The ability of muscle to shorten forcefully, or
contract
Contractility
A type of muscle that is attached to bones, striated, and voluntarily controlled.
Skeletal
A type of muscle that is located in the heart, striated, and involuntarily controlled
Cardiac
A type of muscle that is located in blood vessels,
hollow organs, non-striated, and involuntarily controlled
Smooth
The capacity of muscle to respond to a stimulus
Excitability
The ability to be stretched beyond it normal
resting length and still be able to contract
Extensibility
The ability of the muscle to recoil to its original
resting length after it has been stretched
Elasticity
Skeletal muscle, or striated muscle, with its associated
connective tissue, constitutes approximately how many percent of body weight?
40%
Skeletal muscle is so named because many of the
muscles are attached to the _____ system.
skeletal; skeletal system
True or False? Some skeletal muscles attach to the skin or connective tissue sheets
True
Skeletal muscle is also called _____ muscle because
transverse bands, or striations, can be seen in the
muscle under the microscope.
striated
Individual skeletal muscles, such as the biceps brachii,
are complete _____ , as a result of being comprised of
several tissues: muscle, nerve, and connective tissue.
organs
Each skeletal muscle is surrounded by a connective tissue sheath called ____.
epimysium
A skeletal muscle is subdivided into groups of muscle cells, termed ____.
fascicles
Each fascicle is surrounded by a connective tissue covering, termed _____.
perimysium
Each skeletal muscle cell (fiber) is surrounded by a connective tissue covering, termed _____.
endomysium
A _____ is a large cell, with several hundred nuclei located at its periphery.
muscle fiber
Muscle fibers range in length ____ to ____.
1 mm to 30 cm
Alternating light and dark bands give muscle fibers a _____.
striated appearance
True or False? The number of muscle fibers do not remain constant after birth so enlargement of muscles results from an increase in the size of muscle fibers and also an increase in fiber number.
False,
The number of muscle fibers remains constant after birth so
enlargement of muscles results from an increase in the size of
muscle fibers, not an increase in fiber number.
The sarcolemma (cell membrane) has many tubelike inward folds, called ____.
transverse tubules, or T tubules
The T tubules are associated with enlarged portions of the smooth endoplasmic reticulum called the _____.
sarcoplasmic reticulum
Basically the enlarged portions of the sarcoplasmic reticulum (SR),
terminal cisternae
Two terminal cisternae and their associated T tubule form a ____.
muscle triad
The sarcoplasmic reticulum has a relatively high concentration of
Ca2+, which plays a major role in ______.
muscle contraction
The cytoplasm of a muscle fiber is called the _____, which
contains many bundles of protein filaments.
sarcoplasm
These are bundles of protein filaments
myofibrils
Myofibrils consist of two types of myofilaments; These are?
actin (thin filaments) and myosin (thick filaments)
Actin and myosin are arranged into repeating units called?
sarcomeres
These are are networks of protein fibers that serve as an anchor for actin myofilaments, and separate one sarcomere from the
next.
Z disks
The myofilaments slide past each other, causing the sarcomeres to ____ .
shorten
True or False? Each sarcomere consists of two dark-staining bands separated by a light-staining band.
False
Each sarcomere consists of two light-staining bands separated by a dark-staining band.
Light bands, consist only of actin, and are called ____ . They extend from the Z disc, toward the center of the sarcomere, to the ends of the myosin myofilaments.
I bands
Dark staining bands are called _____ . They extend the length of the myosin myofilaments.
A bands
Actin and myosin myofilaments overlap for some distance on both ends of the A band; this overlap causes the _____.
contraction
Actin myofilaments are made up of three components: _____, _____ and ____.
actin, troponin, and tropomyosin.
