drug therapy Guidelines 2021

  1. Aspirin Indications
    Acute coronary syndrome. cardiogenic pulmonary Oedema
  2. aspirin presentation
    300 mg chewable or soluble tablet
  3. aspirin indications
    • • Acute Coronary Syndrome
    • > Including  Acute Cardiogenic Pulmonary Oedema.
  4. Aspirin
    contra indications
    • • Known allergy or hypersensitivity to NSAIDs
    • Chest pain associated with psychostimulant overdose with
    • SBP>160mmHg
    • • Bleeding or clotting disorders
    • • Suspected aortic aneurysm
    • • Active and current gastrointestinal bleeding or ulcers
    • • Patient <18 years of age.
  5. Aspirin
    precautions
    • • History of peptic ulcers
    • • Asthma
    • • Patients on other anticoagulant medications
    • • Pregnancy.
  6. Aspirin
    side-effects
    • Epigastric discomfort or pain
    • Gastritis
    • Gastrointestinal bleeding
    • • Nausea and/or vomiting
    • • Bronchospasm (rare)
    • • Increased bleeding times
    • • Hypersensitivity reaction.
  7. Aspirin
    dose
    • Adult
    • 300 mg PO
    • No repeat, not required it evidence of aspirin300mg+ in preceding 12 hours

    Max dose 300mg
  8. Adrenaline
    presentation
    1mg / 1 ml Ampoule
  9. Adrenaline

    indications
    • •Cardiac arrest
    • • Croup or upper airway stridor
    • • Anaphylaxis or severe allergic reaction
    • • Severe asthma
    • • Inadequate perfusion (cardiac, non-cardiac, excluding
    • haemorrhage).
    • • Bradycardia with poor perfusion refractory to Atropine
  10. Adrenaline

    contra indications
    • • Known allergy
    • • Hypovolaemic shock without adequate fluid replacement.
  11. Adrenaline

    precautions
    • • Elderly and frail
    • • Hypertension
    • • Patients on monoamine oxidase inhibitors (MAOI)
    • • Higher doses may be required for patients on beta blockers.
  12. Adrenaline

    side-effects
    • • Tachycardia/palpitations
    • • Hypertension
    • • Headache
    • • Nausea and/or vomiting
    • • Pupil dilation
    • • Anxiety
    • • Arrhythmia.
  13. Adrenaline dose cardiac arrest
    Adult
    • ADULTS
    • 1mg IV/10
    • Repeat at 4 min (every second cycle) as required
    • No max dose
    • ICP
    • Infusion if perfusion remains poor post ROSC
    • 3mg/50ml (1ml/hr = 1microg/min) commence
    • at 2.5-5microg/min (2.5-5ml/hr)
    • Max rate 50-100microg/min (50-100ml/hr)
  14. Adrenaline cardiac arrest
    paediatric
    • >1yr 10microg/kg IVI/IO
    • <1yr 100microg IVI/IO
    • Repeat at 4 min (every second cycle) as required
    • ICP
    • Infusion if perfusion remains poor post ROSC
    • 300microg/50ml (0.1 microg/min = 1ml/hr)
    • commenced at 0.05microg/kg/min
    • Max rate 0.5microg/kg/min
    • Consider adult preparation if rate exceeds 60ml/hr,
    • and adjust to concentration accordingly.
  15. Adrenaline  Dose
      Croup or upper airway Stridor
    • ADULTS and PAEDIATRIC
    • 5mg Nebulised
    • For upper airway stridor, repeat once if required
    • Max dose 10mg
  16. Adrenaline
    dose
    anaphylaxis or severe allergic reaction
    Adult
    • 500microg IMI
    • Repeat at 5 min as required
    • No max dose

    • 5mg Nebulised
    • For upper airway stridor
    • No repeat dose
    • ICP 
    • 10-20microg IV/IO
    • Repeat at 1 min as required
    • No max dose
    • Consider infusion if perfusion remains poor
    • 3mg/50ml (1ml/hr = 1microg/min) commence
    • at 2.5microg/min
    • Max rate 10microg/min
  17. Adrenaline

