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What does the acronym DISHAAL stand for?
Disorientation, abnormal Interactions, Sleep/wake cycle disturbances, House soiling, Activity changes, Anxiety, and Leaning/memory changes.
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List at least seven signs of CDS
Wandering, anxiety, confusion, urinating/defecating in the house, pacing (often at night), less interaction with the owners, not recognizing familiar people/animals/commands, less interest in eating/playing/walking/socializing, restlessness, waking up in the night and/or increased daytime sleeping, inactivity, increased vocalization (often at night), going to unusual places, can't locate food dropped on the floor, and/or getting lost in familiar environments.
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CDS is essentially the canine equivalent of what human disease?
Alzheimer's
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After what age is CDS typically noted?
9 years of age
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What age related changes are noted in the brains of dogs with CDS?
Accumulation of beta-amyloid protein in the brain, reduced blood flow, and dysfunctional neurons.
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How is a diagnosis of CDS made?
Primarily with a combination of history and physical exam. And MRI can also be done to look for abnormalities in the brain.
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What dietary changes can be made to slow the progression of CDS and alleviate symptoms?
A diet higher in antioxidants, fats, and fatty acids can help protect and promote brain health.
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What specific dietary supplement can be used to help slow the progression and alleviate symptoms of CDS?
Senilife
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What is an important component of Senilife?
Medium-chain triglycerides.
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Based on a study in humans performed in 2022 (Use of medium chain triglyceride (MCT) oil in subjects with Alzheimer's disease: A randomized, double‐blind, placebo‐controlled, crossover study, with an open‐label extension), how is it thought that MCT's aid in slowing and alleviating the symptoms of Alzheimer's?
If the brain cannot utilize glucose efficiently as a form of fuel, MCT's serve as a nutritional source of ketones to supply the brain with alternative fuel.
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What drugs, or class of drugs, can be used to help slow the progression of or alleviate existing symptoms of CDS?
MAO inhibitors, propentofylline (Europe).
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What is something that owners can do at home to help slow the progression of CDS, or alleviate symptoms?
Cognitive enrichment in the form of exercise, social interactions, providing new toys, and teaching new commands.
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