____ molecules have binding sites for Ca2+
Troponin
_____ filaments block the myosin myofilament binding sites on the actin myofilaments.
tropomyosin
______ or thick myofilaments, resemble bundles of tiny golf clubs.
Myosin myofilaments
Myosin heads have ATP binding sites, ATPase and attachment spots for ____.
actin
It is a nerve cell that stimulates muscle cells.
motor neuron
It is a synapse where a neuron connects with a muscle fiber
neuromuscular junction
It refers to the cell-to-cell junction between a nerve cell
and either another nerve cell or an effector cell, such as in a muscle or a gland.
synapse
It is a group of muscle fibers that a single motor neuron stimulates.
motor unit
It is the end of a neuron cell axon fiber
presynaptic terminal
It is the space between the presynaptic terminal and
postsynaptic membrane.
synaptic cleft
It is the muscle fiber membrane (sarcolemma).
postsynaptic membrane
It is a vesicle in the presynaptic terminal that stores and
releases neurotransmitter chemicals.
synaptic vesicle
These are chemicals that stimulate or inhibit postsynaptic
cells
Neurotransmitters
It is the neurotransmitter that stimulates skeletal muscles
Acetylcholine
When a muscle contracts, the actin and myosin myofilaments in thesarcomere slide past one another and shorten the ____ .
sarcomere
True or False? When sarcomeres shorten, myofibrils, muscle fibers, muscle fascicles, and muscles all shorten to produce muscle relaxation.
False,
When sarcomeres shorten, myofibrils, muscle fibers, muscle fascicles, and muscles all shorten to produce muscle contraction.
True or False? During muscle relaxation, sarcomeres lengthen.
True
Muscle fibers are ____ excitable.
electrically
Electrically excitable cells are _____.
polarized
In Excitability of Muscle Fibers, the inside of the cell membrane is ____ charged compared with the outside.
negatively; negatively charged
A ______ , or electrical charge difference, exists across each
cell membrane.
voltage difference
The charge difference is due to differences in concentrations of ions on either side of the membrane of an unstimulated cell is called?
resting membrane potential
The phospholipid bilayer is impermeable to ___ .
ions
Two types of membrane proteins, called ____ , permit ions to pass through the membrane.
ion channels
____ allow the slow leak of ions down their concentration gradient.
Leak channels
____ may open or close in response to various types of stimuli.
Gated channels
The electrical charge difference across the cell membrane of an
unstimulated cell is called the _____ .
resting membrane potential
_____ have a resting membrane potential but can also perform action potentials.
Muscle cells (fibers)
These are due to the membrane having gated channels
Action potentials
The ____ of ions through these channels changes the charge
across the cell membrane and produces an action potential.
diffusion
Action potential lasts for ____ to ______.
1 to 3 milliseconds
The entry of Na+ causes the inside of the cell membrane to become more ____ than when the cell is at resting membrane potential.
positive
It is the increase in positive charge inside the cell membrane
depolarization
If the depolarization changes the membrane potential to a value
called _____, an action potential is triggered.
threshold
______ is a rapid change in charge across the cell
membrane
action potential
Opening of gated K+ channels starts ____ of the cell
membrane.
repolarization
In muscle contraction, an action potential travels down the motor neuron to the _____ .
presynaptic terminal
The mechanical component of muscle contraction is called
______.
cross-bridge cycling
True or false? The energy from one ATP molecule is required for one cross bridge cycle.
True
It is the movement of the myosin heads
power strokes
Energy for muscle contractions is supplied by ____.
ATP
____ will occur when a person dies and no ATP is available
to release cross-bridges.
Rigor mortis
Muscle relaxation occurs when ___ is no longer released at the neuromuscular junction.
acetylcholine
In muscle relaxation, the cross-bridge cycle stops and the muscle ____.
relaxes
It is a single contraction of a muscle fiber in response
to a stimulus.
muscle twitch
A muscle twitch has three phases. What are these?
latent phase, contraction phase, and relaxation phase
____ is the time between the application of a stimulus
and the beginning of contraction.
latent phase
____ is the time during which the muscle contracts.
contraction phase
It is the time during which the muscle relaxes.
relaxation phase
There are two types of muscle contractions:
isometric and isotonic
The ____ has an increase in muscle tension, but no change in length.
isometric contraction
It increases the tension in a muscle and decreases the length.
isotonic contraction
It is the amount of force in an individual muscle fiber.
summation
It is the amount of force in a whole muscle.
recruitment
It consists of a single motor neuron and all the muscle
fibers it innervates.
motor unit
True or false?
Small, delicate muscles have very few fibers per motor unit.
Large, powerful, less precise muscles have fewer, larger motor units.
