(midsagittal plane divides brain into equal halves)
What is dura mater?
A thick and tough meninx in the CNS
What is pia mater?
meninx in the CNS attached to brain and spinal cord, contains small surface blood vessels
What is the arachnoid membrane?
soft and spongy meninx in the CNS; named for spider-like trabeculae
What is the subarachnoid space filled with?
CSF
The PNS is covered by what?
Dura and pia mater -fused to form sheath
What is apoptosis?
overproduction of neurons (by more than 50%)
What happens to dendritic branch density throughout development?
Pruning takes place
It peaks at age 1-2 (?) and drops through age 16 (then levels off)
–2006 NIMH imaging study finds density peaks at age 11 (girls) and 12 (boys) and then drops
–2016 Imaging—weight peaks 3rd to 4th decade
What are ventricles?
Hollow, interconnected chambers
What does the third ventricle connect with?
Third ventricle connects to cerebral aqueduct to fourth ventricle near cerebellum
What does the third ventricle do?
divides brain into equal halves, massa intermedia crosses the middle
What are the largest ventricles?
lateral ventricles
What is CSF manufactured by?
choroid plexus
What is a circuit?
The collective noun for ‘brain region’
–Any two or more regions can be described as a ‘circuit’
Synonyms: network, matrix, pathway
What is the telencephalon?
"end brain"
part of the forebrain
includes the cortex, basil ganglia, hippocampus, and amygdala
What are the four lobes of the brain?
frontal, parietal, temporal, and occipital
What is the cortex made up of?
glia, cell bodies, dendrites & axons
What are glia?
supportive and nourishing cells
is cortical tissue mylelinated?
No, it is unmylenated (gray matter)
subcortical tissue is mylinated (white matter)
What is myelin made up of?
80% lipids, 20% protein
What is the prefrontal cortex responsible for?
Formulating plans and strategies
What are mirror neurons?
a class of neuron that modulate their activity both when an individual executes a specific motor act and when they observe the same or similar act performed by another individual.
Found in the frontal, parietal regions, somatosensory cortex and more
Are the limbic system and basal ganglia subcortical regions?
Yes
What is lateralization?
refers to a functional dominance of one hemisphere over the other, in which one is more responsible or entirely responsible for control of a function in comparison to the other.
What is the left hemisphere of the brain responsible for?
analysis of information, controlling serial behaviors
–Language, communication, writing, and speech Interpretation and production of symbolic information (e.g. language, mathematics, abstraction and reasoning)
What is the right hemisphere of the brain responsible for?
–Processing multi-sensory input simultaneously to provide ‘holistic’ picture of environment
What does the corpus callosum do?
connects the two hemispheres of the brain
What is the limbic system responsible for?
Regulation of emotion and motivation, also learning and memory
What does the limbic system include?
cingulate cortex, hippocampus (seahorse) and amygdala (almond) adjacent to lateral ventricles in temporal lobes
What is the basal ganglia and what three things does it include?
The basal ganglia is a collection of nuclei (neurons) beneath anterior portions of lateral ventricles; Involved in motor control
includes caudate nucleus, putamen, and globus pallidus
What is the thalamus?
Relay station for all senses except olfaction; controls general excitability of cortex
What is the hypothalamus?
A part of the brain located under the thalamus that controls the autonomic NS and endocrine system and organizes behaviors related to survival (temperature regulation/heat gain)
What is the pituitary gland?
a part of the brain connected to the base of the hypothalamus via the pituitary stalk
Posterior pituitary gland: Oxytocin and vasopressin
What is the tectum?
Part of the midbrain
tectum = roof
Part of auditory system and controls visual reflexes
What is the tegmentum?
part of the midbrain
tegmentum = covering
includes the reticular formation that is responsible for arousal and attention
What is periaqueductal gray matter (PAG) responsible for?
fighting and mating
What are the raphe nuclei responsible for?
releasing serotonin to the rest of the brain?
What is the substantia nigra responsible for?
production of dopamine
What is the cerebellum responsible for?
The cerebellum is the "little brain" and is responsible for coordinating motor movements and is involved in learning
What is the pons responsible for?
Pons is the "bridge" and is involved in refining musclar activity and enabling communication between the cerebellum and the cerebrum
What is the medulla oblongata responsible for?
It contains part of the reticular formation (nuclei that control vital functions) and is involved in HR, respiration, vasomotor control, swallowing, vomiting, sneezing & coughing
What is the enteric nervous system (ENS) or Intrinsic nervous system?
The enteric nervous system (ENS) is the intrinsic nervous system of the gut, made up of an extensive network of neurons that lines the walls of the gastrointestinal (GI) tract.
Known as "another brain"
The spinal cord is made up of how many vertebrae?
31
–Cervical=8 (atlas and axis)
–Thoracic=12
–Lumbar=5
–Sacral=5
–Coccygeal=1
What are spinal nerves?
Part of the PNS that brings sensory info to brain
What are afferent pathways? What are efferent pathways?
Afferent pathways are sensory pathways (A to the brain)
Efferent pathways are motor pathways (from brain to body)
what is the mnemonic for cranial nerves?
some say marry money but my brother says big brains matter most
–S=sensory
–M=motor
–B=both
What is the fifth cranial nerve?
The trigeminal nerve
What is the tenth cranial nerve?
The vagus nerve–Controls organs in thoracic and abdominal cavities
What is the somatic nervous system?
