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Respiratory System functions
- Regulation of blood pH
- Voice Production
- Olfaction
- Innate Immunity
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Upper respiratory tract
- External nose
- Nasal cavity
- Pharynx
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composed of mainly of hyaline cartilage
External nose
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extends from nares (nostrils) to choane
Nasal cavity
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openings to pharynx
hard palate is its roof
Choana
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• air filled spaces within bone
• open into nasal cavity
• Sinusitis
Paranasal sinuses
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• on each side of nasal cavity
• increase surface area of nasal cavity
• help in cleaning, humidifying, warming of air
Conchae
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• carry tears from eyes
• open into nasal cavity
Nasolacrimal ducts
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a common passageway for the respiratory and digestive systems
Pharynx
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extends from uvula to epiglottis
takes in food, drink, and air
Oropharynx
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• extends from epiglottis to esophagus
• food and drink pass through
Laryngopharynx
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• “little grape”
• extension of soft palate
Uvula
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aids in defending against infections
Pharyngeal tonsil
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Lower Respiratory Tract
- Larynx – lower portions of Trachea
- Bronchi
- Lungs
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Located in the anterior throat and extends from the base of the tongue to the trachea.
Larynx
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cartilages in larynx
Thyroid cartilage and epiglottis
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• largest piece of cartilage
• called Adam’s apple
Thyroid cartilage
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• piece of cartilage
• flap that prevents swallowed materials from entering larynx
Epiglottis
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• source of voice production
•air moves past them, they vibrate, and sound is produced
• force of air determine loudness
• tension determines pitch
Vocal folds/cords
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inflammation of vocal folds
caused by overuse, dry air, infection
Laryngitis
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How does the epiglottis prevent aspiration of foods and liquids?
Ans. During swallowing, the epiglottis closes over the rima glottidis, the entrance to the trachea, to prevent aspiration of food and liquids into the lungs.
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• Windpipe
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Consists of 16 to 20 C-shaped pieces of cartilage
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Contains cilia pseudostratified columnar epi.
• Smoking kills cilia
Trachea
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_________ dislodges materials from trachea
Coughing
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Divides into right and left primary bronchi (lungs)
Trachea
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an operation to make an opening into the trachea.
Tracheostomy
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• Divide from trachea
• Connect to lungs
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Lined with cilia
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Contain C-shaped pieces of cartilage
Bronchi
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• Primary organ of respiration
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Cone shaped
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The base rests on the diaphragm
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The apex extends above the clavicle
• Right lung has 3 lobes
Left lung has 2 lobes
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Contains many air passageways
Lungs
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Lung airway passages
- 1. Primary bronchi
- 2.
Lobar (secondary) bronchi
- 3. Segmental (tertiary) bronchi
- 4. Bronchioles
- 5. Terminal bronchioles
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Respiratory bronchioles
- 7.
Alveolar ducts
- 8.
Alveoli
- Structures become smaller and more
numerous from primary bronchi to alveoli
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• small air sacs
• where gas exchange occurs
• surrounded by capillaries
• 300 million in lungs
Alveoli
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contraction of terminal bronchioles leads to reduced air flow
Asthma attack
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• in lungs where gas exchange between air and blood occurs
• Formed by walls of alveoli and capillaries
• Very thin for diffusion of gases
Respiratory Membrane
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double-layered membrane around lungs
Pleura
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membrane that lines thoracic cavity
Parietal pleura
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membrane that covers lung’s surface
Visceral pleura
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Reminder!
Pleural cavity: with fluid
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• a process of moving air in and out of the lungs
• uses the diaphragm, which is a skeletal muscle that separates the thoracic and abdominal cavities
Ventilation (breathing)
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Phases of ventilation
- Inspiration
- Expiration
- Forceful expiration
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• breathe in
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uses the diaphragm and the external intercostal muscles
Inspiration
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• breathe out
• uses the diaphragm
Expiration
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uses internal intercostal muscles
Forceful expiration
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Right now, what is the main muscle that is powering your breathing?
Diaphragm and External intercostals.
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What muscles involved during exercise of forceful breathing?
Stenocleidomastoid, scalene muscle and pectoralis minor.
