Pathology Sharad

  1. 1. In which of the following organ, liquefactive necrosis is commonly found :
    a. Liver b. Brain(CNS) c. Heart d. Lung
  2. 2. In parotid tumor, perineural infiltration is seen in:
    • a. Adenoid cystic carcinoma b. Adenolymphoma
    • c. Mixed parotid tumor d. Cylindrioma
  3. 3. Which of the following is not an important feature of pseudohypoparathyroidism :
    • a. Developmental abnormalities b. Hypocalcemia
    • c. Hyperphosphatemia d. response to injected parathyroid hormone
  4. 4. Most common intracranial tumor is :
    a. Glioma b. Medulloblastoma c. Meningioma d. Secondaries
  5. 5. Which of the following is not seen in MEN 2 B:
    • a. Pheochromocytoma b. Medullary thyroid carcinoma
    • c. Marfanoid features d. Hyperparathyroidism
  6. 6. Which of the following is not found in wiskott-aldrich syndrome :
    • a. Eczema is present
    • b. Thrombocytopenia is present
    • c. It is an autosomal recessive disorder
    • d. Bone marrow transplant is the treatment
  7. 7. Which of the following is true regarding libman-sachs endocarditis :
    • a. it is due to SLE b. Vegetations are sterile
    • c. Both side valves are defective d. All are correct
  8. 8. In which of the following condition, vitamin K deficiency is seen :
    • a. Obstructive jaundice b. Prehepatic jaundice
    • c. Hepatic jaundice d. None of the above
  9. 9. Gitter cells are :
    • a. Oligodendrocytes
    • b. Phagocytes in central nervous system
    • c. WEpidermal cells
    • d. Astrocytes
  10. 10. Phagocytes in central nervous system are :
    • a. Microgilla b. Oligodendrocytes
    • c. Astrocytes d. Ependymal cells
  11. 11. Which of the following carcinoma of lung secretes PTH like substance :
    a. Anaplastic type b. Large cell c. Squamous cell d. Oat cell
  12. 12. Which of the following is not involved in sipple’s syndrome :
    a. Thyroid b. parathyroid c. Pituitary d. Adrenal
  13. 13. Not a component of sipple’s syndrome :
    • a. Parathyroid hyperplasia b. Pituitary hyperplasia
    • c. pheochromocytoma d. Medullary carcinoma of thyroid
  14. 14. Which of the following is not decreased in nephritic syndrome :
    a. Ceruloplasmin b. Fibrinogen c. Transferrin d. Albumin
  15. 15. Myofibroblasis are present in :
    • a. Muscle septum b. Normal connective tissue
    • c. Bronchus d. Wound margin
  16. 16. Which of the following is true regarding hereditary spherocytosis :
    • a. It is an acquired membrane defect
    • b. It is due spectrin deficiency
    • c. It is due to defective hemoglobin synthesis
    • d. It is due to mechanical trauma to RCBs
  17. 17. MacCallum’s plaque is the diagnostic feature of :
    a. TOF b. MI c. Rheumatic endocarditis d. Infective endocarditis
  18. 18. MacCallum’s plaques are present in :
    a. Right ventricle b. left atrium c. Fourth ventricle d. Right atrium
  19. 19. Which of the following is the most common type of carcinoma thyroid :
    a. Anaplastic b. Medullary c. Follicular d. Papillary
  20. 20. Most common histological type of Hodgkin’s disease is :
    • a. Mixed cellularity type b. Lymphocyte predominant type
    • c. Nodular sclerosis type d. Lymphocyte depletion type
  21. 21. Cytokeratin is a marker for :
    a. Carcinoma b. Adenoma c. Lymphoma d. Sarcoma
  22. 22. Rosette arrangement of cell is present in :
    • a. Leydig cell tumor b. Retinoblastoma
    • c. Lymphosarcoma d. MEsothelioma
  23. 23. Rapidly progressive glomerulonephritis is not caused by :
    • a. SLE b. Post streptococcal glomerulonephritis
    • c. Diabetic nephropathy d. Goodpasture’s syndrome
  24. 24.Mallory body is :
    • a. Fat droplet in the cell b. altered mitochondrion
    • c. intermediate filament d. product of lysosomal degeneration
  25. 25.Chromosomal translocation in Burkitt’s lymphoma is between :
    a. T(8;14) b. T(7;14) c. T(8;16) d. T( 11;22)
  26. 26. Which of the following is not involved in polyarteritis nodosa ;
    • a. Arteries of kidney b. Arteries of liver
    • c. Ariteries of pancreas d. pulmonary arteries
  27. 27. Pale infract is seen in all except :
    a. Spleen b. kidney c. Lung d. Heart
  28. 28. pulmonary infarcts are :
    a. Yellow b. Grey c. Red d. Green
  29. 29. Which of the following is the earliest lesion in atherosclerosis :
    a. Fibrofatty plaque b. Fibrous plaque c. Atheroma d. Fatty streaks
  30. 30. Crooke’s hyaline change is seen in :
    • a. Basophills of pituitary gland in cushing’s syndrome
    • b. Chronic hepatitis B
    • c. yellow fever hepatocytes
    • d. Voluntary muscle
  31. 31. Aschoff bodies are seen in :
    a. COPD b. Rheumatic fever c. pulmonary embolism d. Rheumatoid arthritis
  32. 32.. orbital metastasis is common in :
    a. Neuroblastoma b. Hypernephroma c. Hepatoma d. Melanoma
  33. 33. Russell bodies are found in :
    • a. parkinson’s disease b. Multiple myeloma
    • c. systemic lupus erythematosus d. Yellow fever
  34. 34. After 72 hours of myocardial infarction, the predominant cells are :
    a. Mast cells b. macrophages c. Lymphocytes d. Leucocytes
  35. 35. Which of the following stain is used for pneumocystis carinil:
    • a. Methylene blue b. Methenamine silver
    • c. hematoxylin and eosin d. Gram stain
  36. 36. Which of the following is true regarding heart failure cells :
    • a. Lipofuscin granules in cardiac cells b. Pigmented alveolar macrophages
    • c. Pigmented pancreatic aciner cells d. Pigmented cells seen in liver
  37. 37. Heart failure cells have :
    a. Myoglobullin b. Albumin c. Lipofuschin d. Hemosiderin
  38. 38. Peripheral necrosis of liver is caused by :
    a. Carbontetrachloride b. benzene c. Phosphorus d. Rifampicin
  39. 39. Centrilobular necrosis of liver is seen in :
    • a. Arsenic poisoning b. Carbon tetrachloride poisoning
    • c. Ethanol poisoning d. Phosphorus poisoning
  40. 40. Kaposi’s sarcoma arises from :
    a. Capillaries b. dermis c. Connective tissue d. Fibrous tissue
  41. 41. RH incompatibility involves :
    a. Type II reaction b. Type I reaction c. Type IV reaction d. Type V reaction
  42. 42. Which of the following s the intermediate form of non-Hodgkin’s lymphoma :
    • a. Small noncleaved cell b. Diffuse, small cleaved cell
    • c. Lymphoblastic d. Large cell immunoblastic
  43. 43. Reaction found in blood transfusion is :
    • a. Cell-mediated hypersensitivity b. Type III reaction
    • c. Cytotoxic type reaction d. Anaphylactic
  44. 44. Programmed cell death is known as :
    a. Degeneration b. Necrosis c. Apoptosis d. Calcification
  45. 45. Which of the following is the most common tumor of heart :
    • a. leiomyosarcoma b. Rhabdomyosarcoma
    • c. Myxoma d. Fibroma
  46. 46. The most common cause of lungs abscess is :
    a. Aspirated secretions b. Tuberculosis c. Congenital d. Hematogenous
  47. 47. In ulcerative colitis, the site usually involved is :
    a. Rectum b Ileum c. Transverse colon d. Sigmoid colon
  48. 48. In which of the following condition , periglomerular fibrosis and thyroidization of kidney is seen :
    • a. Membranous glomerulonephritis
    • b. Membranoproliferative glomerulonephritis
    • c. Rapidely proliferative glomerulonephritis
    • d. Chronic pyelonephritis
  49. 49. Flea bitten kidney is seen in :
    • a. Chronic pyelonephritis b. Diabetes mellitus