The Voluntary nervous system; Receives sensory information and controls movement
What is the autonomic nervous system?
Involuntary nervous system that controls involuntary physiologic processes including heart rate, blood pressure, respiration, digestion, and sexual arousal
What is the sympathetic nervous system?
a part of the nervous system that controls the flight or fight response
What is the parasympathetic nervous system?
a part of the nervous system responsible for the body's rest and digestion response when the body is relaxed, resting, or feeding.
What are neurons?
nerve cells that send messages all over your body to allow you to do everything from breathing to talking, eating, walking, and thinking
–Oldest and longest cells in the body
What are sensory neurons?
nerve cells that are activated by sensory input from the environment
What are motor neurons?
nerve cells responsible for carrying signals away from the central nervous system towards muscles to cause movement. They release neurotransmitters to trigger responses leading to muscle movement.
What are interneurons?
nerve cells that connect sensory neurons and motor neurons
What is the soma?
cell body/nucleus
What are dendrites?
Branches that “commune” with other neurons via synapse; the receiving end of neurons
What is an axon?
A long slender tube often covered by myelin sheath that carries information away from cell body
What are multipolar neurons?
a type of neuron that possesses a single axon and many dendrites (and dendritic branches)
What is a bipolar neuron?
a type of neuron characterized by having both an axon and a dendrite extending from the soma (cell body) in opposite directions.
What is a unipolar neuron?
a neuron that only has one nerve process extending from the cell body: an axon that extends into dendrites.
What are terminal buttons?
found at the end of the axon, below the myelin sheath, and are responsible for sending the signal on to other neurons.
What is the membrane of a neuron?
A double layer of lipid molecules
What do proteins do?
Detect other substances and control access to interior (transport in and out of cell)
What do enzymes do?
Control chemical actions (“marriages & divorces”)
What is unique about mitochondria?
They contain their own DNA
(they also make ATP)
What are glia cells?
glia = glue
a type of cell that provides physical and chemical support to neurons and maintain their environment
What are the three types of glial cells?
astrocytes, oligodendrocytes, and microglia
(There also are NG2 cells)
What are astrocytes responsible for?
Support, nourish, monitor and address critical chemical levels and clean up/recycling
Phagocytosis
Receive glucose from capillaries, reduce to lactate, pass to neurons
Interfere with neuronal recovery
What are oligodendrocytes responsible for?
allow the fast and efficient transfer of neuronal communication through the myelination of axons
True or false: oligdendrocytes are the myelin sheath
True
What are nodes of rainvier?
Nodes of Ranvier are gaps in the myelin sheath coating on the neural axon. The myelin allows the electrical impulse to move quickly down the axon. The nodes of Ranvier allow for ions to diffuse in and out of the neuron, propagating the electrical signal down the axon
What are schwann cells?
Schwann cells are a type of glial cells of the peripheral nervous system that help form the myelin sheath around the nerve fibers
–Framework for dendritic growth & repair
What are microglia?
a type of glia responsible for immune and inflammatory responses
What are NG2 cells?
A new-ish category of macroglia that transform not only into different kinds of glia, such as oligodendrocytes and astrocytes, but also into neurons
What is the blood-brain barrier?
a selective semi-permeable membrane between the blood and the interstitium of the brain allowing cerebral blood vessels to regulate molecule and ion movement between the blood and the brain.
Walls of capillaries
–Area Postrema
–BBB blocks all molecules except those that cross by lipid solubility
Oxygen, carbon dioxide, Ethanol, and steroid hormones, vitamins A, D, E & K, THC
Or allowed in by specific transport systems
–Sugars & some amino acids
What is the voltage inside a cell membrane?
-70mV
What is depolarization?
Taking away some of the electrical charge and reducing membrane potential
What is the threshold of excitation?
the minimum level of depolarization required for an action potential to occur in nerve and muscle cells.
-55mV
What is an action potential?
a rapid sequence of changes in the voltage across a membrane
2msec
What happens to particle movement with depolarization?
Depolarization
Inside becomes more positive/less negative relative to resting state
What happens to particle movement with hyperpolarization?
More negative than resting potential for nanosecond
What is diffusion?
the force on molecules to move from areas of high concentration to areas of low concentration.
What is electrostatic pressure?
the force on two ions with similar charge to repel each other and the force of two ions with opposite charge to attract to one another.
What are cations?
positive
What are anions?
negative
What is intracellular fluid and extracellular fluid?
Intracellular fluid (ICF) is the cytosol within the cell. Extracellular fluid (ECF) surrounds the cells serves as a circulating reservoir
-extracellular fluid is the seawater
Organic anions (A-):
Intracellular
Membrane is impermeable (stay inside)
Chloride (CL-):
Predominantly extracellular
Diffusion balances with electrostatic pressure
potassium (K+):
Predominantly intracellular
Diffusion balances with electrostatic pressure
Sodium (Na+):
Predominantly extracellular
Diffusion and electrostatic pressure push it across membrane
Membrane is impermeable to it—or is it?
What does the sodium potassium pump do?
Pumps out sodium as fast as it gets in (but in doing so uses 40% of metabolic resources); trades Na+ for K+
What is the all or none law?
a description of the natural observable phenomenon that a nerve will fire with the same intensity regardless of the starting impulse.
What is the rate law?
the more intense a stimulus is, the faster the neuron will fire.