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• Diaphragm descends and rib cage expands
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Thoracic cavity volume increases, pressure decreases
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Atmospheric pressure is greater than (high) alveolar pressure (low)
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Air moves into alveoli (lungs)
Inspiration
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• Diaphragm relaxes and rib cage recoils
• Thoracic cavity volume decreases, pressure increases
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Alveolar pressure is greater than (high) atmospheric pressure (low)
• Air moves out of lungs
Expiration
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is the tendency for an expanded lung to decrease in size
Lung recoil
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is due to elastic fibers and thin film of fluid lining alveoli
Lung recoil
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occurs during quiet expiration
Lung recoil
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keeps lungs from collapsing
Surfactant
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is a single fluid layer on the surface of thin fluid lining alveoli thus reduces surface tension
Surfactant
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is produced by secretory cells of the alveoli
Surfactant
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too little surfactant
IRDS(Infant Respiratory Stress syndrome) or Hyaline membrane disease
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drugs for a mother that has little surfactant
Cortisol
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• pressure in the pleural cavity
• less than alveolar pressure
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keep the alveoli from collapsing
Pleural pressure
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intoduction of air into the pleuarl cavity.
Pnemothorax
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Factors that Influence Pulmonary Ventilation
- Lung elasticity
- Lung compliance
- Respiratory passageway resistance
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• lungs need to recoil between ventilations
• decreased by emphysema
Lung elasticity
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• expansion of thoracic cavity
• affected if rib cage is damaged
Lung compliance
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• occurs during an asthma attack, infection, tumor
Respiratory passageway resistance
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Pulmonary volumes
- Functional Residual Capacity(FRC)
- Inspiratory Capacity(IC)
- Vital Capacity (VC)
- Total lung capacity (TLC)
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device that measures pulmonary volumes
Spirometer
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• volume of air inspired and expired during quiet breathing
• 500ml
Tidal volume
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• volume of air that can be inspired forcefully after a normal inspiration
• 3000ml
Inspiratory reserve volume (IRV)
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• volume of air that can be expired forcefully after a normal expiration
• 1100ml
Expiratory reserve volume (ERV)
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• volume of air remaining in lungs after a maximal expiration (can’t be measured with spirometer)
• 1200ml
Residual volume
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amount of air remaining in the lungs at the end of of a normal expiration(2300ml)
? = ERV + RV
Functional Residual Capacity(FRC)
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amount of air a person can inspire maximally after normal expiration (3500ml)
? = TV + IRV
Inspiratory Capacity(IC)
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max. amount of air a person can expire after a max. inspiration(4600ml)
? = IRV + ERV + TV
Vital Capacity (VC)
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sum of inspiratory and expiratory reserves and the tidal and residual volumes (5800)
? = VC + RV
Total Lung Capacity
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Factors that Influence Pulmonary Volumes
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• where gas exchange between blood and air occurs primarily in alveoli and pulmonary capillaries
• some in respiratory bronchioles and alveolar ducts
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does NOT occur in bronchioles, bronchi, trachea(anatomical dead space)
• influenced by thickness of membrane, total area of membrane, partial pressure of gases
Respiratory membrane
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Respiratory membrane thickness
• increased thickness decreases rate of diffusion
• Pulmonary edema decreases diffusion
• Rate of gas exchange is decreased
• O2 exchange is affected before CO2 because CO2 diffuse more easily than O2
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Surface Area
• Decreases surface of respiratory membrane to 1/4 or 1/3 can restict gas exchange.
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Possible reasons are surgical removal of lung tissue.lung cancer, emphysema.
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• the pressure exerted by a specific gas in a mixture of gases
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the total atmospheric pressure of all gases at sea level is 760 mm Hg
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the atmosphere is 21% O2
Partial Pressure
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Partial Pressure
• the partial pressure for O2 is __________
• the upper case letter P represents partial pressure of a certain gas (Po2)
160 mm Hg
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Factors of O2 release from oxyhemoglobin
- 1. Low PO2
- 2. High PCO2
- 3. Low pH
- 4. High temperature
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• Normal respiratory rate is 12 to 20 respirations per minute (adults).
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In children, the rates are higher and may vary from 20 to 40 per minute.
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The rhythm is controlled by neurons in the medulla oblongata.
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Rate is determined by the number of times respiratory muscles are stimulated.
Rhythmic Ventilation
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• inhibits respiratory center when lungs are stretched during inspiration
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touch, thermal and pain receptors in the skin
Hering-Breuer Reflex
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