    • c. malignant hypertension d. Diabetes insipidus
    • 50. After which of the following procedure Howell- jolly bodies are seen :
    • a. Pancreatictomy b. Splenectomy c. Cholecystectomy d. Hepatectomy
  50. 51. Which of the following is the best for diagnosing system lupus erythematosus:
    • a. Ribonucleoprotein is less common
    • b. Generic ANA is present in about 95% of cases
    • c. Anti-smith antigen is more common than anti-ds DNA
    • d. Anti-ds DNA is specific
  51. 52.Which of the following organ is not involved in wermer’s syndrome :
    a. Pancreas b. pituitary c. Adrenal d. Parathyroids
  52. 53. In which of the following subendothelial dense deposits corresponding to wire loop under light microscope are seen :
    • a. Sjogren’s suundrome
    • b. Systemic sclerosis
    • c. Malignant hypertension
    • d. Systemic lupus erythematosus
  53. 54. Focal segmental glomerulosclerosis (FSG) does not occur in :
    • a. Hypertension b. Acquired immunodeficiency syndrome
    • c. IGA ;nephropathy d. Sickle cell nephropathy
  54. 55. Lipodystrophy is associated with :
    • a. poststreptococcal glomerulonephritis
    • b. MP glomerulonephritis
    • c. Minimal change glomerrulonephritis
    • d. Membranous glomerrulonephritis
  55. 56.Gandy Gamma bodies are seen in :
    • a. Sickle cell anemia b. Hodgkin’s lymphoma
    • c. G6PD deficiency d. Hereditary spherocytosis
  56. 57. Which of the following is not seen in hypernephroma :
    • a. Hematuria b. Hypertension
    • c. Polycythemia d. Renal vein thrombosis
  57. 58. Which of the following is the most common site of myocardial infarction :
    • a. Inferior wall b. Posterior wall
    • c. Anterolaterral wall d. Interventricular septum
  58. 59. In an inflammation, macrophases are generally derived from
    a. Lymphocytes b. Neutrophills c. Reticuloendothelial cells d. Monocytes
  59. 60. Which of the following is the pathological change that occurs in malignant hypertension :
    • a. Hyaline arteriosclerosis b. Benign nephrosclerosis
    • c. Cystic medial necrosis d. Hyperplastic arteriolitis
  60. 61. In malignant hypertension ,the characteristic finding in kidney is :
    • a. Medial wall hyperplasia b. Hyaline necrosis
    • c. Fibrinoid necrosis d. Microaneurysm
  61. 62. Which of the following is true regarding Epulis :
    • a. it is fibrous dysplasia b. it is the ulcer of lip
    • c. it is osteoid osteoma d. Granulomatous lesion of gingiva
  62. 63. In rabies, most common pathological change is :
    • a. Ventriculities b. Cranial arteritis
    • c. Brainstem encephalitis d. Meningitis
  63. 64. Amyloid is a :
    a. intermediate filament b. Glycoprotein c. Lipoprotein d. Lipid
  64. 65. Normocytic normochromic anemia is not seen in :
    • a. Aplastic anemia b. Chronic renal disease
    • c. Pure red cell aplasia d. thalassemia
  65. 66. myentric ganglion cells are absent in which of the following :
    a. Megacolon b. Achalasia cardia c. Pharyngeal pouch d. Globus pharyngeus
  66. 67. Which of the following is true regarding Berry’s aneurysm ;
    a. it is congenital b. It is neoplastic c. Hypertensive d. mycotic
  67. 68. Which of the following is least commonly involved in berry aneurysm :
    • a. Basilar artery b. Vertebral artery
    • c. Middle cerebral artery d. Anterior communicating artery
  68. 69. Deposition of which of the following element occurs in Wilson’s disease ;
    a. Selenium b. Copper c. Iron d. Lead
  69. 70. Leukocyte alkaline phosphate is not raised in :
    a. CML b. AML c. PNH d. Leukemoid reaction
  70. 71. which of the following is inhibited by aspirin :
    • a. Cyclooxygeenase b. Prostacyclin synthesis
    • c. Phospholipase A d. Lipooxygenase
  71. 72. In which of the following condition, Acute cor pulmonale is seen :
    a. Scoliosis b. Polio c. Massive pulmonary embolism d. Muscular dystrophy
  72. 73. Alpha fetoprotein levels are raised in :
    • a. Hepatocellular carcinoma b. Genital carcinoma
    • c. Lung carcinoma d. Renal tumor
  73. 74. Alpha fetoprotein levels are raised in :
    a. Choriocarcinoma b. Teratoma c. Seminoma d. yolk cell tumor
  74. 75. ARF and hemoptysis is seen in :
    a. Atypical pneumonia b. TB c. Systemic lupus erythematosus d. Goodpasture’s syndrome
  75. 76. Renal papillary necrosis is not seen in :
    a. leukemia b. Analgesic abuse c. Sickle cell anemia d. Diabetes mellitus
  76. 77. the most common change in arterosclerotic vessel is :
    • a. Hemorrhage b. Aneurysm thrombosis
    • c. Sperimposed thrombosis d. Dystrophic calcification
  77. 78. In which of the following,dystrophic calcification is not seen :
    a. Atheromas b. Tubercular lymph nodes c. Cardiac valve d. Kidney
  78. 79. Which of the following is the most common cause of aortic aneurysm :
    a. Syphilis b. Atherosclerosis c. Trauma d. Marfan’s syndrome
  79. 80. The presenting feature of amyloidosis of kidney is :
    a. Hematuria b. Vascular necrosis c. hypertension d. Proteinuria
  80. 81. In muscular dystrophy , the characteristic finding is :
    • a. Inflammatory cell infiltrate
    • b. Muscle necrosis
    • c. Heterogenicity of muscle fiber
    • d. Nuclear proliferation beneath sarcolemma
  81. 82. the liver change in Reye’s syndrome is ;
    a. Cirrhosis b. diffuse steatosis c. Chronic hepatitis d. Acute hepatitis
  82. 83. Which of the following is false regarding IgG:
    • a. J chain is absent
    • b. Cross placenta
    • c. Involved in primary immune response
    • d. increased in multiple myeloma
  83. 84. Which of the following HLA is important in diabetes mellitus :
    a. HLA A13 b. HLA B27 c. HLA B11 d. HLA DR 3DR 4
  84. 85. Which of the following produces prostacyclin :
    a. Lymphocytes b. prostate c. Vascular endothelium d. Platelets
  85. 86. Most common site of pleomorphic adenoma is ;
    • a. Submaxillary gland b. Sublingual gland
    • c. Parotid salivary gland d. Submandibular salivary gland
  86. 87. An elderly male has anemia and splenomegaly. His peripheral blood smear reveals tear drop shaped cells. Bone marrow examination is normal. He is suffering from :
    a. CML b. AML c. iron deficiency anemia d. Idopathic myelofibrosis
  87. 88. Hairy cells leukemia is due to :
    • a. Proloferation of T lymphocytes b. Proliferation of B lymphocytes
    • c. proliferation of macrophage d. Proliferation of myeloid cells
  88. 89. Which of the following has malignant potential :
    • a. Congenital polyposis
    • b. Hyperplastic polyposis
    • c. Familial polyposis
    • d. All of the above
  89. 90. In which of the following amyloid is best seen :
    • a. Zeil nelson test b. pursian blue
    • c. Congo-red with nonpolarized light
    • d. Congo-red with polarized light
  90. 91. Cystic fibrosis is inherited as:
    a. AD b. AR c. X- linked recessive d. X-linked dominant
  91. 92. Gynecomastia is not associated with :
    • a. Ca channel antagonist b. Estrogen therapy
    • c. Carcinoid syndrome d. Chronic liver disease
  92. 93. Which of the following is not seen in anemia of chronic diseases:
    • a. Hypoproliferative marrow morphology
    • b. Decreased serum ferritin level
    • c. Decreased TIBC
    • d. Decreased serum iron level
  93. 94. Which of the following is the primary lymphoma of skin :
    • a. Non-hodgkin’s llymphoma b. Hodgkin’s lymphoma
