Lecture #66 and #67

  1. ph
    -log of hydrogen ion concentration
  2. when it come to h20 for physiology assessment of aci and Base
    ignore h20 for simplicity
  3. pk definition
    pk is the ph when 50% dissociation of HA
  4. strong acid def.
    100% dissociation in soln
  5. if you have low pk the acid is
    stronger, more acidic
  6. buffer def.
    a weak acid in sln that resists changes in ph upon addition of H+ or base to system
  7. when o buffers work best?
    near the pk
  8. henderson hasselback
  9. how do you determine how many pka's an acid has?
    based on the forumula, how many hydrogens they have
  10. why is it important for the bodies pH to be held constant?
    15000-20,000 mMoles of volatile acid and 100-300 mM of non volitile acid
  11. what is a nonvolatile acid?
    • HCL, h2SO4 and H3PO4
    • they dissociate to produce free H+ions
    • produced by cellular metabolism of amino acid, nucleic acid, etc,
  12. what is a volitaile acid?
    • Co2
    • does not have hydrogen but in soln this can make carbonic acid which can then dissociate into H+
    • Co2 is a gas in that it can be exchanged with air and breathed off
  13. how does the body regulate CO2 Ha concentration
    by regulating the breathing
  14. how does the body regulate HCO3 (bicarbonate) Ha concentration?
    • through the kidney 
    • the kidney is the only organ that can eliminate H+ from the body
  15. What are  the Acid-Base Balance Disorder
    • Respiratory : change in the Pco2 in the plasma
    • Metabolic: change in HCO3 in the plasma
  16. what pco2 concentrations would be acidosis?
    greater than 40 mm Hg
  17. what pco2 concentrations would be alkalosis?
    less than 40 mm Hg
  18. what hco3 concentrations would be alkalosis?
    greater than 24mM
  19. what hco3 concentrations would be acidosis?
    less than 24 mM
  20. Phagocytosis
    • energy dependent 
    • vesicle>250 nm diameter
    • very big molceules
    • The size of the whole cell 
    • cell eating.
  21. what are some types of phagocyotic cells?
    • Dendrite
    • Neutrophils
    • Macrophages
  22. clinical relevance of phagocytotis
    • give defense against bacteria 
    • bacteria develops mchanisms to escaped degradation of lysosomes
  23. Clathrin coated
  24. Caveolin-coated vescile mediated edocytosis
    • Caveola-hav clustered signalling proteins
    • Dyamin 2-dependent pinching off
  25. where is caveolin 3 located
    skeletal muscles, smooth muscle, glial cells, erly post natal, peripheral nerves,
  26. LDL receptor recycling and disease - Brown and Goldstein Finding
    allows for binding and internalization of LDL
  27. what happen if your cells do not have LDl receptos
    there is very high cholesteralimia and cholesteral will build up so much it shows as bubbles on the skin
  28. exocytosis
    • vesicles 
    •  need a pari of SNARES to work
  29. transcyotsis
    • combination of endocytic and exocytic process
    • both fluid and solutes
  30. which cell sused transcytosis
    • endothelia, capillaries
    • intestinal epithelia
    • Lung 
    • thyroid
    • blod brain barrier
Card Set
Lecture #66 and #67
Physiology: Acid-Base Balance