in regards to reversibility is how do the nonaxidative and oxidative portions of PPP differ?
non-oxidative is reversible while ox is not.
hows does transketolase work and what does it need to function ?
move a ketone group around.
creates 3c and 5c molecules within this transfer
it need TPP thiamine pyrophosphate to funtion.
hows does transaldolase work and what does it need to function ?
transfer 3 carbon unit
what cause hemolytic anemia and G5PD deficiency ?
RBc generate alot oft ROs reactive oxygen species and this this can damge HB
usually the NADPH in the PPP reduce GSH ( glutathione and reduce the ROS thus repairing and preventing BY damage. When the PPP is down this causes an increase in the ROS and the RBC start to get lysed by the ROS
Heinz bodies form in RBC and RBC membrance becomes very fragile
an antioxidant produces by the PPP
what is significant about glucose 6 phosphate dehydrogenase ?
It is the first enzyme in both PPP and glycolysis
what population does the G6PD deficieny affect?
10% African american man
there is a G6PD mutation that correlated around the malarial belt