    • c. Mycosis fungoides d. Granuloma inguinale
  94. 95. CEA is a tumor marker of carcinoma of :
    • a. Gonadal germ cell tumor b. Hepatocellular carcinoma
    • c. Colon d. liver
  95. 96. HLA B 27 associated in :
    • a. SLE b. Narcolepsy
    • c. Ankeylosing spondylitis d. Psoriasis vulgaris
  96. 97. Acid phosphatase is increased in carcinoma of :
    a. Kidney b. Liver c. Lung d. Prostate
  97. 98. Rodent ulcer is…..carcinoma :
    • a. Columnar cell b. Squamous cell
    • c. Basal cell d. Transitional cell
  98. 99. Psammoma bodies are seen in :
    • a. Papillary carcinoma of thyroid b. Carcinoma of ovary
    • c. Both d. None
  99. 100. Prussian blue is used for staining
    a. Bone b. Silica c. Iron store d. Cu store
  100. 101. In marfan’s syndrome, the aortic aneurysm occues in :
    a. Abdominal arota b. Ascending aorta c. Decending aorta d. Arch of aorta
  101. 102. Which of the following is inherited as autosomal dominant trait :
    • a. Hurler’s syndrome b. Huntington’s chorea
    • c. Hunter’s syndrome d. Albinism
  102. 103. Which of the following is a component of Tetralogy of fallot :
    a. VSD b. ASD c. Left ventricular hypertrophy d. Aorta rises form right ventricle
  103. 104. Which of the following is true regarding petuz-jeghers tumor :
    • a. They are neoplastic b. They are hamartomes
    • c. They are neoplastic and inflammatory
    • d. They are inflammatory
  104. 105. In petuz-jeghers syndrome, polyps are seen in which part of GIT:
    a. Small bowel b. Rectum c. Colon d. Stomach
  105. 106. Carcinoid is most common in :
    a. Appendix b. Liver c. Adrenal d. pancreas
  106. 107. Which of the following is false regarding type A fundal gastritis :
    • a. Antibody against intrinsic factor
    • b. Antibody against parietal cells and presence of autoimmunity
    • c. Absent parietal cells
    • d. Low gastric PH
  107. 108. In which of the following,lines of Zahn are seen :
    • a. postmortem clot b. primary platelet clot
    • c. propagated clot d. Glomus tumor
  108. 109. Lines of zain are found in :
    • a. Cardiac vegetation b. Coralline thrombus
    • c. Mural thrombus d. Postmortem clot
  109. 110.. Which of the following pathological change does not occur in alzhelmer’s disease :
    • a. Senile plague b. Shrinkage of caudate nuclei
    • c. Neutofibrillary tangle d. Loss of neurons in cerebral cortex
  110. 111. Platelet counts are normal in :
    • a. Wiskott Aldrich syndrome b. henoch-schonlein purpura
    • c. Immune thrombocytopenia d. Mayer rikitansky syndrome
  111. 112. Which of the following is the primary pleural tumor :
    a. Lipoma b. Mersothelioma c. Myxoma d. Fibroma
  112. 113. Which of the following is not found in biological membrane ;
    a. Cytochrome 450 b. protein c. STeriod receptor d.Lipid
  113. 114. which of the following are not labile cells :
    a. Keratinocytes b. intestinal cells c. Kupffer cells d. Hepatocytes
  114. 115. Laminin is seen in :
    • a. Outer mitochondrial membrane b. Basement membrane
    • c. Inner mitochondrial membrane d. Plasma membrane
  115. 116. Which of the following carcinoma is not associated with DIC:
    a. Liver b. Pancreas c. Prostatic d. Stomach
  116. 117. Keratin is a marker of which of the following :
    a. Rhabdomyosarcoma b. Fibroid c. Carcinoma of cervix d. Neurofibroma
  117. 118. Not a cause of splenomegaly :
    a. Lipid storage disease b. Malaria c. Kala-azar d. None of the above
  118. 119. Which of the following is the most common benign tumor of liver :
    a. Hemangioma b. Nodular fibroma c. hamartoma d. Adenoma
  119. 120.psammoma bodies are seen in :
    • a. Papillary carcinoma of thyroid
    • b. Medullary carcinoma of thyroid
    • c. Follicular carcinoma of thyroid
    • d. Anaplastic carcinoma of thyroid
  120. 121. Which of the following does not cause acute tubular necrosis :
    a. Aesenic b. Mercury c. Tuberculosis d. Lead
  121. 122. Which of the following is the most common site for brain abscess:
    • a. Temporal lobe b. Frontal lobe
    • c. Occipital lobe d. Parietal lobe
  122. 123. In which of the following is the most common site for brain abscess:
    a. TB b. Silicosis c. Lymphoma d. Sarcoidosis
  123. 124.Which of the following is false regarding typhoid ulcer:
    • a. Perforation is les common in children less than 5 years
    • b. Perforation occurs in 3rd week
    • c. Multiple ulcers are found in terminal ileum
    • d. They are placed transversely along the ileum
  124. 125. Regional enteritis commonly involves :
    a. Rectum b. Cecum c. Colon d. Distal ileum and colon
  125. 126. Skip transmural lesion is a characteristic feature of :
    • a. Tuberculous colitis b. Ulcerative colitis
    • c. Regional ileitis d. All of the above
  126. 127. Which of the following is seen in glanzmann’s disease ;
    • a. Platelet dysfunction b. RBC fragility disturbances
    • c. Pan-Cytopenia d. Neutropenia
  127. 128. In inflammation which of the following prostaglandin derivative is not involved :
    • a. Leukotriens b. Prostaglandin E
    • c. Thromboxane A d. Bradykinin
  128. 129. In benign hypertension the most important change in arterioles is :
    • a. Thinning of walls b. Fibrinoid necrosis
    • c. Hyaline arteriosclerosis d. Microaneurysm
  129. 130. In benign hypertension which of the following is the most common pathological findings in kidney :
    • a. Fibrinoid necrosis b. Fibro- fatty plague
    • c. Hyaline arteriosclerosis d. Microaneurysm
  130. 131. Which of the following is the least malignant site of carcinoid tumor:
    a. Appendix b. ileum c. Stomach d. Colon
  131. 132. Which of the following mediator does not promote chemotaxis :
    • a. interleukin 1 b. Tumor necrosis factor
    • c. Serotonin d. Complement factor C5a
  132. 133. In diabetes mellitus, the most common renal lesion is :
    • a. Diffuse thickening of basement membrane
    • b. Nodular glomerulosclerulus
    • c. Fibrin cap in the glomerulus
    • d. Papillary necrosis
  133. 134. In which of the following condition, serum amylase is not increased :
    • a. Strangulated intestinal obstruction
    • b. Acute appendicitis
    • c. Perforated peptic ulcer
    • d. Acute pancreatitis
  134. 135. From which of the following,major basic proteins are derived ;
    a. Mast cells b. Basophils c. Eosinophils d. Neutrophils
  135. 136. Which of the following has best prognosis in hodgkin’s disease ;
    • a. Lymphocyte depleted b. Lymphocyte predominance
    • c. Mixed cellularity d. Nodular sclerosis
  136. 137. All of the following cause amyloidosis except :
    • a. Leprosy b. Chronic bronchitis
    • c. Tuberculosis d. Granulomatous ileitis
  137. 138. which of the following is not of endothelial origin :
    a. Glomus tumor b. Hemangioma c. Chordoma d. Lymphangioma
  138. 139. Which of the following is a vitamin k dependent factor ;
    a. IV b. II c. III d. VI
  139. 140. Which of the following is not a predisposing factor for carcinoma esophagus :
    • a. Chronic achalasia b. benzene therapy
    • c. Tylosis Palmaris d. plummer-Vinson syndrome
  140. 141. Which of the following is responsible for green house effect:
    a. Chlorofluorocarbons b. Nitrous oxide c. Methane d. All of the above
  141. 142. Which of the following is not a clinical feature of minimal change glomerulonephritis :
