anti infective

  1. Sulfonamide drug names?
    • sulfasalazine(azulfidine)
    • sulfisoxazole (gantrisin)
    • trimethoprim/ sulfamethoxazole (bactrim, septra)
    • silver sulfadiazine (silvadene)
  2. sulfonamide drug action?
    drug indication?
    • UTI, otitis media, ulcerative colitis (azulfidine), sever skin burn (silvadene)
  3. sulfonamide drug adverse reactions?
    and drug interactions?
    skin rash, photosensitivity, ctystalluria, orange urine

    decrease effect of digoxin, oral contraceptives, increase effect of coumadin
  4. sulfonamide NI?
    increase fluid to two L a day to avoid crystalluria, avoid sunlight, take all antibiotic
  5. Natural penicillins?

    semisynthetic PCNs?
    • (made from mold, narrow-spectrum)
    • penicillin G (IM)
    • penicillin V (PO)

    • ampicillin (omnipen) IV, IM
    • amoxicillin (amoxil) IM, IV, PO
  6. penicillin drug action?


    resp infections, syphilis, meningitis, osteomyelitis (bone infect), necrotizing fascitis, prevents endocarditis
  7. penicillin adverse reactions?
    hypersensitivity reactions; hives, itching, wheezing, anaphylactic shock

    superinfections, diarrhea, oral thrush, vaginal infections, hematopoietic changes (decrease cell count)
  8. Pencillin NI?
    Never take with soda of fruit juice

    parenteral PCN may come as a powder and you must dilute, give deep IM to avoid pain
  9. Cephalosporins (broad-spectrum, from fungus, chemically related to PCN) 1st gen ?
    • cephalexin (keflex)
    • cefazolin (ancef, kefzol)

    best against; streptococcus, staphylococcus GM+
  10. 2ond generation cephalosporins?
    • cefaclor (ceclor)
    • cefoxitin (mefoxin)

    Best against; E. coli, klebsiella GM-
  11. cephalosporin 3rd generation?
    • cefoperazone (cefobid)
    • ceftriaxone (rocephin)
    • best against; goncoccus, enerobacter GM-
  12. cephalosporin drug actions and indications?
    • bactericidal
    • treats; skin, bone, and joint infections, ear and resp infections, gonorrhea
  13. cephalosporin drug contraindications?

    adverse reactions?
    if allergy to PCN probably allergic

    hypersensitivity reactions, superinfections, hematopoietic changes, severe skin rash(stevens johnson syndrome)
  14. cephalosprin drug interactions? and NI?
    no alchol, may cause false positive test for urine glucose using clinitest

    give deep IM, take entire antibiotic
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anti infective
anti infective pharmacology