    dose

    anaphylaxis  or severe allergic reaction

    paediatric
    • >6 years 300microg IMI
    • <6 years 150microg IMI
    • Repeat at 5 min as required
    • No max dose
    • 5mg Nebulised
    • For upper airway stridor
    • No repeat dose
    • ICP
    • 2microg/kg IV/IO
    • Single dose not to exceed 50microg
    • Repeat at 2 min
    • No max dose
    • Consider infusion if perfusion remains poor
    • 300microg/50ml (0.1microg/min = 1ml/hr)
    • commenced at 0.05microg/kg/min
    • Max rate 0.5microg/kg/min
    • Consider adult preparation if rate exceeds 60ml/hr,
    • and adjust to concentration accordingly.
  18. Adrenaline
    dose
    severe asthma adult
    • 500 microg IMI
    • Repeat at 5 min as required
    • No max dose
    • ICP
    • 10-20 microg IV/IO
    • Repeat at 1 min as required
    • No max dose
    • Consider infusion if multiple boluses required
    • 3mg/50ml (1ml/hr = 1 microg/min) commenceat 2microg/min (2ml/hr)
    • Max rate 15microg/min (15ml/hr)
  19. Adrenaline
    dose
    severe asthma paediatric
    • >6 years 300 microg IMI
    • <6 years 150microg IMI
    • Repeat at 5 min as required
    • No max dose
    • ICP
    • 1-2microg/kg IV/10
    • Single dose not to exceed 50mcg.
    • Repeat at 2 min
    • No max dose
    • Consider infusion if multiple boluses required
    • 300microg/50ml (0.1microg/min = 1ml/hr)
    • commenced at 0.05microg/kg/min
    • Max rate 05microg/kg/min
    • Consider adult preparation if rate exceeds 60ml/hr,
    • and adiust to concentration accordingly.
  20. Adrenaline 
    dose
    inadequate profusion refectory to fluid resuscitation excluding haemorrhagic causes
    ICP ONLY
    • 10-20microg IV/IO boluses initially, if
    • extremely poorly perfused consider
    • 50-100microg if required
    • Repeat at 1 min as required
    • no maximum dose

    • Paediatric
    • 1-2microg/kg IV/IO boluses if required
    • Single dose not to exceed 50microg
    • Repeat at 2 min
    • No max dose

    • Infusion adult
    • 3mg/50ml (1ml/hr = 1microg/min) commence
    • at 5microg/min (5ml/hr)
    • Max rate 50-100microg/min (50-100ml/hr)

    • Infusion Paediatric
    • 300microg/50ml (0.1microg/min = 1ml/hr)
    • commenced at 0.05microg/kg/min
    • Max rate 0.5microg/kg/min
    • Consider adult preparation if rate exceeds 60ml
    • and adjust to concentration accordingly.
  21. Adrenaline
    dose bradycardia with Poor  or inadequate perfusion refractory  to Atropine
    ICP ONLY
    • Adult
    • 20-50microg IV/IO
    • Repeat at 1 min as required
    • 10microg/min

    • Paediatric
    • 2microg/kg IV/IO
    • Single dose not to exceed 50 microg
    • Repeat at 2 min
    • No max dose

    • Consider infusion if perfusion remains poor
    • adult
    • 3mg/50ml (1ml/hr = 1microg/min) commence
    • at 2.5microg/min
    • Max rate 10microg/min, then consider TCP.
    • Paediatric
    • 300microg/50ml (0.1microg/min = 1ml/
    • commenced at 0.05microg/kg/min

    • Max rate 0.5microg/kg/min
    • Consider adult preparation if rate exceeds 60ml/hrand adjust to concentration accordingly.
  22. Droperidol 
    presentaion
    • 10mq/2ml Ampoule
    • or
    • 2.5mg/1 ml Ampoule
  23. Droperidol 
    indications
    • • Acute psychosis
    • • Acute agitation and behavioural disturbance (SAT Score 2+).
  24. Droperidol 
    contraindications
    • • Known allergy
    • • Known Parkinsonism (Same symptoms as disease but caused by medication)
    • • Children <8 years of age
    • • Previous dystonic reaction to Droperidol.
  25. Droperidol 
    precautions
    • • Elderly and frail
    • • Concomitant use with other CNS depressants
    • • Patients on medications which may cause QT prolongation, or
    • history of congenital long QT syndrome.
  26. Droperidol 
    side effects
    • • Brady or tachycardia,
    • • Extrapyramidal effect or dystonia (rare)
    • • Hypotension
    • QT prolongation (rare).