    a. Fever b. Hematuria c. Hypertension d. Selective proteinuria
  142. 143. For myocardial infarction, the average time required for complete healing is :
    a. 3 weeks b. 15 weeks c. 7 Weeks d. 9 Weeks
  143. 144. In nonsmokers the most common type if carcinoma lung is :
    a. Squamous cell b. Small cell c. Alveolar cell d. Adenocarcinoma
  144. 145. Which of the following is the most common premalignant condition of oral carcinoma :
    a. Lichen planus b. Leukoplakia c. Erythroplakia d. Fibrosis
  145. 146. which of the following is not caused by zenc deficiency :
    • a. Sexual infantilism b. Growth retardation
    • c. Immunological disturbances d. Cardiiomyopathy
  146. 147. Toxic megacolon is seen in :
    a. Whipple’s disease b. Crohn’s disease c. Ulcerative colitis d. Reiter’s disease
  147. 148. In which of the following condition ,hypertriglyceridemia is seen :
    • a. Abetalipoproteinemia b. Dysbetalipoproteinemia
    • c. LDL receptor defect d. All of the above
  148. 149. Which of the following is true regarding idiopathic thrombocytopenic purpura :
    • a. It is due to decreased megakaryocytes
    • b. It is due to antibody against platelets
    • c. It is due to increased intravascular platelet consumption
    • d. It is due to decreased platelet synthesis
  149. 150. A child has minimal change disease which is well controlled by steroids, the most likely finding on light microscopy is :
    • a. Severage mesangial hypercellularity
    • b. Fusion of foot process
    • c. No finding
    • d. Hypercellular glomeruli
  150. 151. Characteristic feature of minimal change disease is :
    • a. Thickening of glomerular basement membrane
    • b. Splitting of glomerular basement membrane
    • c. IgA deposition in crescent form
    • d. Loss of podocytes on electron microscope while normal in light microscope
  151. 152. Which of the following gene prevents apoptosis :
    a. bax b. Bad c. p53 d. bcl2
  152. 153. Group b lymphocyte belongs to CD….
    a. 19 b. 57 c. 15 d. 29
  153. 154. Gallbladder adenomyoma are always situated in ;
    a. Hartman’s pouch b. Fundus c. Neck d. Bile duct
  154. 155. Prognosis of soft tissue sarcoma depends upon :
    • a. Grading of tumor b. Site of tumor
    • c. Size of tumor d. Lymphadenopathy
  155. 156. Which of the following is true regarding sideroblastic anemia :
    • a. X- linked disorder
    • b. Y- linked disorder
    • c. Autosomal recessive disorder
    • d. Autosomal dominant disorder
  156. 157. Which of the following is the most common site of epithelioid leiomyoma :
    a. Colon b. Stomach c. ileum d. Rectum
  157. 158. In CLL most common cell type is :
    a. Mixed type b. T lymphocyte c. B lymphocyte d. Null cell
  158. 159. In which of the following condition , there is linear IgG deposition in glomerilar basement membrane:
    • a. Chronic renal failure b. Shunt nephritis
    • c. Nephrotic syndrome d. Goodpasture’s syndrome
  159. 160. Homer Wright rosettes are seen in :
    a. Glioma b. pineal blastoma c. Astrocytoma d. medulloblastoma
  160. 161. Violin string sign in perihepatitis is now mosty due to :
    a. Pseudomonas b. Gonococcus c. Chlamydia d.Proteus
  161. 162. Most common carcinoma of lung is :
    • a. Small cell carcinoma
    • b. Squamous cell carcinoma
    • c. Adenocarcinoma
    • d. Bronchioloaiveolar carcinoma
  162. 163. Half –life of neutrophill is :
    a. 6-8 days b. 2-3 days c. 6 hours d. 24 hours
  163. 164. Which of the following is present in platelets :
    a. Prostaglandins b. . Serotonin c. Gamma amino butyric acid d. Acetylcholine
  164. 165. Which of the following is not an example of type III hypersensitivity :
    a. Tuberculosis b. Arthus reaction c. Serum sickness d. Glomerulonephritis
  165. 166. Pheochromocytoma originates from ;
  166. a. Neurons b. Mesenchymal cells
    c. Chromaffin cells d. Ganglion cells
  167. 167. Thrombocytopenia is not associated with :
    • a. Immunogenic thrombocytopenia
    • b. Thrombocytoopenic purpura
    • c. Henoch-schonlein purpura
    • d. Hemolytic syndrome
  168. 168. Tumor associated with polycythemia vera is :
    • a. Chordoma b. Cerebellar hemangioblastoma
    • c. Gastric tumor d. Soft tissue sarcoma
  169. 169. which of the following is commonly affected in syphilis:
    • a. proximal aorta b. Descending aorta
    • c. Ascending aorta d. Abdominal aorta
  170. 170. Tuberculosis bacillus cannot be phagocytised because of :
    • a. Peritrichate cilia b. Muramyl di- peptidase
    • c. Cord factor d. Wax D
  171. 171. which of the following preservative is used for storing blood for transfusion :
    • a. Citrate + glucose b. EDTA
    • c. CPD –A d. heparin + dextrose
  172. 172. Mycosis fungoides is :
    • a. Cutaneous B cell lymphoma b. Cutaneous T cell lymphoma
    • c. Hairy cell leukemia d. Hodglin’s lymphoma
  173. 173. Carcinoids do not produce :
    a. Histamine b. Serotonin c. Bradykinin d. 5 Hydroxy-trytophan
  174. 174. Which of the following is the frequent site of extra-adrenal pheochromocytoma :
    • a. posterior mediastinum b. Urinary bladder
    • c. Anal canal d. Organ of zuckerkandi
  175. 175. in pheochromocytoma, malignancy is indicated by :
    • a. Mitotic figures b. Giant cell predominant
    • c. Nuclear pleomorphism d. Vascular invasion
  176. 176. in which of he following, APUD cells are seen :
    • a. Bronchial carcinoid b. Hepatic adenoma
    • c. Villous adenoma d. Bronchial adenoma
  177. 177. Which of the following is true regarding langerhans’ cells :
    • a. They are phagocytic b. Chronic infection
    • c. They are of autoimmune nature d. They are of antigen presenting nature
  178. 178. Which of the following Is false regarding hereditary spherocytosis :
    • a. It is autosomal dominant
    • b. Splenomegly
    • c. Hemolytic crisis is the usual presentation
    • d. Normal or decreased MCV
  179. 179. liver cirrhosis is not seen in :
    • a. Chlorpromazne toxicity b. Chronic alcoholism
    • c. Hemochromatosis d. Alpha, Antitrypsin deficiency
  180. 180. Not associated with MEN type 2A ;
    • a. Medullary carcinoma of thyroid
    • b. Pituitary adenoma
    • c. Parathyroid hyperplasia
    • d. Pheochromocytoma
  181. 181. Which of the following causes lacunar infarcts :
    • a. Thrombosis of basilica vein
    • b. Lipohyalinosis of penetrating arteries
    • c. Middle carotid artery involvement
    • d. Emboli to cerebral cortex
  182. 182. A young man in his twenties presented with mass involving the duodeojejunal flexure and invading the renal papilla. Histopathological examination revealed lymphoma. Which of the following is true :
    • a. Stage III E b. stage IV E c. stage II E
    • d. Staging will not be done until bone marrow examination is done
  183. 183. RBC casts in urine analysis, most likely source is :
    a. kidney b. bladder c. Ureter d. Urethra
  184. 184. which of the following tissue is most sensitive and vulnerable to lack of oxygen
    a. Brain b. Heart c. Liver d. Kidney
  185. 185. Cloudly swelling is because of :
    • a. Lysozyme degeneration
    • b. Intracellular accumulation of glycogen
    • c. Intracellular accumulation of fat
    • d. Intracellular accumulation of water
