Antihistamines-2nd generation

• Second generation
• Class: Piperazine peripheral selective

Indication: allergic rhinitis and chronic idiopathic urticaria

MOA: selective agents that bind only peripheral receptors and as a group are less sedating

Racemic mix: 10 mg qd

Dose needs to be reduced for renal and hepatic failure

• Second generation
• Class: piperazine peripheral selective

• One enantiomer
• Dose= adults 5 mg qd=dose is cut in half

Indications: allergic rhinitis and chronic idiopathic urticaria 

MOA: selective agents that bind only peripheral receptors and as a group are less sedating

approved for use in children 6-11 years: get one half 5mg tablet

• Second generation
• Class: Piperidine peripheral selective 

Indication: Allergic rhinitis and urticaria

MOA: selective agents that bind only peripheral receptors and as a group are less sedating

• second generation
• Class: Piperidine peripheral selective

Indications: seasonal allergic rhinitis (children 6 years of age or older) and chronic idiopathic urticaria

MOA: selective agents that bind only peripheral receptors and as a group are less sedating

less sedation at higher doses than other 2nd generation drugs

taking with fruit juice can decrease absorption by up to 70% by inhibiting OATP1A2 transporters in the Intestinal tract.

New molecular entity

Indication: prevention of itching associated with seasonal allergic rhinitis

MOA: Relatively selective dual H1-receptor antagonist AND a inhibitor of histamine and other mediator release from mast cells by acting as a mast cell stabilizer--DUAL MECHANISM

No alpha-adrenergic, dopaminergic or muscurininc type 1/2 receptor effects