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Dendrites
extensions from the soma which receive input from other neurons; contain dendritic spines
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Cell Body (soma)
determines whether an action potential will occur; contains nucleus
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Axon hillock
decision center; decided to/not to send action potentials
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Axon
conducts the action potential; how we communicate over long distances
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Axon terminals
located at the end of an axon; contain synaptic vesicles with neurotransmitters for chemical transmission between neurons
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Synapse
where two neurons "meet"; neurons form synapses with each other, and neurotransmitters are relayed from one neuron to another at the synapse
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Nodes of Ranvier
places where the myelin sheath does not cover
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Myelin (definition, formation, function)
fatty protein that insulates the axon; produced by glial cells (oligodendrocytes in the central system, Schwann cells in the peripheral nervous system); insulates axons, speeds up action potential transmission
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Action Potential
electrical signal along the neuron; causes release of neurotransmitters; the movement of ions into and out of the axon; begins at the axon hillock and ends at the axon terminal
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Depolarization/Hyperpolarization
- Depolarization: moving from resting potential to threshold (less negative)
- Hyperpolarization: make more negative (opposite)
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Ion movement
sodium (Na+) ions move in and potassium (K+) ions move out during an action potential.
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Myelinated axon
action potential regenerated at nodes of Ranvier
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Refractory Period
- Absolute
- Relative
- Absolute: sodium channels cannot be opened, axon membrane cannot trigger a new action potential.
- Relative: axon membrane only responds to stimulation that is higher than what initiated the action potential (occurs after absolute refractory period).
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Conduction velocity
determined by axon diameter (wider is faster) and myelination (more myelination is faster
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Synapse Structure
- components (5)
- terminal
- vesicles
- transporters
- dendrite/spine
- neurotransmitter receptors
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Presynaptic terminal
contains vesicles with NT inside, transports
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Postsynaptic terminal
dendrite (spine), NT receptors
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Synaptic process
NTs released into the synapse, bind to receptors on the postsynaptic membrane
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EPSPs
excitatory postsynaptic potentials depolarize the membrane; influence the postsynaptic cell to generate an AP; NT binds to receptor in postsynaptic membrane, positive ions (Na+) move into the postsynaptic cell, and local voltage changes in postsynaptic cell.
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IPSPs
inhibitory postsynaptic potentials hyperpolarize the membrane; Deinfluence the postsynaptic cell to generate an AP; NT binds to receptor in postsynaptic membrane, negative ions (Cl-) move into the postsynaptic cell, and local voltage changes in postsynaptic cell.
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Cortex
- lobes
- frontal, parietal, temporal, occipital
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Cortex
- major fissures (areas)
- central sulcus - separates frontal from parietal lobes
- lateral fissure - separates frontal and parietal from temporal lobes
- longitudinal fissure - separates the hemispheres
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Primary cortices of the lobes
- Frontal lobe: primary motor cortex, prefrontal cortex
- Parietal lobe: primary somatosensory cortex (S1)
- Temporal lobe: primary auditory cortex
- Occipital lobe: primary visual cortex
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Processing sides
generally contralateral processing (e.g. left hemisphere controls the right side of the body)
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Prefrontal cortex
located at the front; involved in decision-making, personality, and social behavior
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Visual processing streams
- "what" stream (ventral): object recognition
- "where" stream (dorsal): spatial location
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What/where are the major language areas?
- Broca's area: frontal lobe; left hemisphere only; language production
- Wernicke's area: temporal lobe; left hemisphere only; language comprehension
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Brainstem
- parts and functions
medulla (vital functions), pons (relay station, involved in REM sleep), midbrain (sensorimotor functions)
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Cerebellum
- functions
coordination, balance, and motor learnings
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Thalamus
- function
sensory relay station/filter
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Hypothalamus: memory formation, consolidation of explicit memories; limbic system
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Amygdala
- emotion processing, particulary fear; limbic system
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Corpus callosum
bundle of axons that connects the two hemispheres of cortex
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pituitary gland
master gland; regulates endocrine system; attached to and regulated by the hypothalamus
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pineal gland
produces and secretes melatonin; regulates sleep-wake cycle, daily and seasonal rhythms
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Limbic system
emotional procesing and memory (e.g. hippocampus and amygdala)
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Basal ganglia
- moto control and procedural learning (Substantia nigra, Caudate, Putamen, Globus pallidus)
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Central nervous system (CNS)
- brain and spinal cord
- - spinal cord exhibits the Bell-Magendie Law: sensory info enters the cord posteriorly; motor info exits cord anteriorly.
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Peripheral nervous system (PNS)
autonomic (involuntary) and somatic (voluntary) branches
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Endocrine system
- Hypothalamic pituitary axes
- adrenal - CRF, ACTH, adrenal cortex-cortisol
- gonadal - GNRH, LH, FSH, estradiol, testosterone, progesterone, DHT
- thyroid - TSH-RH, TSH (T3/T4)
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Endocrine System
- negative feedback
mechanism to maintian hormonal balance; tropic hormone turns itself off by acting at anterior pituitary to inhibit further tropic hormone release and the hypothalamus to inhibit further releasing hormones.
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Neurological Disorders
- Alzheimer's Disease
affects the hippocampus and surrounding areas
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Neurological Disorders
- Parkinson's Disease
involves the basal ganglia
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