  186. 186. In which of the following disease PAS positive glycoprotein containing macrophages with in the lamina propria of intestinal mucosa is found :
    a. Whipple’s disease b. Crohn’s disease c. Tropical sprue d. Celiac sprue
  187. 187. Reversible cell injury is not characterized by :
    a. Karyorrhexis b. Fat droplets c. Cloudy swelling d. Hydrophobic degeneration
  188. 188. Which of the following is true regarding irreversible injury in cell:
    • a. Swelling b. Mitotic figure
    • c. Deposition of calcium ions in mitochondria d. Ribosomal detachment
  189. 189. In cyclooxygenase pathway which of the following is not produced :
    a. TXA2 b. PGE2 c. PGI2 d. Leukotriens
  190. 190. All of the following are carcinogenic except :
    a. Alpha- toxin B1 b. Coal tars c. Benzidine d. Vitamin A
  191. 191. Splenic infarct is not seen in :
    a. CML b. SABE c. Sickle cell anemia d. Rheumatoid arthritis
  192. 192. AL amyloid originates from :
    a. Plasma cells b. Lymphocytes c. RBC d. Reticuloendothelial origin
  193. 193. Macrocytosis is not seen in :
    • a. B deficiency b. Folic acid deficiency
    • c. Thalassemia major d. Hypothyroidism
  194. 194. In which of the following condition ,lipoprotein X is raised :
    • a. Indian childhood cirrhosis b. Hypercholesterolemia
    • c. Primary biliary cirrhosis d. Alchoholic cirrhosis
  195. 195. Which of the following is the earliest response to iron therapy :
    • a. increased PCV b. Increase in hemoglobin
    • c. Increased neutrophills d. REticulocytosis
  196. 196. Which of the following is the correct ration of CSF and blood sugar:
    • a. 1/4th of blood sugar b. 3/4th of blood sugar
    • c. 2/3rd of blood sugar d. both are equal
  197. 197. Antineutrophill cytoplasmic antibodies are not associated with :
    • a. Henouch – schonlein purpura b. Microscope PAN
    • c. Churg strauss syndrome d. Wegner’s granulomatosis
  198. 198. Which of the following is not seen in amyloid kidney :
    a. Azotemia b. Normal size kidney c. Hypertension d. Massive proteinuria
  199. 199. A patient has increased red cell protoporphyrin . his MCV is 60, hemoglobin 6.5gm% and MCH 15/G. Most probable diagnosis is :
    a. Megaloblastic anemia b. Iron deficiency anemia c. Porphyria d. Thalassemia
  200. 200. In primary amyloidosis, the major fibril protein is:
    a. AL b. Procalcitonin c. Transthyretin d. AA
  201. 201. Anti-smith antibodies are found in :
    a. Rheumatoid arthritis b. SLE c. Systematic sclerosis d. polymyositis
  202. 202. Wire – loop lesions are seen in :
    a. Systemic sclerosis b. Sjogren’s syndrome c. SLE d. Steven s-johnson syndrome
  203. 203.kimmelstiel –wilson lesions are seen in :
    • a. hypertensive nephropathy b. PSGN
    • c. Diabetic nephropathy d. HSP
  204. 204. Which of the following is an essential component of granuloma ?
    a. Epithelioid cell b. Giant cell c. Tuberculoma d. Globi
  205. 205. A female presents with hilar lylmphadenopathy, pulmonary symptoms and skin nodules. The tuberculin test shows 5 mm induration. Which of the following is most likely in skin biopsy ?
    • a. Caseating granuloma b. Non-Caseating granuloma
    • c. Vasculities d. Malignant cells
  206. 206. Lacunar cells are found in which of the following types of Hodgkin’s disease ?
    • a. Nodular sclerosis b. Lymphocyte deficient
    • c. Lymphocyte predominant d. mixed cellularity
  207. 207. CEA is elevated in which of the following malignancies ?
    • a. Ling, breast, testis
    • b. Lung, colon, pancreas
    • c. Breast ,colon, testis
    • d. Thyroid ,breast ,lung
  208. 208. Which of the following carcinomas does not have carcinoembryonic antigen ?
    • a. Bronchogenic carcinoma
    • b. Cervical carcinoma
    • c. Carcinoma breast
    • d. Pancreatic carcinoma
  209. 209. All of the following are associated with increased risk of colonic carcinoma except
    • a. peutz-hjeghers syndrome
    • b. villous adenomas
    • c. polyposis coli
    • d. ulcerative colitis
  210. 210. In polycystic kidney disease, cysts are not found in ?
    a. liver b. Lung c. kidney d. Brain
  211. 211. Polycystic kidney is most frequently associated with :
    a. Liver cysts b. Cyst of pancreas c. Lung cyst d. Brain cyst
  212. 212. ‘Tram track’ appearance is seen in which of the following nephropathies
    • a. Focal segmental b. Mesangioproliferative
    • c. Membranoproliferative d. Membranous
  213. 213. All of the following are risk factors for deep vein thrombosis(DVT) except :
    • a. Duration of surgery more than thirty minutes b. obesity
    • c. Age less than forty years
    • d. use of the estrogen-progesterone contraceptive pills
  214. 214. All of the following conditions may predispose to pulmonary embolism except:
    • a. Protein S deficiency b. Malignancy
    • c. Obesity d. Progesterone therapy
  215. 215. Which of the following is the most common location of hypertension hemorrhage ?
    a. Pons b. Thalamus c. Putamen/external capsule d. Cerebellum
  216. 216. Which of the following is the most common location of hypertensive hemorrhage ?
    • a. Pons b. Thalamus
    • c. Putamen/external capsule d. Subcortical white matter
  217. 217. The most common site for hypertensive intracerebral bleed is :
    a. Putamen b. Cerebellum c. pons d. Mildbrain
  218. 218. Most common site for hypertensive intracranial bleeding is :
    a. Temporal lobe b. putamen c. Cerebellum d. Thalamus
  219. 219. eggshell calcification is seen in :
    a. Sarcoidosis b. Silicosis c. Asbestosis d. Berylliosis
  220. 220. Leuloerthroblastic picture may be seen in all of the following except :
    • a. Myelofibrosis b. Metastatic carcinoma
    • c. Gaucher’s disease d. Thalassemia
  221. 221. Which of the following is false regarding leukoerythroblastosis ?
    • a. it is characteristic of myelophthisis anemia
    • b. A variety of misshaped erythrocytes along with increased WBC are senn
    • c. Infiltration of bone marrow with tumor, fibrosis of granulomas
    • d. None of the above
  222. 222. head and neck cancer is associated with which gene ?
    a. p43 b. p53 c. p63 d. p73
  223. 223. A girl is having breast carcinoma. Her mother died from ovarian carcinoma. You will ask for examination of which gene:
    a. p53 oncogene b. BRCA-2 gene c.Her-2 neu gene d. c-myc gene
  224. 224. Calcitonin is a tumor marker in :
    • a. papillary thyroid carcinoma b. Medullary thyroid carcinoma
    • c. Pancreatic carcinoma d. Adenocarcinoma thyroid
  225. 225. Medullary carcinoma aof the thyroid is associated with which of the following syndrome ?
    a. MEN I b. MEN II c. Fraumeni syndrome d. Hashimoto’s thyroiditis
  226. 226. Calcitonin is a marker of
    • a. papillary carcinoma of thyroid
    • b. medullary carcinoma of thyroid
    • c. Anaplastic carcinoma of thyroid
    • d. Adenocarcinoma of thyroid
  227. 227. Lardaceous spleen is found in :
    • a. Hodgkin’s lymphoma b. CML
    • c. Malaria d. Amyloidosis
  228. 228. Lardaceous spleen is seen due to deposition of amyloid in ;
    • a. sinusoids of red pulp b. white pulp
    • c. Pencillary artery d. Splenic trabeculae
  229. 229. Aschoff bodies in rheumatic heart disease show all the following features except:
    • a. Anitschkow cells b. Epithelioid cells
    • c. Giant cells d. Fibrinoid necrosis
  230. 230. Which of the following is not a content of Aschoff nodule ?
