Gastric acidifiers/Digestive enzymes/and other

Indication: counter the deficiency of HCl in the GI tract which many destroy unwanted bacterial and viral pathogens that are in foods

Requires months of therapy

MOA: slowly solubilizes cholesterol gall stones located in the gall bladder

indication: treatment of bile acid synthesis disorders due to single enzyme defect

MOA: bile acids facilitate fat digestion and absorption by forming mixed micelles, and facilitate absorption of fat-soluble vitamins in intestine

Indication: primary biliary cholangitis

MOA: an agonist for FXR, a nuclear receptor expressed in the liver and intestine. FXR is a key regulator of bile acids by suppressing de novo synthesis from cholesterol as well as by increaed transport of bile acids out of hepatocytes