Pathology Sharad

1. In which of the following organ, liquefactive necrosis is commonly found :

2. In parotid tumor, perineural infiltration is seen in:

3. Which of the following is not an important feature of pseudohypoparathyroidism :

4. Most common intracranial tumor is :

5. Which of the following is not seen in MEN 2 B:

6. Which of the following is not found in wiskott-aldrich syndrome :

7. Which of the following is true regarding libman-sachs endocarditis :

8. In which of the following condition, vitamin K deficiency is seen :

9. Gitter cells are :

10. Phagocytes in central nervous system are :

11. Which of the following carcinoma of lung secretes PTH like substance :

12. Which of the following is not involved in sipple’s syndrome :

13. Not a component of sipple’s syndrome :

14. Which of the following is not decreased in nephritic syndrome :

15. Myofibroblasis are present in :

16. Which of the following is true regarding hereditary spherocytosis :

17. MacCallum’s plaque is the diagnostic feature of :

18. MacCallum’s plaques are present in :

19. Which of the following is the most common type of carcinoma thyroid :

20. Most common histological type of Hodgkin’s disease is :

21. Cytokeratin is a marker for :

22. Rosette arrangement of cell is present in :

23. Rapidly progressive glomerulonephritis is not caused by :

24.Mallory body is :

25.Chromosomal translocation in Burkitt’s lymphoma is between :

26. Which of the following is not involved in polyarteritis nodosa ;

27. Pale infract is seen in all except :

28. pulmonary infarcts are :

29. Which of the following is the earliest lesion in atherosclerosis :

30. Crooke’s hyaline change is seen in :

31. Aschoff bodies are seen in :

32.. orbital metastasis is common in :

33. Russell bodies are found in :

34. After 72 hours of myocardial infarction, the predominant cells are :

35. Which of the following stain is used for pneumocystis carinil:

36. Which of the following is true regarding heart failure cells :

37. Heart failure cells have :

38. Peripheral necrosis of liver is caused by :

39. Centrilobular necrosis of liver is seen in :

40. Kaposi’s sarcoma arises from :

41. RH incompatibility involves :

42. Which of the following s the intermediate form of non-Hodgkin’s lymphoma :

43. Reaction found in blood transfusion is :

44. Programmed cell death is known as :

45. Which of the following is the most common tumor of heart :

46. The most common cause of lungs abscess is :

47. In ulcerative colitis, the site usually involved is :

48. In which of the following condition , periglomerular fibrosis and thyroidization of kidney is seen :

49. Flea bitten kidney is seen in :

51. Which of the following is the best for diagnosing system lupus erythematosus:

52.Which of the following organ is not involved in wermer’s syndrome :

53. In which of the following subendothelial dense deposits corresponding to wire loop under light microscope are seen :

54. Focal segmental glomerulosclerosis (FSG) does not occur in :

55. Lipodystrophy is associated with :

56.Gandy Gamma bodies are seen in :

57. Which of the following is not seen in hypernephroma :

58. Which of the following is the most common site of myocardial infarction :

59. In an inflammation, macrophases are generally derived from

60. Which of the following is the pathological change that occurs in malignant hypertension :

61. In malignant hypertension ,the characteristic finding in kidney is :

62. Which of the following is true regarding Epulis :

63. In rabies, most common pathological change is :

64. Amyloid is a :

65. Normocytic normochromic anemia is not seen in :

66. myentric ganglion cells are absent in which of the following :

67. Which of the following is true regarding Berry’s aneurysm ;

68. Which of the following is least commonly involved in berry aneurysm :

69. Deposition of which of the following element occurs in Wilson’s disease ;

70. Leukocyte alkaline phosphate is not raised in :

71. which of the following is inhibited by aspirin :

72. In which of the following condition, Acute cor pulmonale is seen :

73. Alpha fetoprotein levels are raised in :

74. Alpha fetoprotein levels are raised in :

75. ARF and hemoptysis is seen in :

76. Renal papillary necrosis is not seen in :

77. the most common change in arterosclerotic vessel is :

78. In which of the following,dystrophic calcification is not seen :

79. Which of the following is the most common cause of aortic aneurysm :

80. The presenting feature of amyloidosis of kidney is :

81. In muscular dystrophy , the characteristic finding is :

82. the liver change in Reye’s syndrome is ;

