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DO2
- delivery of oxygen to tissue
- DO2 = CO x CaO2
CaO2

O2 content in arterial blood
CO equation

HR x SV
CaO2 equation

Hb PaO2 SaO2
SV factors
- preload
- contractility
- afterload
Determinants of MAP
- Co x SVR
- SVR = systemic vascular resistance
Dexdomitor effects
- Increases parasympathetic tone = decreased HR
- Decreased sympathetic tone = decreased contractility
- Vasoconstriction = Decreased overall perfusion and myocardial perfusion
Zen Alpha
- Medetomidine - alpha 2
- Vatinoxan - peripheral alpha 2 antagonist
Dexmedetomidine

Alpha 2 agonist
Zen Alpha effects
- Increased parasympathetic tone = Decreased HR
- Decreases in sympathetic tone = decreased contractility
- Vasonconstriction - decreased overall perfusion and myocardial perfusion
Vatinoxan = decrease in all above effects
PaO2 of arterial blood gas at sea level and Boulder
- 100 mmHg sea level
- 75 mmHg Boulder
PaO2 with dexdomitor at sea level and Boulder
- Sea level = 70 mmHg
- Boulder = 55 mmHg
90% on pulse-ox is equivalent to PaO2 of ______

60 mmHg
Dog alpha-2 protocol
- Dexdomitor 0.005 mg/kg
- Hydromorphone 0.1 mg/kg
- +/- low dose anticholinergic Atropine 0.02 mg/kg
- Zen Alpha dose on medetomidine 0.005 mg/kg
- Hydromorphone 0.1 mg/kg
Dexdomitor cat protocol
- Dexdomitor 0.005 - 0.01 mg/kg
- Hydromorphone 0.1 mg/kg
- Typically NO anticholinergic
Alfaxalone cat premedication
- Alfaxalone 3-5 mg/kg
- +/- hydromorphone 0.1 mg/kg (increases duration)
- +/- midazolam 0.1 mg/kg (increases duration)
- Can combine in 1 syringe

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Anesthesia bootcamp

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2023-12-14T14:56:29Z