(Toxoplasma gondii) ______ are definitive host; excrete organism in feces
Cats
(Toxoplasma gondii) For immunosuppressed patient with focal neurologic signs, ________________ is the most likely diagnosis.
cerebral toxoplasmosis
(Toxoplasma gondii) ____________, the disease of which T. gondii is the
causative agent is usually minor and self-limiting but can have serious or even fatal effects on a fetus whose mother first contracts the disease
during pregnancy or on an immunocompromised human or cat (definitive host).
Toxoplasmosis
(Toxoplasma gondii) Form that is present in cat and other felines but not in humans
Oocyst
(Toxoplasma gondii) shape of oocyst
oval or spherical shape and contains sporoblast
(Toxoplasma gondii) Oocyst is formed by ___________ reproduction
sexual (Gametogony)
(Toxoplasma gondii Morphology) (tachos = speed in Greek) was coined by __________ to describe the stage that rapidly multiplied in any cell of the intermediate host and in nonintestinal epithelial cells of the definitive host.
Frenkel
(Toxoplasma gondii Morphology) The term “___________” replaces the previously used term “trophozoite” (trophicos = feeding in Greek).
tachyzoite
(Toxoplasma gondii) Tachyzoite is _________ shaped
crescent
(Toxoplasma gondii Morphology) these are trophozoites released which infects other cells
Tachyzoite
(Toxoplasma gondii Morphology) occurs in chronic infection; formed when parasites multiply and produce a wall within host cell
Tissue cyst
(Toxoplasma gondii Morphology) __________ are slowly multiplying forms of trophozoite contained in a tissue cyst
Bradyzoites
(Toxoplasma gondii) Serologic prevalence data indicate that _____________ is one of the most common of human infections throughout the world.
toxoplasmosis
(Toxoplasma gondii) T. gondii is important because virtually all warm-blooded animals, including man, can become infected with it. True or False?
True
(Toxoplasma gondii) Cats have a 20% to 40% infection rate with T. gondii. True or False?
False.
20% to 60%
(Toxoplasma gondii) In an older cat, a recurrent infection may be due to the presence of ________________ or feline immunodeficiency virus, which suppress its immune response.
feline leukemia virus
(Toxoplasma gondii) Mostly asymptomatic infection, but new infection in pregnancy causes _________________; also infection in immuno-suppressed.
fetal malformations
(Toxoplasma gondii) Transmission
By poorly cooked meat, from cat stool, rarely water
(Toxoplasma gondii) Detection
Serology
(Toxoplasma gondii) symptoms
-anorexia, weight loss, lethargy, difficulty breathing (because of pneumonia), eye inflammation, and fever
-vomiting and diarrhea, neurological symptoms, swollen lymph nodes,
and jaundice.
(Toxoplasma gondii) Contact with a pet cat or a neighbor's cat will not
increase the risk of acquiring toxoplasmosis, unless these animals are allowed to roam and hunt or eat raw meat. However, contact with stray
and feral cats can be risky. True or False?
True
(Toxoplasma gondii) T. gondii infections have the ability to change the
behavior of rats and mice, making them drawn to, rather than fearful of, the scent of cats. True or False?
True
(Toxoplasmosis) Infected women were more likely to become more
outgoing and showed signs of higher intelligence, while men became aggressive, jealous and suspicious. True or False?
True
(Toxoplasmosis Diagnosis) Specimen
1. Lymph node biopsy
2. Bone marrow aspiration
3. CSF
4. Broncho alveolar lavage
5. Peritoneal fluid
(Toxoplasmosis Diagnosis) Lab procedures
1. Direct microscopy (Leishman/Giemsa Stain) - Findings: Tachyzoite
2. Culture (Bradyzoite is observed)
(Toxoplasmosis Diagnosis) _______________ may indicate recent infection with T. gondii, but not a definitive diagnosis of toxoplasmosis.
Blood serology tests
(Toxoplasmosis) Treatment
-Triple Therapy
-Sulfadiazine / Pyrimethamine / Corticosteroids
(Toxoplasma gondii) The most notable manifestation of toxoplasmosis in
immunocompromised patients is _________________, which can be deadly.
toxoplasmic encephalitis
(Toxoplasma gondii) If infection with T. gondii occurs for the first time
during pregnancy, the parasite can cross the placenta, possibly leading to hydrocephalus or microcephaly, intracranial calcification, and chorioretinitis, with the possibility of spontaneous abortion (miscarriage) or intrauterine death.