83. Which of the following is false regarding IgG:

84. Which of the following HLA is important in diabetes mellitus :

85. Which of the following produces prostacyclin :

86. Most common site of pleomorphic adenoma is ;

87. An elderly male has anemia and splenomegaly. His peripheral blood smear reveals tear drop shaped cells. Bone marrow examination is normal. He is suffering from :

88. Hairy cells leukemia is due to :

89. Which of the following has malignant potential :

90. In which of the following amyloid is best seen :

91. Cystic fibrosis is inherited as:

92. Gynecomastia is not associated with :

93. Which of the following is not seen in anemia of chronic diseases:

94. Which of the following is the primary lymphoma of skin :

95. CEA is a tumor marker of carcinoma of :

96. HLA B 27 associated in :

97. Acid phosphatase is increased in carcinoma of :

98. Rodent ulcer is…..carcinoma :

99. Psammoma bodies are seen in :

100. Prussian blue is used for staining

101. In marfan’s syndrome, the aortic aneurysm occues in :

102. Which of the following is inherited as autosomal dominant trait :

103. Which of the following is a component of Tetralogy of fallot :

104. Which of the following is true regarding petuz-jeghers tumor :

105. In petuz-jeghers syndrome, polyps are seen in which part of GIT:

106. Carcinoid is most common in :

107. Which of the following is false regarding type A fundal gastritis :

108. In which of the following,lines of Zahn are seen :

109. Lines of zain are found in :

110.. Which of the following pathological change does not occur in alzhelmer’s disease :

111. Platelet counts are normal in :

112. Which of the following is the primary pleural tumor :

113. Which of the following is not found in biological membrane ;

114. which of the following are not labile cells :

115. Laminin is seen in :

116. Which of the following carcinoma is not associated with DIC:

117. Keratin is a marker of which of the following :

118. Not a cause of splenomegaly :

119. Which of the following is the most common benign tumor of liver :

120.psammoma bodies are seen in :

121. Which of the following does not cause acute tubular necrosis :

122. Which of the following is the most common site for brain abscess:

123. In which of the following is the most common site for brain abscess:

124.Which of the following is false regarding typhoid ulcer:

125. Regional enteritis commonly involves :

126. Skip transmural lesion is a characteristic feature of :

127. Which of the following is seen in glanzmann’s disease ;

128. In inflammation which of the following prostaglandin derivative is not involved :

129. In benign hypertension the most important change in arterioles is :

130. In benign hypertension which of the following is the most common pathological findings in kidney :

131. Which of the following is the least malignant site of carcinoid tumor:

132. Which of the following mediator does not promote chemotaxis :

133. In diabetes mellitus, the most common renal lesion is :

134. In which of the following condition, serum amylase is not increased :

135. From which of the following,major basic proteins are derived ;

136. Which of the following has best prognosis in hodgkin’s disease ;

137. All of the following cause amyloidosis except :

138. which of the following is not of endothelial origin :

139. Which of the following is a vitamin k dependent factor ;

140. Which of the following is not a predisposing factor for carcinoma esophagus :

141. Which of the following is responsible for green house effect:

142. Which of the following is not a clinical feature of minimal change glomerulonephritis :

143. For myocardial infarction, the average time required for complete healing is :

144. In nonsmokers the most common type if carcinoma lung is :

145. Which of the following is the most common premalignant condition of oral carcinoma :

146. which of the following is not caused by zenc deficiency :

147. Toxic megacolon is seen in :

148. In which of the following condition ,hypertriglyceridemia is seen :

149. Which of the following is true regarding idiopathic thrombocytopenic purpura :

150. A child has minimal change disease which is well controlled by steroids, the most likely finding on light microscopy is :

