Antidepressant Drugs - Tricyclics (TCA)

  1. Amitriptyline (Elavil, Endep)
    Doxepin (Sinequan, Adapin)
    Imipramine (Tofranil)
    Clomipramine (Anafranil) - particularly effective for Obsessive-Compulsive Disorder
  2. Uses:
    Most effective for depression inolving decreased appetite, weight loss, early morning awakening and other sleep disturbances, psychomotor retardation, anhedonia, and family history of depression with non-responsiveness to medication
  3. Uses:
    Successful in alleviating vegatative, somatic symptoms.

    Takes 2-4 weeks to have effect (use ECT for high risk, severe depression clients).

    Prescribed for severe phobic, hypochondriacal, and obsessiove states, Panic Disorder, chronic pain.
  4. Cardiotoxic Side Effects:
    • tachycardia
    • palpitations
    • hypertension
    • severe hypotention (drop in blood pressure)
    • cardiac arrhythmia

    • * Use with caution in people with heart disease
    • * Many side-effects common with elderly; alleviated by lower dose
    • * Overdose can be lethal (prescribe low quantities for high suicide risk)
  5. Anticholinergic Effects:
    • Dry Mouth
    • Blurred Vision
    • Urinary Retention
    • Constipation
    • Sexual Dysfunction
  6. Other Side Effects:
    • Confusion
    • Drowsiness
    • Fatigue
    • Blood Dyscrasia
    • Weight Gain
    • Tine Tremor
    • Paresthesia (subjective sensation experienced as numbness, tingling, or "pins and needles")
Card Set
Antidepressant Drugs - Tricyclics (TCA)
Drugs, Uses, and Side-Effects