    • akathisia =
    • restless. hard 2 sit still
    • tapping fingers hands- legs crossed n uncrossing.
    • Dystonia = involuntarily Muscle contractions
  27. Droperidol 
    dose
    adult
    • >16 and <65 years 10mg IMI
    • Repeat once if required at 20 mins
    • Max dose 20mg
    • >65 years or frail 5mg IMI
    • Repeat once if required at 20 minutes. max dose 10mg
    • ICP
    • >16 and <65 years 10mg IV
    • Repeat once if required at 20 minS
    • max dose 20mg
    • >65 years or frail 5mg IV
    • Repeat once if required at 20 mins
    • max dose 10mg
  28. Droperidol 
    dose
    paediatric
    • 8-15 years 0.1mg/kg IMl
    • Single maximum dose 5mg
    • Repeat once if required at 20 min
    • Max dose 10mg
    • (Note: paediatric administration for
    • non-ICP is consult only)
    • ICP
    • 8-15 years 0.1mg/kg IV
    • Single maximum dose 5mg
    • Repeat once if required at 20 min
    • Max dose 10mg
  29. Oxytocin 
    Presentation
    10iu/1ml ampoule
  30. Oxytocin 
    Indications
    • •Active management of third stage labour
    • •management of post partum Haemorrhage
  31. Oxytocin 
    contraindications
    • • known allergy
    • • Undelivered foetuses
    • • severe toxaemia (pre-eclampsia)
  32. oxytocin
    side effects
    • • Nausea and/or vomiting
    • • Headache
    • • Bradycardia
    • • Tachycardia.
  33. Oxytocin 
    side effects
    • • Nausea and/or vomiting
    • • Headache
    • • Bradycardia
    • • Tachycardia.
  34. Oxytocin 
    dose
    Active management of the stage Labour.
    PPH
    • 10iu/1ml IMI
    • Max dose 10iu (3rd stage labour)

    • (PPH) Repeat once at 5 min if bleeding continues 
    • Max dose 20iu (PPH)
  35. Olanzapine 
    Presentation
    10mg orally dissolving tablet
  36. Olanzapine 
    indications
    Mild to moderate agitation -SAT score 1-2
  37. Olanzapine 
    contraindications
    Known  allergy
  38. Olanzapine 
    precautions
    • • Alcohol intoxication, avoid over sedation
    • • Elderly, frail and young children are more susceptible to adverse effects
    • • May be less effective with alcohol withdrawal and patients on stimulant
    • • In pregnancy only administer if benefit outweighs any potential risks
    • • Similar presentation to Ondansetron, care must be taken to ensureright medication given.
  39. Olanzapine 
    side effects
    • • Dizziness
    • • Sedation
    • • QT prolongation and extrapyramidal reactions unlikely at approved doses
  40. Olanzapine 
    dose
    • 10mg SL
    •  5mg SL if under 60kg, frail or elderly.
    • Repeat after 30 min
    • Max dose 20mg
    • Consult only for <16 years
  41. Amiodarone
    Presentation
    300mg / 3ml ampoule
  42. Amiodarone
    indicatons
    • • Cardiac arrest with VF or VT refractory to cardioversion
    • • Sustained conscious VT without haemodynamic compromise.
  43. Amiodarone
    Contra indications
    • • Second or Third degree heart block without PPM
    • • Hyperkalaemia
    • » Known allergy
    • »› Haemodynamically unstable
    • > Other therapies that prolong QT intervals
    • › Pregnancy
    • •Tricyclic and certain other cardiotoxic overdoses.
  44. Amiodarone
    Precautions
    • • Thyroid disease
    • • Ondansetron administration in past 24 hours
    • • Hypotension
  45. Amiodarone
    side-effects
    • • Hypotension
    • • Bradycardia
    • • Nausea and/or vomiting
    • • Peripheral paraesthesia.
  46. Amiodarone
    doses adult 
    cardiac arrest with VF or VT
    • Adult 
    • 300mg IV/IO
    • Repeat at 150mg per guideline
    • Max dose 450mg
  47. amiodarone
    doses 
    paediatric
    • 5mg/kg IV/IO
    • Repeat once per guideline
    • Max dose 10mg/kg or total of 450mg
  48. Amiodarone
    dose adults
    sustained conscious VT
    ICP ONLY
    • Infusion 5mg/kg
    • 300mg in 20mls at 60ml/hr (20 min)
    • single-dose only
    • Max – 300 mg
Author
coldy175
ID
356906
Card Set
drug therapy Guidelines 2021
Description
Updated