151. Characteristic feature of minimal change disease is :

152. Which of the following gene prevents apoptosis :

153. Group b lymphocyte belongs to CD….

154. Gallbladder adenomyoma are always situated in ;

155. Prognosis of soft tissue sarcoma depends upon :

156. Which of the following is true regarding sideroblastic anemia :

157. Which of the following is the most common site of epithelioid leiomyoma :

158. In CLL most common cell type is :

159. In which of the following condition , there is linear IgG deposition in glomerilar basement membrane:

160. Homer Wright rosettes are seen in :

161. Violin string sign in perihepatitis is now mosty due to :

162. Most common carcinoma of lung is :

163. Half –life of neutrophill is :

164. Which of the following is present in platelets :

165. Which of the following is not an example of type III hypersensitivity :

166. Pheochromocytoma originates from ;

a. Neurons b. Mesenchymal cells

167. Thrombocytopenia is not associated with :

168. Tumor associated with polycythemia vera is :

169. which of the following is commonly affected in syphilis:

170. Tuberculosis bacillus cannot be phagocytised because of :

171. which of the following preservative is used for storing blood for transfusion :

172. Mycosis fungoides is :

173. Carcinoids do not produce :

174. Which of the following is the frequent site of extra-adrenal pheochromocytoma :

175. in pheochromocytoma, malignancy is indicated by :

176. in which of he following, APUD cells are seen :

177. Which of the following is true regarding langerhans’ cells :

178. Which of the following Is false regarding hereditary spherocytosis :

179. liver cirrhosis is not seen in :

180. Not associated with MEN type 2A ;

181. Which of the following causes lacunar infarcts :

182. A young man in his twenties presented with mass involving the duodeojejunal flexure and invading the renal papilla. Histopathological examination revealed lymphoma. Which of the following is true :

183. RBC casts in urine analysis, most likely source is :

184. which of the following tissue is most sensitive and vulnerable to lack of oxygen

185. Cloudly swelling is because of :

186. In which of the following disease PAS positive glycoprotein containing macrophages with in the lamina propria of intestinal mucosa is found :

187. Reversible cell injury is not characterized by :

188. Which of the following is true regarding irreversible injury in cell:

189. In cyclooxygenase pathway which of the following is not produced :

190. All of the following are carcinogenic except :

191. Splenic infarct is not seen in :

192. AL amyloid originates from :

193. Macrocytosis is not seen in :

194. In which of the following condition ,lipoprotein X is raised :

195. Which of the following is the earliest response to iron therapy :

196. Which of the following is the correct ration of CSF and blood sugar:

197. Antineutrophill cytoplasmic antibodies are not associated with :

198. Which of the following is not seen in amyloid kidney :

199. A patient has increased red cell protoporphyrin . his MCV is 60, hemoglobin 6.5gm% and MCH 15/G. Most probable diagnosis is :

200. In primary amyloidosis, the major fibril protein is:

201. Anti-smith antibodies are found in :

202. Wire – loop lesions are seen in :

203.kimmelstiel –wilson lesions are seen in :

204. Which of the following is an essential component of granuloma ?

205. A female presents with hilar lylmphadenopathy, pulmonary symptoms and skin nodules. The tuberculin test shows 5 mm induration. Which of the following is most likely in skin biopsy ?

206. Lacunar cells are found in which of the following types of Hodgkin’s disease ?

207. CEA is elevated in which of the following malignancies ?

208. Which of the following carcinomas does not have carcinoembryonic antigen ?

209. All of the following are associated with increased risk of colonic carcinoma except

210. In polycystic kidney disease, cysts are not found in ?

211. Polycystic kidney is most frequently associated with :

212. ‘Tram track’ appearance is seen in which of the following nephropathies

213. All of the following are risk factors for deep vein thrombosis(DVT) except :

214. All of the following conditions may predispose to pulmonary embolism except:

215. Which of the following is the most common location of hypertension hemorrhage ?

216. Which of the following is the most common location of hypertensive hemorrhage ?

217. The most common site for hypertensive intracerebral bleed is :

218. Most common site for hypertensive intracranial bleeding is :

219. eggshell calcification is seen in :

220. Leuloerthroblastic picture may be seen in all of the following except :

221. Which of the following is false regarding leukoerythroblastosis ?

222. head and neck cancer is associated with which gene ?

