Crohns/Ulcerative Colitis Drugs

indication: chronic inflammatory bowel diseases like ulcerative colitis

indication: maintenance of remission of ulcerative colitis in patients intolerant of sulfasalazine

Indications: ulcerative colitis, rheumatoid arthritis, juvenile RA

very selective, only some gets circulated

Indication: mild to moderate ulcerative colitis

MOA: 5-ASA inhibits leukotriene production reduces interleukin-1 and TNFalpha signaling & has antiproliferative effects

Indication: Treatment of Crohn's disease

80-90% first-pass effect metabolism which limits systemic availability

MOA: inhibits TNF alpha; prevent cascade release of a large number of pro-inflammatory cytokines that lead to severe inflammation

MOA: monoclonal antibody that targets integrin receptors on leukocytes, preventing binding to gut vascular receptors and prevent leukocyte migration inhibiting the inflammatory cascade

MOA:an integrin receptor antagonist is humanized IgG1 monoclonal antibody produced in Chinese hamster ovary cells that binds to the human alpha 4 beta integrin

very expensive

intravenous administration