    • a. Fibrinoid necrosis b. Aschoff cells
    • c. Epithelioid cells d. Aschoff giant cells
  231. 231. In rheumatic fever, which of the following type of pericarditis is most common?
    a. Serofibrinous b. Seropurulent c. Serous d. Hemorrhagic
  232. 232.In rheumatic fever the exudate is
    a. Purulent b. Myxomatous c. Fibrinous d. Serous
  233. 233. Liver biopsy is normal in :
    • a. Dubin-Johnson syndrome b. Gilbert’s syndrome
    • c. Hemochromatosis d. Wilson’s disease
  234. 234. Accumulation of spingomyelin in phagocytic cells is a feature of :
    • a. Gaucher’s disease b. Niemann-Pick disease
    • c. Tay-Sachs disease d. down’s syndrome
  235. 235. Phagocytosis in brain is done by
    • a. Microglia b. Oligodendrocytes
    • c. Fibrous astrocytes d. Protoplasmic astrocytes
  236. 236. In malignant hypertension, the characteristic pathological change is :
    • a. Fibro-elastic hyperplasia b. Diffuse tubular atrophy
    • c. Necrotizing arteriolitis d. Hyaline arteriosclerosis
  237. 237. The m4 stage in AML is associated with the presence of :
    a. Megaloblasts b. Myeloblasts c. Myelomonocytes d. Promyelocytes
  238. 238. In which of the following DIC is seen ?
    a. ML type M1 b. AML type M2 c. ALL d. AML type M3
  239. 239. In which of the following condition,anti-glomerular basement membrane antibodies with necrotizing hemorrhagic interstitial pneumonitis is seen
    • a. Goodpasture’s syndrome
    • b. Membranous glomerulonephritis
    • c. Post-streptococcal glomerulonephritis
    • d. Membranoproliferative glomerulonephritis
  240. 240. In which of the following condition ,there is linear deposition of IgG along the basement membrane?
    • a.Goodpasture’s syndrome b. Nephrotic syndrome
    • c. systemic lupus erythematous d. RPGN
  241. 241. In cirrhosis, the splenomegaly is :
    • a. Inflammatory b. Phagocytic
    • c. Degenerative d. Congestive
  242. 242. Centrilobular necrosis is not seen in :
    • a. Hemorrhagic shock b. Halothane
    • c. Yellow fever d. chronic venous congestion
  243. 243. Which of the following is the most common type of cell death due to sudden cessation of blood supply ?
    a. Apoptosis b. Coagulation necrosis c. Cessation necrosis d. Apoptosis
  244. 244. In Philadelphia chromosome translocation seen is:
    a. 14-18 b. 9-22 c. 8-14 d. 11-14
  245. 245. CML is associated with all of the following except :
    • a. increased platelet count b. increased vitamin B12 levels
    • c. Increased leukocyte count d. increased leukocyte alkaline phosphatase
  246. 246. Gluten-sensitive enteropathy is most strongly associated with
    a. HLA-DQ2 b. HLA-DQ 4 c. HLA-DQ3 d. Blood group ‘B’
  247. 247. Abelson oncogene is associated with which of the following leukemia ;
    • a. Acute myeloid leukemia b. Acute lymphocytic leukemia
    • c. Chronic myeloid leukemia d. Chronic lymphocytic leukemia
  248. 248. In CML the translocation occurring is :
    • a. ABL of chromosome 9 to BCR of chromosome 21
    • b. ABL of chromosome 9 to BCR of chromosome 22
    • c. BCR of chromosome 9 to ABL of chromosome 21
    • d. BCR of chromosome 9 to ABL of chromosome 22
  249. 249. M4 in the classification of AML denotes which of the following stages;
    a. Promyelocytic b. Monocytic c. Myelomonocytic d. Megakaryocytic
  250. 250. Von willebrand’s disease is transmitted as:
    • a. Autosomal recessive b. Autosomal dominant
    • c. X-linked recessive d. Y-llinked recessive
  251. 251. X-linked dominant inheritance pattern is seen in:
    • a. polycystic kidney disease b. Vitamin D resistant rickets
    • c. Cystic fibrosis d. Von willebrand’s disease
  252. 252. Myotonic dystrophy is inherited as:
    • a. Autosomal dominant b. X-linked recessive
    • c. Autosomal recessive d. Multifactorial
  253. 253. In multiple myeloma, lytic lesions are most common at :
    a. Clavicle b. Vertebral column c. Femur d. Pelvis
  254. 254. Late manifestation of multiple myeloma is :
    • a. Normal alkaline phosphatase b. Renal failure
    • c. Osteolytic lesion d. M-Sike
  255. 255. a renal biopsy from a 56 year old woman with progressive renal failure for the past 3 years shows glomerular and vascular deposition of pink lamorphous material. It shows apple- green birefringence under polarized light after congo red staining. These deposits are positive for lambda light chains. The person is most likely to suffer from :
    • a. Rheumatoid arthritis b. Tuberculosis
    • c. Systemic lupus erythematosus d. multiple myeloma
  256. 256. in which of the following condition, alkaline phosphate level is not increased :
    • a. Multiple myeloma b. Paget’s disease
    • c. Osteomalacia d. Hyperparathyroidism
  257. 257. In multiple nmyeloma the amyloid protein is :
    a. AL b. AA c. SAA d. b2M
  258. 258. Increased expression of erb-2 gene is associated with ?
    a. Breast cancer b. prostate cancer c. Lung cancer d. Liver cancer
  259. 259. All the statements about lactoferrin are true , except :
    • a. it is present in secondary granules of neutrophil
    • b. it is present inexocrine secretions of body
    • c. it has great affinity for iron
    • d. it transports iron ‘for’erythropoiesis
  260. 260. Serum total lactate dehydrogenase level will not be raised in :
    • a. Musclce crush injury b. Stroke
    • c. Myocardial infarction d. Hemolysis
  261. 261. HTLV-1 is responsible for
    • a. Acquired immunodeficiency syndrome
    • b. Tropical spastic paraparresis
    • c. T cell leukemia
    • d. B cell leukemia
  262. 262. Pseudopolyposis are seen in :
    • a. Ulcerative colitis b. Cohn’s disease
    • c. Coeliac sprue d. Whipple’s disease
  263. 263. Most common cause of SVC obstruction is
    • a. Bronchogenic carcinoma b. Fibrosis of SVC
    • c. Pericardial fibrosis d. Hepatocellular carcinoma
  264. 264. Which of the following is the most common cause of SVC obstruction ?
    • a. Teratoma b. Mediastinal lymphoma
    • c. Extrinsic compression d. Thrombosis
  265. 265. Carcinoma of lung, which presents as SVC obstruction is
    • a. Large cell carcinoma b. Anaplastic cell carcinoma
    • c. Squamous cell carcinoma d. Oat cell carcinoma
  266. 266. Mechanism of type II hypersensitivity reaction is ;
    • a. Immune complex disease b. Antigen against tissue
    • c. IgE mediated d. Antibody directed to tissue antigen
  267. 267. Which of the following are involved in ‘delayed’ hypersensitivity ?
    a. Lymphocytes b. Eosinophils c. Neutrophils d. Monocytes
  268. 268. Which of the following is a type IV hypersensitivity reaction ?
