- Low GI absorption and high first-pass metab.
- Altered prodrug groups
Indications: Seasonal rhinitis and prevention of reoccurrence of nasal polyps following surgical removal. Use in children is NOT indicated for all products
MOA: Adrenal corticosteroids with basic glucocorticoid activity and actions---exact mechanism in the nasal tissue is unknown (decreased inflammatory mediators)
Warning: use Caution in pateints on systemic alternate-day corticosteroid treatment since HPA suprression likelihood my increase---local delivery can reduced the systemic glucocorticoid activity, some weak mineralcorticoid activity
Metab: primary in liver, highly protein bound with excretion
localized infections from Candida albicans
Patient info: contact MD if exposed to chicken pox/measles