223. A girl is having breast carcinoma. Her mother died from ovarian carcinoma. You will ask for examination of which gene:

224. Calcitonin is a tumor marker in :

225. Medullary carcinoma aof the thyroid is associated with which of the following syndrome ?

226. Calcitonin is a marker of

227. Lardaceous spleen is found in :

228. Lardaceous spleen is seen due to deposition of amyloid in ;

229. Aschoff bodies in rheumatic heart disease show all the following features except:

230. Which of the following is not a content of Aschoff nodule ?

231. In rheumatic fever, which of the following type of pericarditis is most common?

232.In rheumatic fever the exudate is

233. Liver biopsy is normal in :

234. Accumulation of spingomyelin in phagocytic cells is a feature of :

235. Phagocytosis in brain is done by

236. In malignant hypertension, the characteristic pathological change is :

237. The m4 stage in AML is associated with the presence of :

238. In which of the following DIC is seen ?

239. In which of the following condition,anti-glomerular basement membrane antibodies with necrotizing hemorrhagic interstitial pneumonitis is seen

240. In which of the following condition ,there is linear deposition of IgG along the basement membrane?

241. In cirrhosis, the splenomegaly is :

242. Centrilobular necrosis is not seen in :

243. Which of the following is the most common type of cell death due to sudden cessation of blood supply ?

244. In Philadelphia chromosome translocation seen is:

245. CML is associated with all of the following except :

246. Gluten-sensitive enteropathy is most strongly associated with

247. Abelson oncogene is associated with which of the following leukemia ;

248. In CML the translocation occurring is :

249. M4 in the classification of AML denotes which of the following stages;

250. Von willebrand’s disease is transmitted as:

251. X-linked dominant inheritance pattern is seen in:

252. Myotonic dystrophy is inherited as:

253. In multiple myeloma, lytic lesions are most common at :

254. Late manifestation of multiple myeloma is :

255. a renal biopsy from a 56 year old woman with progressive renal failure for the past 3 years shows glomerular and vascular deposition of pink lamorphous material. It shows apple- green birefringence under polarized light after congo red staining. These deposits are positive for lambda light chains. The person is most likely to suffer from :

256. in which of the following condition, alkaline phosphate level is not increased :

257. In multiple nmyeloma the amyloid protein is :

258. Increased expression of erb-2 gene is associated with ?

259. All the statements about lactoferrin are true , except :

260. Serum total lactate dehydrogenase level will not be raised in :

261. HTLV-1 is responsible for

262. Pseudopolyposis are seen in :

263. Most common cause of SVC obstruction is

264. Which of the following is the most common cause of SVC obstruction ?

265. Carcinoma of lung, which presents as SVC obstruction is

266. Mechanism of type II hypersensitivity reaction is ;

267. Which of the following are involved in ‘delayed’ hypersensitivity ?

268. Which of the following is a type IV hypersensitivity reaction ?

269. A 40 year old man has a chronic cough with fever for several months.the chest radiograph reveals diffuse reticulonodular pattern . microscopically intransbronchial biopsy there are focal areas of inflammation containing epithelioid cell granuloma, langhans giant cells and lymphocytes . these findings are typical for which of the following type of hypersensitivity immunologic responses?

270. Not an example of delayed hypersensitivity reaction :

271. Which of the following statements is not correct ?

272. A girl developed redness and swelling of ear lobes after wearing some earrings, this is an example of which of the following type of hypersensitivity ?

273. In post- streptococcal glomerulonephritis the type of hypersensitivity includes:

274. Which of the following is an example of immediate hypersensitivity /

275. Which of the following is the type I reaction ?

276. Which of the following is an example of type I hypersensitivity ?

277. HUS is characterized by all except :

278. Which of the following is the most common carcinoma of breast?

279. In young female, most common type of breast carcinoma is :

280. A 13 year old boy is referred for evaluation of nocturnal enuresis and short stature. His blood pressure is normal. The hemoglobin level is 8g/dl,urea 112 mg/ml, creatinine 6mg/dl,sodium 119meq/l, potassium 4mE/l ,calcium 7 mg/dl,phosphate 300U/L. urinalysis shows bilateral small kidneys small kidney sand the micturating cystourethrogram is normal. The most likely diagnosis is ;

281. upper GI endoscopy and biopsy from lower esophagus in a 48 years old lady with chronic heart burn shows presence of columnar epithelium with goblet cells. The feature is most likely consistent with :

282. Which of the following is different between natural killer cells and cytoxic T cells?

283. Which of the following is false regarding natural killer cells ?

284. Which of the following is common to natural killer cells and cytotoxic T cells?

285. Which of the following is pan –T- lymphocyte marker ?

286. Anti – Fibrillarin antibodies are seen in :

287. HIV- associate nephropathy is characterized by all of the following except :

288. Rapillary necrosis is seen in all the following except:

289. Which of the following is the most common cause if renal papillary necrosis ?

290.The correct sequence of cell cycle is :

291. In post- streptococcal glomerrulonephritis, crescents are:

292. In hemolytic anemia which of the following cell is specific for microangiopathy

293.In which of the following disease cylindrical dilation of renal tubules occur?

