-
Phentoin (Dilantin)
- anticonvulsant-can be used as antidysrhythmic
- monitor levels- should be 10-20 mg/ml
- will increase BS
- EKG- contraindicated in heart block, brady
- Class d pregnancy (okay)
ss: gingival hyperplasia- must continue flossing
toxemia= visual disturbances, slurred speech, lethargy
-
Heparin
- Inhibits fibrin to prevent clots
- IV/SQ
- short term (<21 days)
- measured with aPTT (clotting time <70 secs=ok)
antidote: Protamine sulfate
low molecular weight heparin - long-lasting
- more predictable effect on the body
- Treats DVT
-
Beta Blockers
beta Adrenergic antagonizers
- Blocks B (epi)
- Decreases BP, HR, inotropic, chronotropic, afterload
Indication: arrhythmia, angina, MI, anxiety
-LOL atenelol (tenormin), metoprolol (lopressor)
- Caution: bradycardia <50
- breathing issues (blocks B function)
- CHF
- blood sugar masking
- don't combine with alcohol
- don't combine with CCBs
-
Ca Channel Blockers
↓Ca= ↓contractility (neg inotropic)
- -dipine amlodipine
- -zem diltiazem
- -amil verapamil
indication: HTN, arrhythmia, arterial disease (Raynaud's)
SE: constipation, dizzy, fatigue, cough
- Caution: don't mix with BBs
- No grapefruit
- don't combine with Digoxin
-
ACE inhibitors
-Pril (think A-Pril)
"chills the heart"
- angio-converting enzyme inhibitor
- systemic vasodilation- decreased preload/afterload
May be used with CCBs
indication: HTN, CHF, kidney dysfunction
- SE: Angioedema
- Cough
- Electrolyte imbalance (↑K/proteinuria)
don't mix with ARBs (K retention)
-
ARBs
Angiotensin 2 receptor Blockers
-Tans (relax, get a tan)
indication: HTN, CHF, post-MI, diabetic neuropathy
less SE than ACEs, but not as powerful
Don't mix with ACEs (K retention)
-
STATINs
atorvostatin
lipitor
- Blocks coenyme Q10 C10AA
- lipid-lowering ↓LDL ⇡HDL
- antioxidant
SE: cramps, weakness, memory loss-dementia, anemia, erectile dysfunction
monitor: BUN, Creatinine, Altsa, CK THINK KIDNEYS
-
Coumadin/Warfarin
- Prevents fibrin from growing/forming
- inhibits production of Vit K
- PO
- Long-term therapy (5 day onset)
- 90% protein (should be take with stool softener)
- Lab value= PT/INR (prothrombin time/intn'l value)- should be 2-3 (11-13 seconds)
- Think war-international
antidote: vitamin K (phitonadone)
- Caution: proton-pump inhibitor (increases effects)
- stop 5-7 days prior to sx
- bleeding risk
Can be given along with heparin (short term)
-
Digoxin
Cardiac Glycoside
- Increases CO- +inotropic -chrono -drono
- Check apical pulse for 1 MINUTE prior
- inhibits Na-K pump
- slows SA/AV conduction
- TOXICITY: >2.4
- SS: visual disturbances (halos), N/V, diarrhea, A flutter, H/A, hypokalemia, hypomagnesia
- hypERCalcemia=high risk for Dig tox
- Contraindicated: pregnant
- heart blocks
- milk
- careful with elderly (renal perfusion)
- Don't mix with supplements-St Johns wart, Aloe, Ginsing/golden seal, Ephedra
-
DIURETICS
loop=most powerful (lasix)
-thiazides (most common) rids lots of H2O. can be used long term
K sparing (spirilactone -think"spare-ilactone") Doesn't lower BP as well
Indication: HTN, CHF, kidney problems, liver, glaucoma, edema
- se: hypo K
- hypo Na (cramps)
- HA, dizzy
- increase BS
- Increase cholesterol
- pertussis
- gout
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