    • a. Serum sickness b. Arthus reaction
    • c. Schwartzman reaction d. Granulomatous reaction
  269. 269. A 40 year old man has a chronic cough with fever for several months.the chest radiograph reveals diffuse reticulonodular pattern . microscopically intransbronchial biopsy there are focal areas of inflammation containing epithelioid cell granuloma, langhans giant cells and lymphocytes . these findings are typical for which of the following type of hypersensitivity immunologic responses?
    a. Type I b. Type II c. Type III d. Type IV
  270. 270. Not an example of delayed hypersensitivity reaction :
    • a. Tissue graft reaction b. Tubercular granuloma
    • c. Arthus reaction d. contact dermatitis
  271. 271. Which of the following statements is not correct ?
    • a. Transfusion reaction – type II hypersensitivity reaction
    • b. Allograft rejection – type IV hypersensitivity reaction
    • c. Serum sickness- type II hypersensitivity reaction
    • d. Theobald smith phenomenon- type I hypersensitivity reaction
  272. 272. A girl developed redness and swelling of ear lobes after wearing some earrings, this is an example of which of the following type of hypersensitivity ?
    • a. Cell mediated hypersensitivity
    • b. Immune complex disease
    • c. Cytotoxic hypersensitivity
    • d. Immediate hypersensitivity
  273. 273. In post- streptococcal glomerulonephritis the type of hypersensitivity includes:
    .a. Type IV b. Type III c. Type II d. Type I
  274. 274. Which of the following is an example of immediate hypersensitivity /
    a. lepromin test b. Casoni’s test c. Serum sickness d. PPD
  275. 275. Which of the following is the type I reaction ?
    a. Sick test b. Mantoux test c. Casoni’s test d. Fri test
  276. 276. Which of the following is an example of type I hypersensitivity ?
    a. Lepromin test b. Schick test c. CAsoni’s test d. Mantoux test
  277. 277. HUS is characterized by all except :
    • a. usually follows gastroenteritis
    • b. Verotoxin initiated endothelial injury
    • c. Presents with ARF
    • d. P.S shows evidence of DIC
  278. 278. Which of the following is the most common carcinoma of breast?
    • a. Sarcoma phyllodes b. Lobular carcinoma
    • c. Infiltrative ductal carcinoma d. Colloidal carcinoma
  279. 279. In young female, most common type of breast carcinoma is :
    a. Medullary b. Papillary c. Infiltrating ductal d. Lobular
  280. 280. A 13 year old boy is referred for evaluation of nocturnal enuresis and short stature. His blood pressure is normal. The hemoglobin level is 8g/dl,urea 112 mg/ml, creatinine 6mg/dl,sodium 119meq/l, potassium 4mE/l ,calcium 7 mg/dl,phosphate 300U/L. urinalysis shows bilateral small kidneys small kidney sand the micturating cystourethrogram is normal. The most likely diagnosis is ;
    • a. Alport’s syndrome b. medullary sponge kidney
    • c. Chronic glonerulonephritis d. Nephronophthisis
  281. 281. upper GI endoscopy and biopsy from lower esophagus in a 48 years old lady with chronic heart burn shows presence of columnar epithelium with goblet cells. The feature is most likely consistent with :
    a. Dysplasia b. Hyperplasia c. Carcinoma in situ d. Metaplasia
  282. 282. Which of the following is different between natural killer cells and cytoxic T cells?
    • a. Natural killer cells contain azurophilic cytoplasmic granulocyte
    • b. Cytotoxic cells lyse IhG coated target cells
    • c. NK cells have CD4
    • d. Interferons decrease NK cell activity
  283. 283. Which of the following is false regarding natural killer cells ?
    • a. It performs function similar to macrophages
    • b. It is activated by IL3
    • c. CD3 receptors are present
    • d. It is a variant of large lymphocyte
  284. 284. Which of the following is common to natural killer cells and cytotoxic T cells?
    • a. HLA class II is involved
    • b. Antibody is required for cytotoxicity
    • c. Antiviral action
    • d. Antibody production
  285. 285. Which of the following is pan –T- lymphocyte marker ?
    a. CD 2 b. CD 3 c. CD 19 d. CD 25
  286. 286. Anti – Fibrillarin antibodies are seen in :
    • a. Rheumatoid arthritis b. systemic lupus erythematosus
    • c. Mixed connective tissue disease d. Systemic sclerosis
  287. 287. HIV- associate nephropathy is characterized by all of the following except :
    • a. Membranoproliferative glomerrulonephritis
    • b. More common in blacks
    • c. Severe nephritic syndrome
    • d. Rapid progression to end stage renal disease
  288. 288. Rapillary necrosis is seen in all the following except:
    • a. SLE b. Vascular thrombosis
    • c. Diabetes d. NSAIDs induced nephrotoxicity
  289. 289. Which of the following is the most common cause if renal papillary necrosis ?
    • a. Sickle cell anemia b. Chronic pyelonephritis
    • c. Analgestic nephropathy d. NIDDM
  290. 290.The correct sequence of cell cycle is :
    • a. GO-G1-S-G2-M b. GO-G1-G2-S-M
    • c. GO-M-G2-S-G1 d. GO-G1-S-M-G2
  291. 291. In post- streptococcal glomerrulonephritis, crescents are:
    • a. Macrophages b. Epithelial, mesangial and macrophages
    • c. Mesangial cells d. Epithelial cells
  292. 292. In hemolytic anemia which of the following cell is specific for microangiopathy
    a. Elliptocytes b. Schistocytes c. Spherocytes d. Fragmented RBCs
  293. 293.In which of the following disease cylindrical dilation of renal tubules occur?
    • a. Lipoid nephrosis b. Wilms’ tumor
    • c. Medullary cystic disease d. Polycystic kidney
  294. 294.In hepatitis B,membranous glomerrulopathy is because of ;
    a. HBeAG b. HBsAG c. HBcAG d. anti-HBsAG
  295. 295. A patient has lung carcinoma with nephritic syndrome. The nephritic syndrome is of which of the following types?
    • A. Mesangioproliferative type
    • b. Membranous type
    • c. Minimal change type
    • d. Mesangial type
  296. 296. in which of the following c-ANAC is seen ?
    a. RPGN b. PAN c. Wegener’s granulomatosis d. SLE
  297. 297. Adenosine deaminase deficiency is associated with :
    • a. Nezelof syndrome
    • b. Chronic granulomatous disease
    • c. Common variable immunodeficiency
    • d. Severe combined immunodeficiency
  298. 298. In which of the following carcinomas of lung, there is ectopic productin of ACTH:
    a. Anaplastic b. Small cell c. Adenocarcinoma d. Squamous cell
  299. 299. Most sensitive and specific test for diagnosis of iron deficiency is :
    • a. serum iron levels b. Serum ferritin levels
    • c. Serum transferring receptor population
    • d. Transferring saturation
  300. 300. Ferritin is decreased in :
    • a. sideroblastic anemia b. Beta thalassemia
    • c. iron deficiency anemia d. Anemia of chronic infection
  301. 301. Which of the following is the best test for assessing iron status?
    a. Hemoglobin b. Serum iron c. Transferrin d. Ferritin
  302. 302. Which of the following is due to ‘point’ mutation ?
    a. NIDDM b. porphyria c. color blindness d. Sickle cell anemia
  303. 303. Which of the following is true regarding sickle cell anemia ?