294.In hepatitis B,membranous glomerrulopathy is because of ;

295. A patient has lung carcinoma with nephritic syndrome. The nephritic syndrome is of which of the following types?

296. in which of the following c-ANAC is seen ?

297. Adenosine deaminase deficiency is associated with :

298. In which of the following carcinomas of lung, there is ectopic productin of ACTH:

299. Most sensitive and specific test for diagnosis of iron deficiency is :

300. Ferritin is decreased in :

301. Which of the following is the best test for assessing iron status?

302. Which of the following is due to ‘point’ mutation ?

303. Which of the following is true regarding sickle cell anemia ?

304.Which of the following cell types is most common in islets of langerhans of pancreas?

305. In nephritic syndrome which of the following is increased ?

306. The presenting feature of cerebral amyloid angiopathy is :

307. All of the following diseases are transmitted in autosomal recessive pattern except :

308. Which of the following diseases are transmitted in autosomal recessive pattern except :

309. Which of the following type of nephritic syndrome does not respond well to steroid therapy ?

310. maximum endocapillary proliferation is seen in which of the following nephropathies?

311. Which of the following is not a characteristic features of anemia of chronic diseases/

312. Antinuutrophil cytoplasmic antibody ( ANCA) is most sensitive and specific marker for which of the following

313. All of the following can cause of megakaryocytic thrombocytopenia, except :

314. All of the following diseases cause massive splenomegaly, except:

315. Which one of the following soft tissue sarcomas frequently mestastasises to lymph nodes:

316. Troponin T is a marker of ;

317. Calcification of soft tissue with out any disturbance of calcium metabolism is called

318. A baby girl with ambiguous genitails is found to have 21 hydroxylase deficiency of the salt wasting type . which of the following karyotypes would you except to find;

319. Virchow’s triad includes all, except:

320. Most common cause of subarachnoid hemorrhage is :

321. Subdural hematoma most commonly results from :

322. Which of the following tumors have an increased elevation of placental alkaline phosphates in the serum as well as a positive immunohistochemical staining for placental alkaline phosphates ?

323. Lung biopsy in acute hepatitis due to hepatitis B virus is likely to show all of the following, except :

324. A 20 years old female, asymptomatic,not requiring blood transfusion, presents with hemoglobin 13.0 G%. Her Hb-F level are 95%, HBA 2 is 1.5 %. Which of the following is the most likely diagnosis?

325. HIV associated nephropathy is a type of :

326. Endoscopic biopsy from a case of helicpopbater pylori related duodenal ulcer is most likely to reveal:

327. which of the following is detected by the antigen detection test used for diagnosis of plasmodium falciparum malaria?

328. An example of a tumor suppressor gene is :

329. which of the following conditions commonly predisposes to colonic carcinoma?

330. In von Hippel-Lindau disease, the retinal vascular tumors are often associated with intracranial hemangioblastoma. Which of the following region is associated with with such vascular abnormalities in this syndrome?

331. A simple bacterial test for mutagenic carcinogens is :

332. Which of the following is the most common location of hypertensive bleed in the brain ?

333. Which type of amyloidosis is caused by mutation of the transthyretin protein ?

334. In Familial Mediterranean fever, the gene encoding the following protein undergoes mulation :

335. In apoptosis, Apaf-1 is activated by release of which of the following substances from the mitochondria?

336. All of the following CSf finding are present intuberculous meningitis (TBM), except:

337. Which of the following stains is specific for amyloid?

338. Which one of the following disease characteristically causes fatty change in lever?

339. A woman with infertility receives an ovary transplant from her sister who is an identical twin. What type of graft it is?

340. Type I hypersensitivity is mediated by which of the following immunoglobulins?

341. Aschoff nodules are seen in :