Lecture#76 and #77

  1. what are the 5 cyotskeleton structures
    • intermediate filaments
    • microtubules
    • motor proteins
    • microfilaments
    • cell junctions
  2. what call of If for epitheial and appendaes
  3. what class of If for muscles
  4. what type if IF(intermideiate filament) for glial cells
  5. what type if IF(intermideiate filament) for mescenchyme
  6. what type if IF(intermideiate filament) for neurons and endothelial cells
    neurofilaments and nestin
  7. what type if IF(intermideiate filament) for nucleus cells
  8. what type if IF(intermideiate filament) for Lens and cataract cells
    Filensin and Phakinin
  9. IF characteristics
    • self assemble
    • create desmosomes and hemidesmosomes neuro filaments and laminin
  10. what structures are associated with intermediate filamements and what diseases
    • epidermylysis bullosa (EBS)
    • epidermilosis hyperkeratiin
    • muscuar dystropy 
    • hemidesmonsome
    • desmonsome
    • neurofilaments
  11. what structures are associated micro dtube and what diseases/diseae medications?
    • cilia, flagella, and Centrioles
    • colechine, periwinkle (Vinblastin), Taxol
  12. Motor protein name em
    • kinesins
    • dynein
    • myosin
  13. Kinesins
    • anterograde movement of stuff from center of cell to the peripherires 
    • two legs
  14. Dynein
    • retrograde of stuff fromt he peripheries to the center of the cell like mitochondria and golgi memebranes
    • pogo stick
  15. movement of cilia is based on
    presence of denin arms
  16. why are rotatry cili important in embryoeneisis
    fetermine left right axis/area based on how they beat
  17. which is faster dynein or kenesin
    dnein which isretrograde
  18. why are motor protein like dyenina dn kenisisn important to virology
    • virus can use motor protetin; hyjack to cary their own viral information
    • for example herpes virus can stay latent  using retrograde transport  then reactivate
  19. Microfilaments characteristics
    • made from gatin assemles to F-actin
    • polar
    • require ATP
    • non self assembly
  20. Wiskott Aldrich Syndrome
    there is an X recessive linked mutation int eh actin nucleating factor wasp
  21. what guides axon growth cone
    • frazzled  protein
    • robo 1
    • Comm
  22. what does robo do to growth cone
    repel growth cones from midline
  23. what does comm do to growth cone
    allow growth done to go through midline
  24. what does frazzled do to growth cone
    attract growth cone to midline
  25. Human disorderd of axon guidance
    • mirror synkinesis 
    • corpus callosum dysgenisis
    • horizontal gaze palsy
Card Set
Lecture#76 and #77
physiolgogy cyotoskeleton