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[events at cholinergic synapse] what is ach released through
ach is released through the exocytosis of synaptic vesicles
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what does ach bind to
ach bind to sodium channel receptors on the post synaptic membrane
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what does ach produce when it binds to sodium channel receptors
produces a graded depolarisation
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why does depolarisation end
as ach is broken down into acetate and choline by ACHE
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What does the synaptic cleft reabsorb
choline
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what does the synaptic knob use choline for
uses it to synthesis new molecules of Ach
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what happens when the greater amount of Ach is released
this means the greater number of Na channels that will open and the larger the depolarisation
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what is competitive against Ach
NAchR - non-depolarising neuromuscular blocker
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what are other neurotransmitters
- noradrenaline
- dopamine
- serotonin
- GABA
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what is noradrenaline
exicatatory, depolarising, autonomic nervoys system
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what is dopamine
excitatory + inhibitory regulation of motor function
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what is serotonin
CNS, important in emotions and moods
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what is GABA
gamma aminobutyric acid, inhibitory, opens Cl ion channels
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what is parkinsons
damage or destruction of dopamine producing neurons
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what are reflexes
they are rapid, automatic responses to stimuli
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where do reflexes occur
in somatic nerous system, involutary
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