    • a. it is due to presence of structurally abnormal hemoglobin
    • b. it is due to red cell enzyme deficiency
    • c. It is due to unknown multiple mechanism
    • d. It is due to disturbance of proliferation and differentiations of stem cell
  304. 304.Which of the following cell types is most common in islets of langerhans of pancreas?
    a. Beta cells b. Alpha cells c. Delta cells d. F cells
  305. 305. In nephritic syndrome which of the following is increased ?
    a. Albumin b. Ceruloplasmin c. Fibrinogen d. Transferrin
  306. 306. The presenting feature of cerebral amyloid angiopathy is :
    a. Lacunar infarct b. Hemorrhage c. Lobar infarct d. Dementia
  307. 307. All of the following diseases are transmitted in autosomal recessive pattern except :
    • a. Hurler’s syndrome b. Hunter’s syndrome
    • c. Alkatopuria d. Gaucher’s disease
  308. 308. Which of the following diseases are transmitted in autosomal recessive pattern except :
    a. Proteoglycan b. Fibronectin c. Albumin d. Collagen
  309. 309. Which of the following type of nephritic syndrome does not respond well to steroid therapy ?
    • a. lupus nephritis
    • b. Focal segmental glomerulosclerosis
    • c. membranous glomerulonephritis
    • d. Membranoproliferative glomerulonephritis
  310. 310. maximum endocapillary proliferation is seen in which of the following nephropathies?
    • a. Focal segmentation glomerulonephirits
    • b. Mesangioproliferative
    • c. Membranoproliferative
    • d. post-streptococcal
  311. 311. Which of the following is not a characteristic features of anemia of chronic diseases/
    • a. Decreased serum ferritin b. Decreased sesrum iron
    • c. Decreased TIBC d. Increased macrophages in marrow
  312. 312. Antinuutrophil cytoplasmic antibody ( ANCA) is most sensitive and specific marker for which of the following
    • a. Henoch- schonlein purpura b. SLE
    • c. Idiopathic cresentic glomerulonephritis d. PAN
  313. 313. All of the following can cause of megakaryocytic thrombocytopenia, except :
    • a. Idiopathic thrombocytopenic purpura b. SLE
    • c. Aplastic anemia d. DIC
  314. 314. All of the following diseases cause massive splenomegaly, except:
    • a. Malaria b. Kala azar
    • c. Lymphoblastic leukemia d. Idiopathic myelofibrosis
  315. 315. Which one of the following soft tissue sarcomas frequently mestastasises to lymph nodes:
    • a. Fibrosarcoma b. osteosarcoma
    • c. Embryonal rhabdomyosarcoma d. Alveolar soft part sarcoma
  316. 316. Troponin T is a marker of ;
    a. Renal disease b. Muscular dystrophy c. Cirrhosis of liver d. MI
  317. 317. Calcification of soft tissue with out any disturbance of calcium metabolism is called
    • a. Ionotropic calcification b. monotropic calcification
    • c. Dystrophic calcification d. Calcium induced calcification
  318. 318. A baby girl with ambiguous genitails is found to have 21 hydroxylase deficiency of the salt wasting type . which of the following karyotypes would you except to find;
    a. 46XX b. 46XY c.47XXY d. 47 XYY
  319. 319. Virchow’s triad includes all, except:
    • a. Venous stasis b. Injury to veins
    • c. Blood hypercoagulability d. Venous thrombosis
  320. 320. Most common cause of subarachnoid hemorrhage is :
    • a. Hypertension b. Aneurysm
    • c. Arteriovenous malformations d. Bleeding disorders
  321. 321. Subdural hematoma most commonly results from :
    • a. Rupture of intracranial aneurysm
    • b. Rupture of cerebral AVM
    • c. Injury of cortical bridging veins
    • d. Hemophilia
  322. 322. Which of the following tumors have an increased elevation of placental alkaline phosphates in the serum as well as a positive immunohistochemical staining for placental alkaline phosphates ?
    • a. Seminoma
    • b. Hepatoblastoma
    • c. Hepatocellular carcinoma
    • d. Periopherial neuroectodermal tumor
  323. 323. Lung biopsy in acute hepatitis due to hepatitis B virus is likely to show all of the following, except :
    • a. Balloning change of hepatocytes
    • b. Ground glass hepatocytes
    • c. Focal or spotty necrosis
    • d. Acidophill bodies
  324. 324. A 20 years old female, asymptomatic,not requiring blood transfusion, presents with hemoglobin 13.0 G%. Her Hb-F level are 95%, HBA 2 is 1.5 %. Which of the following is the most likely diagnosis?
    • a. Hereditary persistence of fetal hemoglobin
    • b. Beta homozygous thalassemia
    • c. Thalassemia intermedia
    • d. Beta heterozygous thalassemia
  325. 325. HIV associated nephropathy is a type of :
    • a. Membranous glomeruonephritis
    • b. Immunotactoid glomerulopathy
    • c. Collapsing glomerulopathy
    • d. Fibrillary glomerulopathy
  326. 326. Endoscopic biopsy from a case of helicpopbater pylori related duodenal ulcer is most likely to reveal:
    • a. Antral predominant gastritis
    • b. Multifocal atrophic gastritis
    • c. Acute erosive gastritis
    • d. Gastric atrophy
  327. 327. which of the following is detected by the antigen detection test used for diagnosis of plasmodium falciparum malaria?
    • a. Circum sporozoite protein b.Mertozoite surface antigen
    • c. Histidine rich protein I d. Histidine rich protein II
  328. 328. An example of a tumor suppressor gene is :
    a. myc b. fos c. ras d. RB
  329. 329. which of the following conditions commonly predisposes to colonic carcinoma?
    • a. Ulcerative colitis b. Crohn’s disease
    • c. Diverticular disease d. Ischemic colitis
  330. 330. In von Hippel-Lindau disease, the retinal vascular tumors are often associated with intracranial hemangioblastoma. Which of the following region is associated with with such vascular abnormalities in this syndrome?
    a. Optic radiation b. Optic tract c. Cerebellum d. Pulvinar
  331. 331. A simple bacterial test for mutagenic carcinogens is :
    a. Ames test b. Redox test c. Bacteriophage d. Gene splicing
  332. 332. Which of the following is the most common location of hypertensive bleed in the brain ?
    a. Putamen b. Pons c. Ventricles d. Lobar white matter
  333. 333. Which type of amyloidosis is caused by mutation of the transthyretin protein ?
    • a. Familial Mediterranean fever
    • b. Familial amyloid polyneuropathy
    • c. Dialysis associated amyloidosis
    • d. Prion protein associated amyloidosis
  334. 334. In Familial Mediterranean fever, the gene encoding the following protein undergoes mulation :
    • a. Pyrin
    • b. Perforin
    • c. Atrial natriuretic factor
    • d. Immunoglobulin light chain
  335. 335. In apoptosis, Apaf-1 is activated by release of which of the following substances from the mitochondria?
    a. Bcl-2 b. Bax c. Bcl-XL d. Cytochrome c
  336. 336. All of the following CSf finding are present intuberculous meningitis (TBM), except:
    • a. Raised protein levels b. Low chloride levels
    • c. cobweb formation d. Raised sugar levels
  337. 337. Which of the following stains is specific for amyloid?
    • a. Periodic acid-Schiff(PAS) b. Alzerian red
    • c. Congo red d. Von kossa
  338. 338. Which one of the following disease characteristically causes fatty change in lever?
    • a. Hepatitis B virus infection b. Wilson’s disease
    • c. Hepatitis V virus infection d. Chronic alcoholism
  339. 339. A woman with infertility receives an ovary transplant from her sister who is an identical twin. What type of graft it is?
    • a. Xenograft b. autograft
    • c. Allograft d. Isograft
  340. 340. Type I hypersensitivity is mediated by which of the following immunoglobulins?
    a. IgA b. IgG c. IgM d. IgE
  341. 341. Aschoff nodules are seen in :
    • a. Subacute bacterial endocarditis
    • b. Libman- sacks endocarditis
    • c. Rheumatic carditis
    • d. Non- bacterial thrombotic endocarditis
Card Set
Pathology Sharad
sharad chandras pathology