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Action:
- stops the reabsorption of sodium and chloride in the proximal tubule and loop of Henley
- decreases cardiac preload by increasing venous capacitance
- causes quick diuresis
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Indication.
Pulmonary edema secondary to CHF, hepatic adrenal diseases
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Contraindications
- hypersensitivity to drug,
- hypovolemia
- dehydration
- severe electrolyte depletion (hypokalemia)
- hypersensitivity to sulfonamides
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Precautions
- protect from light
- don’t use if solution is yellow ordiscolored
- furosemide has been known to cause fetal abnormalities, dehydration, positional hypotension
- Digitalis toxicity may be increased due to potassium depletion
- Lithium toxicity may be increased due to sodium depletion
- May increase therapeutic effects of antihypertensive drugs
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Side effects
- hypotension
- dry mouth
- hypochloremia
- hypokalemia
- hyponatremia,
- hypercalcemi
- hyperglycemia
- and ECG change secondary to electrolyte disturbances
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Dose
Route
- Adult: 20 to 40mg (0.2-1.0mg/kg) slow IV over 1-2minutes (not to exceed 20mg/minute)
- Pedi: 1mg/kg (max 6mg/kg total dose)
IV
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Onset
Duration
diuretic effects within 15-20 minutes, vascular effects within 5 minutes
2 hours
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