True
Individual muscle fibers can generate different amounts of ____.
force
The amount of force generated depends upon the number of
_____ formed.
cross-bridges
One factor that influences the number of cross-bridges formed is the frequency of _____.
stimulation
______ occurs when the frequency of stimulation only allows for
partial relaxation of the muscle fiber.
Incomplete Tetanus
It is a sustained contraction that occurs when the frequency of
stimulation is so rapid that no relaxation occurs.
Tetanus
It is the stimulation of several motor units.
Recruitment
It is the constant tension produced by body muscles over long periods of time.
Muscle tone
_______ are isotonic contractions in which muscle
tension increases as the muscle shortens.
Concentric contractions
______ are isotonic contractions in which tension is
maintained in a muscle, but the opposing resistance causes the
muscle to lengthen.
Eccentric contractions
It is a type of skeletal muscle fiber that has the following characteristics;
• contract slowly
• fatigue slowly
• have a considerable amount of myoglobin
• use aerobic respiration
• are dark in color
• used by long distance runners
Slow twitch fibers
It is a type of skeletal muscle fiber that has the following characteristics;
• contract quickly
• fatigue quickly
• use anaerobic respiration
• energy from glycogen
• light color
• used by sprinters
Fast twitch fibers
True or False?
The large postural muscles of the back and lower limbs
contain more fast-twitch muscle fibers.
The muscles of the upper limbs contain more slow-twitch fibers.
False,
The large postural muscles of the back and lower limbs
contain more slow-twitch fibers.
The muscles of the upper limbs contain more fast-twitch
muscle fibers.
Muscle fibers have three ATP dependent proteins;
✔ The myosin head
✔ The Na+/K+ ATPase to maintain resting membrane potential
✔ The Ca2+ pump in the sarcoplasmic reticulum
Muscle fibers store enough ATP to contract for about how many seconds?
5 - 6 seconds
This enzyme is involved conversion of two ADP to one ATP and one adenosine monophosphate (AMP)
adenylate kinase
The transfer of a phosphate from a molecule called _____ by the enzyme creatine kinase from ADP to form ATP.
creatine phosphate
A type of production of ATP during intensive short-term exercise.
Anaerobic
A type of production of ATP during most exercise and normal
conditions
Aerobic
True or False?
When a muscle fiber is working too strenuously for ATP stores and creatine phosphate to be able to provide enough ATP, aerobic respiration predominates.
False,
When a muscle fiber is working too strenuously for ATP stores and creatine phosphate to be able to provide enough ATP, anaerobic respiration predominates.
It is a temporary state of reduced work capacity.
Fatigue
True or False? Without fatigue, muscle fibers would be worked to the point of structural damage to them and their supportive tissues.
True
Mechanisms of fatigue include:
✔ Acidosis and ATP depletiondue to either an increased ATP consumption or a decreased ATP production
✔ Oxidative stress, which is characterized by the buildup of excess reactive oxygen species (ROS; free radicals)
✔ Local inflammatory reactions
It is the lag time between when a person begins to exercise and when they begin to breathe more heavily because of the exercise.
Oxygen deficit
_______ is the lag time before breathing returns to its preexercise rate once exercise stops.
Excess postexercise oxygen consumption
______ cells are non-striated small, spindle-shaped muscle
cells, usually with one nucleus per cell. It comprise organs controlled involuntarily, except the heart. Neurotransmitter substances, hormones, and other factors can stimulate it.
Smooth muscle
This type of muscle is long, striated, and branching, with usually
only one nucleus per cell. It is striated as a result of the sarcomere arrangement. Its contraction is autorhythmic.
Cardiac Muscle
Cardiac muscle cells are connected to one another by specialized
structures that include desmosomes and gap junctions called
_______ .
intercalated disks
It connects skeletal muscle to bone.
tendon
These are broad, sheetlike tendons
Aponeuroses
It is a band of connective tissue that holds down the tendons at each wrist and ankle.
retinaculum
Skeletal muscle attachments have an origin and an insertion, with the _____ being the attachment at the least mobile location.
origin
It is the end of the muscle attached to the bone undergoing the greatest movement.
Insertion
The part of the muscle between the origin and the insertion
Belly
A group of muscles working together are called ____ .
agonists
A muscle or group of muscles that oppose muscle actions are termed _____.