soon for treatment of HepB.
- TDF + FTC (tuvada) is one of the recommended initial therapy backbones for HIV patients also infected with HepB.
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Match the disease or use to the correct drug - tipranavir (TPV)
PI HIV drug.
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Match the disease or use to the correct drug - zidovudine (Retrovir also in Combivir and Trizivir, AZT or ZDV)
- NRTI HIV drug.
- First line for prevention of maternal-fetal HIV transmission.
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Match the disease or use to the correct drug - Acyclovir (ACV).
- Nucleoside anti-herpes agent.
- guanosine analog.
- Treatment and amelioration of Herpes virus infections (outbreaks).
- It can be used topically on lesions or systemically.
- not active against latent forms of the virus and thus is not a cure
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Example of activating a nucleoside prodrug to the active nucleotide - acyclovir (ACV).
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Match the disease or use to the correct drug -Valacyclovir (VZV).
- Herpes Virus Infection: HSV-2 and HSV1 (cold sores)
- Varicella Zoster Virus Infections (Shingles): NOT chicken pox.
- Unapproved uses: HIV suppression and Epstein-Barr Virus Infection
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Match the disease or use to the correct drug -Famciclovir & Penciclovir.
- Nucleoside Anti-Herpes drugs.
- Famciclovir is prodrug for and is better absorbed than penciclovir.
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Match the disease or use to the correct drug - Ganciclovir.
- Nucleoside CMV drug that inhibits the activity of the viral DNA polymerase.
- Uses: CMV prophalaxis in AIDS patients, orally in oran transplant, burkitt's lymphoma, HHV-6 encephalitis and hepatitis, topical gel for herpetic keartitis.
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Match the disease or use to the correct drug - Cidofovir.
- Nucleotide analog that mimics the structure of cytidine
- monophosphate.
- Uses: severe cytomegalovirus (CMV) infections; broad activity vs all HHV, HPV, adeno virus and pox virus.
- Use is limited due to toxicity.
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Match the disease or use to the correct drug - Foscarnet.
- Organic analog of inorganic pyrophosphate.
- Treatment of severe CMV.
- Treatment of acyclovir-resistant HSV.
- HHV-6 and CMV infections.
- IV only
- nephrotoxic
- causes seizures
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Match the disease or use to the correct drug - Imiquimod.
- activates immune cells by binding to toll-like receptor 7 (TLR7)
- Genital warts
- Skin cancers
- Actinic keratosis
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Match the disease or use to the correct drug - Adefovir.
- ANTI-HEPATITIS B REVERSE TRANSCRIPTASE INHIBITORS: Adenosine monophosphate analog
- approved only for HBV
Hepatitis B: may be useful in cases where there is lamivudine resistance.
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Match the disease or use to the correct drug - Entecavir
- ANTI-HEPATITIS B REVERSE TRANSCRIPTASE INHIBITOR
- guanasine analog
- contraindicated in pregnancy
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Match the disease or use to the correct drug - Telbivudine
- ANTI-HEPATITIS B REVERSE TRANSCRIPTASE INHIBITORS
- thymadine analog
- ok to use in pregnancy
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Match the disease or use to the correct drug - Ribavirin
- Hep C - main use
- RSV
- influeza virus and and B (unlabled use)
- HSV
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Match the disease or use to the correct drug - Pegylated interferon a-2B
current preferred treatment for Hep C
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A typical first-line therapeutic regimen for HIV.
- HAART- usually consists of two nucleosides plus either a NNRTI or a PI combo (with RTV)
- Example 1: Truvada (TDF/FTC) + Sustiva (EFV)
- Example 2: Truvada (TDF/FTC) + Kaletra (lopinavir/RTV)
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A typical first-line therapeutic regimen for Hep B.
- Lamivudine (3TC): it has a better side effect profile and less interactions than entecavir, telbivudine and adefovir
- may need to switch to adefovir if resistance developes
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A typical first-line therapeutic regimen for Herpes infections.
valcyclovir?
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A typical first-line therapeutic regimen for influenza.
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